Microtubule minus-end aster organization is driven by processive HSET-tubulin clusters

Microtubule minus-end aster organization is driven by processive HSET-tubulin clusters

Microtubules (MT) form higher-order structures such as asters, but the molecular pathway underlying aster formation remains unclear. Here authors demonstrate that the kinesin-14, HSET, clusters with soluble (nonMT) tubulin via its N-terminal tail domain and thereby promotes MT aster formation.

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Autores principales: Stephen R. Norris, Seungyeon Jung, Prashant Singh, Claire E. Strothman, Amanda L. Erwin, Melanie D. Ohi, Marija Zanic, Ryoma Ohi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/417c0f27487b4b12b0815280d321f6b5
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