Autocrine IGF2 programmes β-cell plasticity under conditions of increased metabolic demand
Abstract When exposed to nutrient excess and insulin resistance, pancreatic β-cells undergo adaptive changes in order to maintain glucose homeostasis. The role that growth control genes, highly expressed in early pancreas development, might exert in programming β-cell plasticity in later life is a p...
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Autores principales: | Ionel Sandovici, Constanze M. Hammerle, Sam Virtue, Yurena Vivas-Garcia, Adriana Izquierdo-Lahuerta, Susan E. Ozanne, Antonio Vidal-Puig, Gema Medina-Gómez, Miguel Constância |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/418fc450d39f40d4b1305155c0e3ac81 |
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