The HIV-1 Vpu viroporin inhibitor BIT225 does not affect Vpu-mediated tetherin antagonism.

Among its many roles, the HIV-1 accessory protein Vpu performs a viroporin function and also antagonizes the host cell restriction factor tetherin through its transmembrane domain. BIT225 is a small molecule inhibitor that specifically targets the Vpu viroporin function, which, in macrophages, resul...

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Autores principales: Björn D Kuhl, Vicky Cheng, Daniel A Donahue, Richard D Sloan, Chen Liang, John Wilkinson, Mark A Wainberg
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/41648ef9c33c4eeab16183c0fb71a58d
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