Lupus Vasculitis: An Overview

Lupus vasculitis (LV) is one of the secondary vasculitides occurring in the setting of systemic lupus erythematosus (SLE) in approximately 50% of patients. It is most commonly associated with small vessels, but medium-sized vessels can also be affected, whereas large vessel involvement is very rare....

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Autores principales:	Patrizia Leone, Marcella Prete, Eleonora Malerba, Antonella Bray, Nicola Susca, Giuseppe Ingravallo, Vito Racanelli
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	vasculitis systemic lupus erythematosus lupus vasculitis small vessel vasculitis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/418329f2555c4e43b055a98f49e7e00f
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spelling	oai:doaj.org-article:418329f2555c4e43b055a98f49e7e00f2021-11-25T16:49:46ZLupus Vasculitis: An Overview10.3390/biomedicines91116262227-9059https://doaj.org/article/418329f2555c4e43b055a98f49e7e00f2021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1626https://doaj.org/toc/2227-9059Lupus vasculitis (LV) is one of the secondary vasculitides occurring in the setting of systemic lupus erythematosus (SLE) in approximately 50% of patients. It is most commonly associated with small vessels, but medium-sized vessels can also be affected, whereas large vessel involvement is very rare. LV may involve different organ systems and present in a wide variety of clinical manifestations according to the size and site of the vessels involved. LV usually portends a poor prognosis, and a prompt diagnosis is fundamental for a good outcome. The spectrum of involvement ranges from a relatively mild disease affecting small vessels or a single organ to a multiorgan system disease with life-threatening manifestations, such as mesenteric vasculitis, pulmonary hemorrhage, or mononeuritis multiplex. Treatment depends upon the organs involved and the severity of the vasculitis process. In this review, we provide an overview of the different forms of LV, describing their clinical impact and focusing on the available treatment strategies.Patrizia LeoneMarcella PreteEleonora MalerbaAntonella BrayNicola SuscaGiuseppe IngravalloVito RacanelliMDPI AGarticlevasculitissystemic lupus erythematosuslupus vasculitissmall vessel vasculitisBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1626, p 1626 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vasculitis systemic lupus erythematosus lupus vasculitis small vessel vasculitis Biology (General) QH301-705.5
spellingShingle	vasculitis systemic lupus erythematosus lupus vasculitis small vessel vasculitis Biology (General) QH301-705.5 Patrizia Leone Marcella Prete Eleonora Malerba Antonella Bray Nicola Susca Giuseppe Ingravallo Vito Racanelli Lupus Vasculitis: An Overview
description	Lupus vasculitis (LV) is one of the secondary vasculitides occurring in the setting of systemic lupus erythematosus (SLE) in approximately 50% of patients. It is most commonly associated with small vessels, but medium-sized vessels can also be affected, whereas large vessel involvement is very rare. LV may involve different organ systems and present in a wide variety of clinical manifestations according to the size and site of the vessels involved. LV usually portends a poor prognosis, and a prompt diagnosis is fundamental for a good outcome. The spectrum of involvement ranges from a relatively mild disease affecting small vessels or a single organ to a multiorgan system disease with life-threatening manifestations, such as mesenteric vasculitis, pulmonary hemorrhage, or mononeuritis multiplex. Treatment depends upon the organs involved and the severity of the vasculitis process. In this review, we provide an overview of the different forms of LV, describing their clinical impact and focusing on the available treatment strategies.
format	article
author	Patrizia Leone Marcella Prete Eleonora Malerba Antonella Bray Nicola Susca Giuseppe Ingravallo Vito Racanelli
author_facet	Patrizia Leone Marcella Prete Eleonora Malerba Antonella Bray Nicola Susca Giuseppe Ingravallo Vito Racanelli
author_sort	Patrizia Leone
title	Lupus Vasculitis: An Overview
title_short	Lupus Vasculitis: An Overview
title_full	Lupus Vasculitis: An Overview
title_fullStr	Lupus Vasculitis: An Overview
title_full_unstemmed	Lupus Vasculitis: An Overview
title_sort	lupus vasculitis: an overview
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/418329f2555c4e43b055a98f49e7e00f
work_keys_str_mv	AT patrizialeone lupusvasculitisanoverview AT marcellaprete lupusvasculitisanoverview AT eleonoramalerba lupusvasculitisanoverview AT antonellabray lupusvasculitisanoverview AT nicolasusca lupusvasculitisanoverview AT giuseppeingravallo lupusvasculitisanoverview AT vitoracanelli lupusvasculitisanoverview
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Lupus Vasculitis: An Overview

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