Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex
Zhiyou Cai,1 Yingjun Zhou,1 Zhou Liu,2,3 Zunyu Ke,1 Bin Zhao2,3 1Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, 2Department of Neurology, The Affiliated Hospital of Guangdong Medical College, 3Institute of Neurology, Guangdong Medical College, Zhanji...
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Dove Medical Press
2015
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oai:doaj.org-article:418265268db54e5a9425b4f0607511c12021-12-02T05:12:30ZAutophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex1178-2021https://doaj.org/article/418265268db54e5a9425b4f0607511c12015-08-01T00:00:00Zhttp://www.dovepress.com/autophagy-dysfunction-upregulates-beta-amyloid-peptides-via-enhancing--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Zhiyou Cai,1 Yingjun Zhou,1 Zhou Liu,2,3 Zunyu Ke,1 Bin Zhao2,3 1Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, 2Department of Neurology, The Affiliated Hospital of Guangdong Medical College, 3Institute of Neurology, Guangdong Medical College, Zhanjiang, Guangdong Province, People’s Republic of China Abstract: Numerous studies have shown that autophagy failure plays a critical role in the pathogenesis of Alzheimer’s disease, including increased expression of beta-amyloid (Aβ) protein and the dysfunction of Aβ clearance. To further evaluate the role of autophagy in Alzheimer’s disease, the present study was implemented to investigate the effects of autophagy on α-secretase, β-secretase, or γ-secretase, and observe the effects of autophagy on autophagic clearance markers. These results showed that both autophagy inhibitor and inducer enhanced the activity of α-, β-, and γ-secretases, and Aβ production. Autophagy inhibitor may more activate γ-secretase and promote Aβ production and accumulation than its inducer. Both autophagy inhibitor and inducer had no influence on Aβ clearance. Hence, autophagy inhibitor may activate γ-secretase and promote Aβ production and accumulation, but has no influence on Aβ clearance. Keywords: Alzheimer’s disease, autophagy, beta-amyloid, secretasesCai ZZhou YLiu ZKe ZZhao BDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 2091-2099 (2015) |
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DOAJ |
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EN |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Cai Z Zhou Y Liu Z Ke Z Zhao B Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex |
| description |
Zhiyou Cai,1 Yingjun Zhou,1 Zhou Liu,2,3 Zunyu Ke,1 Bin Zhao2,3 1Department of Neurology, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, 2Department of Neurology, The Affiliated Hospital of Guangdong Medical College, 3Institute of Neurology, Guangdong Medical College, Zhanjiang, Guangdong Province, People’s Republic of China Abstract: Numerous studies have shown that autophagy failure plays a critical role in the pathogenesis of Alzheimer’s disease, including increased expression of beta-amyloid (Aβ) protein and the dysfunction of Aβ clearance. To further evaluate the role of autophagy in Alzheimer’s disease, the present study was implemented to investigate the effects of autophagy on α-secretase, β-secretase, or γ-secretase, and observe the effects of autophagy on autophagic clearance markers. These results showed that both autophagy inhibitor and inducer enhanced the activity of α-, β-, and γ-secretases, and Aβ production. Autophagy inhibitor may more activate γ-secretase and promote Aβ production and accumulation than its inducer. Both autophagy inhibitor and inducer had no influence on Aβ clearance. Hence, autophagy inhibitor may activate γ-secretase and promote Aβ production and accumulation, but has no influence on Aβ clearance. Keywords: Alzheimer’s disease, autophagy, beta-amyloid, secretases |
| format |
article |
| author |
Cai Z Zhou Y Liu Z Ke Z Zhao B |
| author_facet |
Cai Z Zhou Y Liu Z Ke Z Zhao B |
| author_sort |
Cai Z |
| title |
Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex |
| title_short |
Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex |
| title_full |
Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex |
| title_fullStr |
Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex |
| title_full_unstemmed |
Autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex |
| title_sort |
autophagy dysfunction upregulates beta-amyloid peptides via enhancing the activity of γ-secretase complex |
| publisher |
Dove Medical Press |
| publishDate |
2015 |
| url |
https://doaj.org/article/418265268db54e5a9425b4f0607511c1 |
| work_keys_str_mv |
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1718400526050131968 |