Nosocomial bloodstream infections in Brazilian pediatric patients: microbiology, epidemiology, and clinical features.

<h4>Background</h4>Nosocomial bloodstream infections (nBSIs) are an important cause of morbidity and mortality and are the most frequent type of nosocomial infection in pediatric patients.<h4>Methods</h4>We identified the predominant pathogens and antimicrobial susceptibiliti...

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Autores principales:	Carlos Alberto Pires Pereira, Alexandre R Marra, Luis Fernando Aranha Camargo, Antônio Carlos Campos Pignatari, Teresa Sukiennik, Paulo Renato Petersen Behar, Eduardo Alexandrino Servolo Medeiros, Julival Ribeiro, Evelyne Girão, Luci Correa, Carla Guerra, Irna Carneiro, Carlos Brites, Marise Reis, Marta Antunes de Souza, Regina Tranchesi, Cristina U Barata, Michael B Edmond, Brazilian SCOPE Study Group
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/41676af0b2d148a984097cba00c5fab7
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spelling	oai:doaj.org-article:41676af0b2d148a984097cba00c5fab72021-11-18T07:38:32ZNosocomial bloodstream infections in Brazilian pediatric patients: microbiology, epidemiology, and clinical features.1932-620310.1371/journal.pone.0068144https://doaj.org/article/41676af0b2d148a984097cba00c5fab72013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23861860/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Nosocomial bloodstream infections (nBSIs) are an important cause of morbidity and mortality and are the most frequent type of nosocomial infection in pediatric patients.<h4>Methods</h4>We identified the predominant pathogens and antimicrobial susceptibilities of nosocomial bloodstream isolates in pediatric patients (≤16 years of age) in the Brazilian Prospective Surveillance for nBSIs at 16 hospitals from 12 June 2007 to 31 March 2010 (Br SCOPE project).<h4>Results</h4>In our study a total of 2,563 cases of nBSI were reported by hospitals participating in the Br SCOPE project. Among these, 342 clinically significant episodes of BSI were identified in pediatric patients (≤16 years of age). Ninety-six percent of BSIs were monomicrobial. Gram-negative organisms caused 49.0% of these BSIs, Gram-positive organisms caused 42.6%, and fungi caused 8.4%. The most common pathogens were Coagulase-negative staphylococci (CoNS) (21.3%), Klebsiella spp. (15.7%), Staphylococcus aureus (10.6%), and Acinetobacter spp. (9.2%). The crude mortality was 21.6% (74 of 342). Forty-five percent of nBSIs occurred in a pediatric or neonatal intensive-care unit (ICU). The most frequent underlying conditions were malignancy, in 95 patients (27.8%). Among the potential factors predisposing patients to BSI, central venous catheters were the most frequent (66.4%). Methicillin resistance was detected in 37 S. aureus isolates (27.1%). Of the Klebsiella spp. isolates, 43.2% were resistant to ceftriaxone. Of the Acinetobacter spp. and Pseudomonas aeruginosa isolates, 42.9% and 21.4%, respectively, were resistant to imipenem.<h4>Conclusions</h4>In our multicenter study, we found a high mortality and a large proportion of gram-negative bacilli with elevated levels of resistance in pediatric patients.Carlos Alberto Pires PereiraAlexandre R MarraLuis Fernando Aranha CamargoAntônio Carlos Campos PignatariTeresa SukiennikPaulo Renato Petersen BeharEduardo Alexandrino Servolo MedeirosJulival RibeiroEvelyne GirãoLuci CorreaCarla GuerraIrna CarneiroCarlos BritesMarise ReisMarta Antunes de SouzaRegina TranchesiCristina U BarataMichael B EdmondBrazilian SCOPE Study GroupPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e68144 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carlos Alberto Pires Pereira Alexandre R Marra Luis Fernando Aranha Camargo Antônio Carlos Campos Pignatari Teresa Sukiennik Paulo Renato Petersen Behar Eduardo Alexandrino Servolo Medeiros Julival Ribeiro Evelyne Girão Luci Correa Carla Guerra Irna Carneiro Carlos Brites Marise Reis Marta Antunes de Souza Regina Tranchesi Cristina U Barata Michael B Edmond Brazilian SCOPE Study Group Nosocomial bloodstream infections in Brazilian pediatric patients: microbiology, epidemiology, and clinical features.
