Microtubule minus-end aster organization is driven by processive HSET-tubulin clusters

Microtubules (MT) form higher-order structures such as asters, but the molecular pathway underlying aster formation remains unclear. Here authors demonstrate that the kinesin-14, HSET, clusters with soluble (nonMT) tubulin via its N-terminal tail domain and thereby promotes MT aster formation.

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Autores principales:	Stephen R. Norris, Seungyeon Jung, Prashant Singh, Claire E. Strothman, Amanda L. Erwin, Melanie D. Ohi, Marija Zanic, Ryoma Ohi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/417c0f27487b4b12b0815280d321f6b5
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spelling	oai:doaj.org-article:417c0f27487b4b12b0815280d321f6b52021-12-02T16:49:18ZMicrotubule minus-end aster organization is driven by processive HSET-tubulin clusters10.1038/s41467-018-04991-22041-1723https://doaj.org/article/417c0f27487b4b12b0815280d321f6b52018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04991-2https://doaj.org/toc/2041-1723Microtubules (MT) form higher-order structures such as asters, but the molecular pathway underlying aster formation remains unclear. Here authors demonstrate that the kinesin-14, HSET, clusters with soluble (nonMT) tubulin via its N-terminal tail domain and thereby promotes MT aster formation.Stephen R. NorrisSeungyeon JungPrashant SinghClaire E. StrothmanAmanda L. ErwinMelanie D. OhiMarija ZanicRyoma OhiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephen R. Norris Seungyeon Jung Prashant Singh Claire E. Strothman Amanda L. Erwin Melanie D. Ohi Marija Zanic Ryoma Ohi Microtubule minus-end aster organization is driven by processive HSET-tubulin clusters
description	Microtubules (MT) form higher-order structures such as asters, but the molecular pathway underlying aster formation remains unclear. Here authors demonstrate that the kinesin-14, HSET, clusters with soluble (nonMT) tubulin via its N-terminal tail domain and thereby promotes MT aster formation.
format	article
author	Stephen R. Norris Seungyeon Jung Prashant Singh Claire E. Strothman Amanda L. Erwin Melanie D. Ohi Marija Zanic Ryoma Ohi
author_facet	Stephen R. Norris Seungyeon Jung Prashant Singh Claire E. Strothman Amanda L. Erwin Melanie D. Ohi Marija Zanic Ryoma Ohi
author_sort	Stephen R. Norris
title	Microtubule minus-end aster organization is driven by processive HSET-tubulin clusters
title_short	Microtubule minus-end aster organization is driven by processive HSET-tubulin clusters
title_full	Microtubule minus-end aster organization is driven by processive HSET-tubulin clusters
title_fullStr	Microtubule minus-end aster organization is driven by processive HSET-tubulin clusters
title_full_unstemmed	Microtubule minus-end aster organization is driven by processive HSET-tubulin clusters
title_sort	microtubule minus-end aster organization is driven by processive hset-tubulin clusters
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/417c0f27487b4b12b0815280d321f6b5
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Microtubule minus-end aster organization is driven by processive HSET-tubulin clusters

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