IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease

IL-12p35 is common to IL-35 and IL-12, which have opposing effects on inflammation. Here the authors show that the IL-12p35 subunit induces regulatory B cells and can be used therapeutically to limit autoimmune uveitis in mice.

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Autores principales:	Ivy M. Dambuza, Chang He, Jin Kyeong Choi, Cheng-Rong Yu, Renxi Wang, Mary J. Mattapallil, Paul T. Wingfield, Rachel R. Caspi, Charles E. Egwuagu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4190c1c5e27f46209b8205b45199c5fa
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spelling	oai:doaj.org-article:4190c1c5e27f46209b8205b45199c5fa2021-12-02T14:40:46ZIL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease10.1038/s41467-017-00838-42041-1723https://doaj.org/article/4190c1c5e27f46209b8205b45199c5fa2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00838-4https://doaj.org/toc/2041-1723IL-12p35 is common to IL-35 and IL-12, which have opposing effects on inflammation. Here the authors show that the IL-12p35 subunit induces regulatory B cells and can be used therapeutically to limit autoimmune uveitis in mice.Ivy M. DambuzaChang HeJin Kyeong ChoiCheng-Rong YuRenxi WangMary J. MattapallilPaul T. WingfieldRachel R. CaspiCharles E. EgwuaguNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ivy M. Dambuza Chang He Jin Kyeong Choi Cheng-Rong Yu Renxi Wang Mary J. Mattapallil Paul T. Wingfield Rachel R. Caspi Charles E. Egwuagu IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease
description	IL-12p35 is common to IL-35 and IL-12, which have opposing effects on inflammation. Here the authors show that the IL-12p35 subunit induces regulatory B cells and can be used therapeutically to limit autoimmune uveitis in mice.
format	article
author	Ivy M. Dambuza Chang He Jin Kyeong Choi Cheng-Rong Yu Renxi Wang Mary J. Mattapallil Paul T. Wingfield Rachel R. Caspi Charles E. Egwuagu
author_facet	Ivy M. Dambuza Chang He Jin Kyeong Choi Cheng-Rong Yu Renxi Wang Mary J. Mattapallil Paul T. Wingfield Rachel R. Caspi Charles E. Egwuagu
author_sort	Ivy M. Dambuza
title	IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease
title_short	IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease
title_full	IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease
title_fullStr	IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease
title_full_unstemmed	IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease
title_sort	il-12p35 induces expansion of il-10 and il-35-expressing regulatory b cells and ameliorates autoimmune disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4190c1c5e27f46209b8205b45199c5fa
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IL-12p35 induces expansion of IL-10 and IL-35-expressing regulatory B cells and ameliorates autoimmune disease

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