description	<h4>Background</h4>Nosocomial bloodstream infections (nBSIs) are an important cause of morbidity and mortality and are the most frequent type of nosocomial infection in pediatric patients.<h4>Methods</h4>We identified the predominant pathogens and antimicrobial susceptibilities of nosocomial bloodstream isolates in pediatric patients (≤16 years of age) in the Brazilian Prospective Surveillance for nBSIs at 16 hospitals from 12 June 2007 to 31 March 2010 (Br SCOPE project).<h4>Results</h4>In our study a total of 2,563 cases of nBSI were reported by hospitals participating in the Br SCOPE project. Among these, 342 clinically significant episodes of BSI were identified in pediatric patients (≤16 years of age). Ninety-six percent of BSIs were monomicrobial. Gram-negative organisms caused 49.0% of these BSIs, Gram-positive organisms caused 42.6%, and fungi caused 8.4%. The most common pathogens were Coagulase-negative staphylococci (CoNS) (21.3%), Klebsiella spp. (15.7%), Staphylococcus aureus (10.6%), and Acinetobacter spp. (9.2%). The crude mortality was 21.6% (74 of 342). Forty-five percent of nBSIs occurred in a pediatric or neonatal intensive-care unit (ICU). The most frequent underlying conditions were malignancy, in 95 patients (27.8%). Among the potential factors predisposing patients to BSI, central venous catheters were the most frequent (66.4%). Methicillin resistance was detected in 37 S. aureus isolates (27.1%). Of the Klebsiella spp. isolates, 43.2% were resistant to ceftriaxone. Of the Acinetobacter spp. and Pseudomonas aeruginosa isolates, 42.9% and 21.4%, respectively, were resistant to imipenem.<h4>Conclusions</h4>In our multicenter study, we found a high mortality and a large proportion of gram-negative bacilli with elevated levels of resistance in pediatric patients.
format	article
author	Carlos Alberto Pires Pereira Alexandre R Marra Luis Fernando Aranha Camargo Antônio Carlos Campos Pignatari Teresa Sukiennik Paulo Renato Petersen Behar Eduardo Alexandrino Servolo Medeiros Julival Ribeiro Evelyne Girão Luci Correa Carla Guerra Irna Carneiro Carlos Brites Marise Reis Marta Antunes de Souza Regina Tranchesi Cristina U Barata Michael B Edmond Brazilian SCOPE Study Group
author_facet	Carlos Alberto Pires Pereira Alexandre R Marra Luis Fernando Aranha Camargo Antônio Carlos Campos Pignatari Teresa Sukiennik Paulo Renato Petersen Behar Eduardo Alexandrino Servolo Medeiros Julival Ribeiro Evelyne Girão Luci Correa Carla Guerra Irna Carneiro Carlos Brites Marise Reis Marta Antunes de Souza Regina Tranchesi Cristina U Barata Michael B Edmond Brazilian SCOPE Study Group
author_sort	Carlos Alberto Pires Pereira
title	Nosocomial bloodstream infections in Brazilian pediatric patients: microbiology, epidemiology, and clinical features.
title_short	Nosocomial bloodstream infections in Brazilian pediatric patients: microbiology, epidemiology, and clinical features.
title_full	Nosocomial bloodstream infections in Brazilian pediatric patients: microbiology, epidemiology, and clinical features.
title_fullStr	Nosocomial bloodstream infections in Brazilian pediatric patients: microbiology, epidemiology, and clinical features.
title_full_unstemmed	Nosocomial bloodstream infections in Brazilian pediatric patients: microbiology, epidemiology, and clinical features.
title_sort	nosocomial bloodstream infections in brazilian pediatric patients: microbiology, epidemiology, and clinical features.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/41676af0b2d148a984097cba00c5fab7
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Nosocomial bloodstream infections in Brazilian pediatric patients: microbiology, epidemiology, and clinical features.

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