PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells

Condensed abstract Paclitaxel-tolerant persister cancer cells (PCC) had PGRMC1 upregulation related to increased free fatty acids, lipid droplets, and fatty acid oxidation. PGRMC1 expression substantially increased ferroptosis by xCT inhibition via lipophagy and tubulin detyrosination, whereas PGRMC...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ji Hyeon You, Jaewang Lee, Jong-Lyel Roh
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Progesterone receptor membrane component 1 Ferroptosis Fatty acid oxidation Lipophagy Tubulin detyrosination Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/41933309701f4eca826b9aecb9d2a8b1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:41933309701f4eca826b9aecb9d2a8b1
record_format	dspace
spelling	oai:doaj.org-article:41933309701f4eca826b9aecb9d2a8b12021-11-14T12:15:22ZPGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells10.1186/s13046-021-02168-21756-9966https://doaj.org/article/41933309701f4eca826b9aecb9d2a8b12021-11-01T00:00:00Zhttps://doi.org/10.1186/s13046-021-02168-2https://doaj.org/toc/1756-9966Condensed abstract Paclitaxel-tolerant persister cancer cells (PCC) had PGRMC1 upregulation related to increased free fatty acids, lipid droplets, and fatty acid oxidation. PGRMC1 expression substantially increased ferroptosis by xCT inhibition via lipophagy and tubulin detyrosination, whereas PGRMC1 silencing decreased ferroptosis: this suggests that PGRMC1 expression promotes ferroptosis in PCC.Ji Hyeon YouJaewang LeeJong-Lyel RohBMCarticleProgesterone receptor membrane component 1FerroptosisFatty acid oxidationLipophagyTubulin detyrosinationNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENJournal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Progesterone receptor membrane component 1 Ferroptosis Fatty acid oxidation Lipophagy Tubulin detyrosination Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Progesterone receptor membrane component 1 Ferroptosis Fatty acid oxidation Lipophagy Tubulin detyrosination Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ji Hyeon You Jaewang Lee Jong-Lyel Roh PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells
description	Condensed abstract Paclitaxel-tolerant persister cancer cells (PCC) had PGRMC1 upregulation related to increased free fatty acids, lipid droplets, and fatty acid oxidation. PGRMC1 expression substantially increased ferroptosis by xCT inhibition via lipophagy and tubulin detyrosination, whereas PGRMC1 silencing decreased ferroptosis: this suggests that PGRMC1 expression promotes ferroptosis in PCC.
format	article
author	Ji Hyeon You Jaewang Lee Jong-Lyel Roh
author_facet	Ji Hyeon You Jaewang Lee Jong-Lyel Roh
author_sort	Ji Hyeon You
title	PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells
title_short	PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells
title_full	PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells
title_fullStr	PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells
title_full_unstemmed	PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells
title_sort	pgrmc1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells
publisher	BMC
publishDate	2021
url	https://doaj.org/article/41933309701f4eca826b9aecb9d2a8b1
work_keys_str_mv	AT jihyeonyou pgrmc1dependentlipophagypromotesferroptosisinpaclitaxeltolerantpersistercancercells AT jaewanglee pgrmc1dependentlipophagypromotesferroptosisinpaclitaxeltolerantpersistercancercells AT jonglyelroh pgrmc1dependentlipophagypromotesferroptosisinpaclitaxeltolerantpersistercancercells
_version_	1718429341750132736

PGRMC1-dependent lipophagy promotes ferroptosis in paclitaxel-tolerant persister cancer cells

Ejemplares similares