A processive phosphorylation circuit with multiple kinase inputs and mutually diversional routes controls G1/S decision
The decision of whether and when a cell divides is tightly controlled. Here, the authors show in yeast that there is a multi-step competition between different phosphorylation states and sites in the S phase CDK-Sic1 complex, which controls Sic1 degradation and coordinates the precise timing of the...
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Nature Portfolio
2020
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oai:doaj.org-article:4193f9a7643148afba8fdec5cd3947032021-12-02T17:31:39ZA processive phosphorylation circuit with multiple kinase inputs and mutually diversional routes controls G1/S decision10.1038/s41467-020-15685-z2041-1723https://doaj.org/article/4193f9a7643148afba8fdec5cd3947032020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15685-zhttps://doaj.org/toc/2041-1723The decision of whether and when a cell divides is tightly controlled. Here, the authors show in yeast that there is a multi-step competition between different phosphorylation states and sites in the S phase CDK-Sic1 complex, which controls Sic1 degradation and coordinates the precise timing of the G1/S transition.Rainis VentaErvin ValkMihkel ÖrdOleg KošikKaur PääboArtemi MaljavinRait KiviIlona FaustovaNastassia ShtaidaMartin LepikuKaidi MöllAndreas DoncicMardo KõivomägiMart LoogNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Rainis Venta Ervin Valk Mihkel Örd Oleg Košik Kaur Pääbo Artemi Maljavin Rait Kivi Ilona Faustova Nastassia Shtaida Martin Lepiku Kaidi Möll Andreas Doncic Mardo Kõivomägi Mart Loog A processive phosphorylation circuit with multiple kinase inputs and mutually diversional routes controls G1/S decision |
| description |
The decision of whether and when a cell divides is tightly controlled. Here, the authors show in yeast that there is a multi-step competition between different phosphorylation states and sites in the S phase CDK-Sic1 complex, which controls Sic1 degradation and coordinates the precise timing of the G1/S transition. |
| format |
article |
| author |
Rainis Venta Ervin Valk Mihkel Örd Oleg Košik Kaur Pääbo Artemi Maljavin Rait Kivi Ilona Faustova Nastassia Shtaida Martin Lepiku Kaidi Möll Andreas Doncic Mardo Kõivomägi Mart Loog |
| author_facet |
Rainis Venta Ervin Valk Mihkel Örd Oleg Košik Kaur Pääbo Artemi Maljavin Rait Kivi Ilona Faustova Nastassia Shtaida Martin Lepiku Kaidi Möll Andreas Doncic Mardo Kõivomägi Mart Loog |
| author_sort |
Rainis Venta |
| title |
A processive phosphorylation circuit with multiple kinase inputs and mutually diversional routes controls G1/S decision |
| title_short |
A processive phosphorylation circuit with multiple kinase inputs and mutually diversional routes controls G1/S decision |
| title_full |
A processive phosphorylation circuit with multiple kinase inputs and mutually diversional routes controls G1/S decision |
| title_fullStr |
A processive phosphorylation circuit with multiple kinase inputs and mutually diversional routes controls G1/S decision |
| title_full_unstemmed |
A processive phosphorylation circuit with multiple kinase inputs and mutually diversional routes controls G1/S decision |
| title_sort |
processive phosphorylation circuit with multiple kinase inputs and mutually diversional routes controls g1/s decision |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/4193f9a7643148afba8fdec5cd394703 |
| work_keys_str_mv |
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