Efficacy and safety of using a fixed-dose combination of azilsartan medoxomil and chlorthalidone in patients with diabetes mellitus

All resent international and national guidelines for the treatment of patients with arterial hypertension offer a unified approach to the prescription of antihypertensive therapy. The vast majority of patients, including those with diabetes mellitus, require combined drugs. Renin-angiotensin-aldoste...

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Autores principales:	Juliya V. Zhernakova, Irina E. Chazova
Formato:	article
Lenguaje:	RU
Publicado:	IP Morozov P.V. 2021
Materias:	metabolic syndrome arterial hypertension combined drugs target organs Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/4175c06298d7460393727b5ac2732b25
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spelling	oai:doaj.org-article:4175c06298d7460393727b5ac2732b252021-11-30T16:09:16ZEfficacy and safety of using a fixed-dose combination of azilsartan medoxomil and chlorthalidone in patients with diabetes mellitus2075-082X2542-218910.26442/2075082X.2020.4.200556https://doaj.org/article/4175c06298d7460393727b5ac2732b252021-02-01T00:00:00Zhttps://syst-hypertension.ru/2075-082X/article/viewFile/60289/43460https://doaj.org/toc/2075-082Xhttps://doaj.org/toc/2542-2189All resent international and national guidelines for the treatment of patients with arterial hypertension offer a unified approach to the prescription of antihypertensive therapy. The vast majority of patients, including those with diabetes mellitus, require combined drugs. Renin-angiotensin-aldosterone system blockers, calcium channel blockers or diuretics are recommended as first-line therapy. The requirements for diuretics which can be used in this category of patients are especially strong. If patients with diabetes mellitus need diuretics as part of their antihypertensive therapy, thiazide-like diuretics should be preferred. Edarbi Clo, which is a fixed-dose combination of angiotensin receptor blocker azilsartan medoxomil and thiazide-like diuretic chlorthalidone met all these requirements. Along with its strong antihypertensive effect, Edarbi Clo has a beneficial effect on metabolism parameters, inflammation parameters and prevents damage to target organs, which makes it possible to recommend it as a drug of choice in this category of patients.Juliya V. ZhernakovaIrina E. ChazovaIP Morozov P.V.articlemetabolic syndromearterial hypertensioncombined drugstarget organsDiseases of the circulatory (Cardiovascular) systemRC666-701RUСистемные гипертензии, Vol 17, Iss 4, Pp 68-73 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	metabolic syndrome arterial hypertension combined drugs target organs Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	metabolic syndrome arterial hypertension combined drugs target organs Diseases of the circulatory (Cardiovascular) system RC666-701 Juliya V. Zhernakova Irina E. Chazova Efficacy and safety of using a fixed-dose combination of azilsartan medoxomil and chlorthalidone in patients with diabetes mellitus
description	All resent international and national guidelines for the treatment of patients with arterial hypertension offer a unified approach to the prescription of antihypertensive therapy. The vast majority of patients, including those with diabetes mellitus, require combined drugs. Renin-angiotensin-aldosterone system blockers, calcium channel blockers or diuretics are recommended as first-line therapy. The requirements for diuretics which can be used in this category of patients are especially strong. If patients with diabetes mellitus need diuretics as part of their antihypertensive therapy, thiazide-like diuretics should be preferred. Edarbi Clo, which is a fixed-dose combination of angiotensin receptor blocker azilsartan medoxomil and thiazide-like diuretic chlorthalidone met all these requirements. Along with its strong antihypertensive effect, Edarbi Clo has a beneficial effect on metabolism parameters, inflammation parameters and prevents damage to target organs, which makes it possible to recommend it as a drug of choice in this category of patients.
format	article
author	Juliya V. Zhernakova Irina E. Chazova
author_facet	Juliya V. Zhernakova Irina E. Chazova
author_sort	Juliya V. Zhernakova
title	Efficacy and safety of using a fixed-dose combination of azilsartan medoxomil and chlorthalidone in patients with diabetes mellitus
title_short	Efficacy and safety of using a fixed-dose combination of azilsartan medoxomil and chlorthalidone in patients with diabetes mellitus
title_full	Efficacy and safety of using a fixed-dose combination of azilsartan medoxomil and chlorthalidone in patients with diabetes mellitus
title_fullStr	Efficacy and safety of using a fixed-dose combination of azilsartan medoxomil and chlorthalidone in patients with diabetes mellitus
title_full_unstemmed	Efficacy and safety of using a fixed-dose combination of azilsartan medoxomil and chlorthalidone in patients with diabetes mellitus
title_sort	efficacy and safety of using a fixed-dose combination of azilsartan medoxomil and chlorthalidone in patients with diabetes mellitus
publisher	IP Morozov P.V.
publishDate	2021
url	https://doaj.org/article/4175c06298d7460393727b5ac2732b25
work_keys_str_mv	AT juliyavzhernakova efficacyandsafetyofusingafixeddosecombinationofazilsartanmedoxomilandchlorthalidoneinpatientswithdiabetesmellitus AT irinaechazova efficacyandsafetyofusingafixeddosecombinationofazilsartanmedoxomilandchlorthalidoneinpatientswithdiabetesmellitus
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Efficacy and safety of using a fixed-dose combination of azilsartan medoxomil and chlorthalidone in patients with diabetes mellitus

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