Vascular Resection in Perihilar Cholangiocarcinoma

Among the cholangiocarcinomas, the most common type is perihilar (phCC), accounting for approximately 60% of cases, after which are the distal and then intrahepatic forms. There is no staging system that allows for a comparison of all series and extraction of conclusions that increase the long-term...

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Autores principales:	Alejandro Serrablo, Leyre Serrablo, Ruslan Alikhanov, Luis Tejedor
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	perihilar cholangiocarcinoma vascular invasion in perihilar cholangiocarcinoma biliary carcinoma surgery in vascular involvement Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/4180456464c2451baaf7744a5ab8a493
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spelling	oai:doaj.org-article:4180456464c2451baaf7744a5ab8a4932021-11-11T15:26:51ZVascular Resection in Perihilar Cholangiocarcinoma10.3390/cancers132152782072-6694https://doaj.org/article/4180456464c2451baaf7744a5ab8a4932021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5278https://doaj.org/toc/2072-6694Among the cholangiocarcinomas, the most common type is perihilar (phCC), accounting for approximately 60% of cases, after which are the distal and then intrahepatic forms. There is no staging system that allows for a comparison of all series and extraction of conclusions that increase the long-term survival rate of this dismal disease. The extension of the resection, which theoretically depends on the type of phCC, is not a closed subject. As surgery is the only known way to achieve a cure, many aggressive approaches have been adopted. Despite extended liver resections and even vascular resections, margins are positive in around one third of patients. In the past two decades, with advances in diagnostic and surgical techniques, surgical outcomes and survival rates have gradually improved, although variability is the rule, with morbidity and mortality rates ranging from 14% to 76% and from 0% to 19%, respectively. Extended hepatectomies and portal vein resection, or even right hepatic artery reconstruction for the left side tumors are frequently needed. Salvage procedures when arterial reconstruction is not feasible, as well as hepatopancreatoduodenectomy, are still under evaluation too. In this article, we discuss the aggressive surgical approach to phCC focused on vascular resection. Disparate results on the surgical treatment of phCC made it impossible to reach clear-cut conclusions.Alejandro SerrabloLeyre SerrabloRuslan AlikhanovLuis TejedorMDPI AGarticleperihilar cholangiocarcinomavascular invasion in perihilar cholangiocarcinomabiliary carcinomasurgery in vascular involvementNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5278, p 5278 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	perihilar cholangiocarcinoma vascular invasion in perihilar cholangiocarcinoma biliary carcinoma surgery in vascular involvement Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	perihilar cholangiocarcinoma vascular invasion in perihilar cholangiocarcinoma biliary carcinoma surgery in vascular involvement Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Alejandro Serrablo Leyre Serrablo Ruslan Alikhanov Luis Tejedor Vascular Resection in Perihilar Cholangiocarcinoma
description	Among the cholangiocarcinomas, the most common type is perihilar (phCC), accounting for approximately 60% of cases, after which are the distal and then intrahepatic forms. There is no staging system that allows for a comparison of all series and extraction of conclusions that increase the long-term survival rate of this dismal disease. The extension of the resection, which theoretically depends on the type of phCC, is not a closed subject. As surgery is the only known way to achieve a cure, many aggressive approaches have been adopted. Despite extended liver resections and even vascular resections, margins are positive in around one third of patients. In the past two decades, with advances in diagnostic and surgical techniques, surgical outcomes and survival rates have gradually improved, although variability is the rule, with morbidity and mortality rates ranging from 14% to 76% and from 0% to 19%, respectively. Extended hepatectomies and portal vein resection, or even right hepatic artery reconstruction for the left side tumors are frequently needed. Salvage procedures when arterial reconstruction is not feasible, as well as hepatopancreatoduodenectomy, are still under evaluation too. In this article, we discuss the aggressive surgical approach to phCC focused on vascular resection. Disparate results on the surgical treatment of phCC made it impossible to reach clear-cut conclusions.
format	article
author	Alejandro Serrablo Leyre Serrablo Ruslan Alikhanov Luis Tejedor
author_facet	Alejandro Serrablo Leyre Serrablo Ruslan Alikhanov Luis Tejedor
author_sort	Alejandro Serrablo
title	Vascular Resection in Perihilar Cholangiocarcinoma
title_short	Vascular Resection in Perihilar Cholangiocarcinoma
title_full	Vascular Resection in Perihilar Cholangiocarcinoma
title_fullStr	Vascular Resection in Perihilar Cholangiocarcinoma
title_full_unstemmed	Vascular Resection in Perihilar Cholangiocarcinoma
title_sort	vascular resection in perihilar cholangiocarcinoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/4180456464c2451baaf7744a5ab8a493
work_keys_str_mv	AT alejandroserrablo vascularresectioninperihilarcholangiocarcinoma AT leyreserrablo vascularresectioninperihilarcholangiocarcinoma AT ruslanalikhanov vascularresectioninperihilarcholangiocarcinoma AT luistejedor vascularresectioninperihilarcholangiocarcinoma
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Vascular Resection in Perihilar Cholangiocarcinoma

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