Respiratory infections precede adult-onset asthma.

<h4>Background</h4>Respiratory infections in early life are associated with an increased risk of developing asthma but there is little evidence on the role of infections for onset of asthma in adults. The objective of this study was to assess the relation of the occurrence of respiratory...

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Autores principales:	Aino Rantala, Jouni J K Jaakkola, Maritta S Jaakkola
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/41945146650347dab627fa050eb909cb
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spelling	oai:doaj.org-article:41945146650347dab627fa050eb909cb2021-11-18T07:31:47ZRespiratory infections precede adult-onset asthma.1932-620310.1371/journal.pone.0027912https://doaj.org/article/41945146650347dab627fa050eb909cb2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22205932/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Respiratory infections in early life are associated with an increased risk of developing asthma but there is little evidence on the role of infections for onset of asthma in adults. The objective of this study was to assess the relation of the occurrence of respiratory infections in the past 12 months to adult-onset asthma in a population-based incident case-control study of adults 21-63 years of age.<h4>Methods/principal findings</h4>We recruited all new clinically diagnosed cases of asthma (n = 521) during a 2.5-year study period and randomly selected controls (n = 932) in a geographically defined area in South Finland. Information on respiratory infections was collected by a self-administered questionnaire. The diagnosis of asthma was based on symptoms and reversible airflow obstruction in lung function measurements. The risk of asthma onset was strongly increased in subjects who had experienced in the preceding 12 months lower respiratory tract infections (including acute bronchitis and pneumonia) with an adjusted odds ratio (OR) 7.18 (95% confidence interval [CI] 5.16-9.99), or upper respiratory tract infections (including common cold, sinusitis, tonsillitis, and otitis media) with an adjusted OR 2.26 (95% CI 1.72-2.97). Individuals with personal atopy and/or parental atopy were more susceptible to the effects of respiratory infections on asthma onset than non-atopic persons.<h4>Conclusions/significance</h4>This study provides new evidence that recently experienced respiratory infections are a strong determinant for adult-onset asthma. Reducing such infections might prevent onset of asthma in adulthood, especially in individuals with atopy or hereditary propensity to it.Aino RantalaJouni J K JaakkolaMaritta S JaakkolaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 12, p e27912 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aino Rantala Jouni J K Jaakkola Maritta S Jaakkola Respiratory infections precede adult-onset asthma.
description	<h4>Background</h4>Respiratory infections in early life are associated with an increased risk of developing asthma but there is little evidence on the role of infections for onset of asthma in adults. The objective of this study was to assess the relation of the occurrence of respiratory infections in the past 12 months to adult-onset asthma in a population-based incident case-control study of adults 21-63 years of age.<h4>Methods/principal findings</h4>We recruited all new clinically diagnosed cases of asthma (n = 521) during a 2.5-year study period and randomly selected controls (n = 932) in a geographically defined area in South Finland. Information on respiratory infections was collected by a self-administered questionnaire. The diagnosis of asthma was based on symptoms and reversible airflow obstruction in lung function measurements. The risk of asthma onset was strongly increased in subjects who had experienced in the preceding 12 months lower respiratory tract infections (including acute bronchitis and pneumonia) with an adjusted odds ratio (OR) 7.18 (95% confidence interval [CI] 5.16-9.99), or upper respiratory tract infections (including common cold, sinusitis, tonsillitis, and otitis media) with an adjusted OR 2.26 (95% CI 1.72-2.97). Individuals with personal atopy and/or parental atopy were more susceptible to the effects of respiratory infections on asthma onset than non-atopic persons.<h4>Conclusions/significance</h4>This study provides new evidence that recently experienced respiratory infections are a strong determinant for adult-onset asthma. Reducing such infections might prevent onset of asthma in adulthood, especially in individuals with atopy or hereditary propensity to it.
format	article
author	Aino Rantala Jouni J K Jaakkola Maritta S Jaakkola
author_facet	Aino Rantala Jouni J K Jaakkola Maritta S Jaakkola
author_sort	Aino Rantala
title	Respiratory infections precede adult-onset asthma.
title_short	Respiratory infections precede adult-onset asthma.
title_full	Respiratory infections precede adult-onset asthma.
title_fullStr	Respiratory infections precede adult-onset asthma.
title_full_unstemmed	Respiratory infections precede adult-onset asthma.
title_sort	respiratory infections precede adult-onset asthma.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/41945146650347dab627fa050eb909cb
work_keys_str_mv	AT ainorantala respiratoryinfectionsprecedeadultonsetasthma AT jounijkjaakkola respiratoryinfectionsprecedeadultonsetasthma AT marittasjaakkola respiratoryinfectionsprecedeadultonsetasthma
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Respiratory infections precede adult-onset asthma.

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