Retinal Microvasculature Changes After Repair of Macula-off Retinal Detachment Assessed with Optical Coherence Tomography Angiography

Retinal Microvasculature Changes After Repair of Macula-off Retinal Detachment Assessed with Optical Coherence Tomography Angiography

K Matthew McKay,1,* Filippos Vingopoulos,1,* Jay C Wang,1 Thanos D Papakostas,1,2 Rebecca F Silverman,1 Anna Marmalidou,1 Inês Lains,1 Dean Eliott,1 Demetrios G Vavvas,1 Leo A Kim,1 David M Wu,1 John B Miller1 1Retina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard...

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Autores principales: McKay KM, Vingopoulos F, Wang JC, Papakostas TD, Silverman RF, Marmalidou A, Lains I, Eliott D, Vavvas DG, Kim LA, Wu DM, Miller JB
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2020
Materias:
microvascular changes
oct-angiography
macula-off retinal detachment
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/4181241af06a444b97100dbc1379e6c3
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spelling oai:doaj.org-article:4181241af06a444b97100dbc1379e6c32021-12-02T11:53:52ZRetinal Microvasculature Changes After Repair of Macula-off Retinal Detachment Assessed with Optical Coherence Tomography Angiography1177-5483https://doaj.org/article/4181241af06a444b97100dbc1379e6c32020-06-01T00:00:00Zhttps://www.dovepress.com/retinal-microvasculature-changes-after-repair-of-macula-off-retinal-de-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483K Matthew McKay,1,* Filippos Vingopoulos,1,* Jay C Wang,1 Thanos D Papakostas,1,2 Rebecca F Silverman,1 Anna Marmalidou,1 Inês Lains,1 Dean Eliott,1 Demetrios G Vavvas,1 Leo A Kim,1 David M Wu,1 John B Miller1 1Retina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; 2Retina Service, Weill Cornell Medical College, New York, NY, USA*These authors contributed equally to this workCorrespondence: John B MillerRetina Service, Massachusetts Eye and Ear, Harvard Medical School, 243 Charles St, Boston, MA 02114 Tel +1 (617) 573-3750Fax +1 (617) 573-3698Email john_miller@meei.harvard.eduObjective: To characterize the microvascular retinal changes after repair of macula-off rhegmatogenous retinal detachment (RRD) using optical coherence tomography angiography (OCT-A).Patients and Methods: A retrospective review of patients who underwent repair of macula-off RRD. Fellow unaffected eyes were used as controls. Post-operative OCT-A allowed comparison of vessel density (VD) and foveal avascular zone (FAZ) area in the superficial and deep retinal capillary plexus (DCP) as well as VD in the choriocapillaris layer.Results: Seventeen eyes of 17 RRD patients were included in the final analysis. There was a reduction in VD of the deep retinal capillary plexus in affected eyes compared to fellow eyes (p = 0.046). RRD eyes with reduced VD in DCP compared with their fellow control eyes had worse visual acuity after repair compared to those without (p = 0.032). No significant microvasculature changes were detected in the FAZ area and VD in the superficial capillary plexus and choriocapillaris compared to fellow eyes.Conclusion: In macula-off RRD eyes, significant microvascular changes were detected in the DCP using OCT-A even after successful anatomical repair. Decreased VD in the DCP compared to the fellow healthy eyes was correlated with worse visual acuity.Keywords: microvascular changes, OCT-angiography, macula-off retinal detachmentMcKay KMVingopoulos FWang JCPapakostas TDSilverman RFMarmalidou ALains IEliott DVavvas DGKim LAWu DMMiller JBDove Medical Pressarticlemicrovascular changesoct-angiographymacula-off retinal detachmentOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 1759-1767 (2020)
institution DOAJ
collection DOAJ
language EN
topic microvascular changes
oct-angiography
macula-off retinal detachment
Ophthalmology
RE1-994
spellingShingle microvascular changes
oct-angiography
macula-off retinal detachment
Ophthalmology
RE1-994
McKay KM
Vingopoulos F
Wang JC
Papakostas TD
Silverman RF
Marmalidou A
Lains I
Eliott D
Vavvas DG
Kim LA
Wu DM
Miller JB
Retinal Microvasculature Changes After Repair of Macula-off Retinal Detachment Assessed with Optical Coherence Tomography Angiography
description K Matthew McKay,1,* Filippos Vingopoulos,1,* Jay C Wang,1 Thanos D Papakostas,1,2 Rebecca F Silverman,1 Anna Marmalidou,1 Inês Lains,1 Dean Eliott,1 Demetrios G Vavvas,1 Leo A Kim,1 David M Wu,1 John B Miller1 1Retina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, MA, USA; 2Retina Service, Weill Cornell Medical College, New York, NY, USA*These authors contributed equally to this workCorrespondence: John B MillerRetina Service, Massachusetts Eye and Ear, Harvard Medical School, 243 Charles St, Boston, MA 02114 Tel +1 (617) 573-3750Fax +1 (617) 573-3698Email john_miller@meei.harvard.eduObjective: To characterize the microvascular retinal changes after repair of macula-off rhegmatogenous retinal detachment (RRD) using optical coherence tomography angiography (OCT-A).Patients and Methods: A retrospective review of patients who underwent repair of macula-off RRD. Fellow unaffected eyes were used as controls. Post-operative OCT-A allowed comparison of vessel density (VD) and foveal avascular zone (FAZ) area in the superficial and deep retinal capillary plexus (DCP) as well as VD in the choriocapillaris layer.Results: Seventeen eyes of 17 RRD patients were included in the final analysis. There was a reduction in VD of the deep retinal capillary plexus in affected eyes compared to fellow eyes (p = 0.046). RRD eyes with reduced VD in DCP compared with their fellow control eyes had worse visual acuity after repair compared to those without (p = 0.032). No significant microvasculature changes were detected in the FAZ area and VD in the superficial capillary plexus and choriocapillaris compared to fellow eyes.Conclusion: In macula-off RRD eyes, significant microvascular changes were detected in the DCP using OCT-A even after successful anatomical repair. Decreased VD in the DCP compared to the fellow healthy eyes was correlated with worse visual acuity.Keywords: microvascular changes, OCT-angiography, macula-off retinal detachment
format article
author McKay KM
Vingopoulos F
Wang JC
Papakostas TD
Silverman RF
Marmalidou A
Lains I
Eliott D
Vavvas DG
Kim LA
Wu DM
Miller JB
author_facet McKay KM
Vingopoulos F
Wang JC
Papakostas TD
Silverman RF
Marmalidou A
Lains I
Eliott D
Vavvas DG
Kim LA
Wu DM
Miller JB
author_sort McKay KM
title Retinal Microvasculature Changes After Repair of Macula-off Retinal Detachment Assessed with Optical Coherence Tomography Angiography
title_short Retinal Microvasculature Changes After Repair of Macula-off Retinal Detachment Assessed with Optical Coherence Tomography Angiography
title_full Retinal Microvasculature Changes After Repair of Macula-off Retinal Detachment Assessed with Optical Coherence Tomography Angiography
title_fullStr Retinal Microvasculature Changes After Repair of Macula-off Retinal Detachment Assessed with Optical Coherence Tomography Angiography
title_full_unstemmed Retinal Microvasculature Changes After Repair of Macula-off Retinal Detachment Assessed with Optical Coherence Tomography Angiography
title_sort retinal microvasculature changes after repair of macula-off retinal detachment assessed with optical coherence tomography angiography
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/4181241af06a444b97100dbc1379e6c3
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