Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes

Bicyclo[1.1.1]pentanes (BCPs) are important motifs in contemporary drug design, however, approaches to BCPs featuring adjacent stereocenters are rather limited. Here, the authors report a photo- and organocatalyzed asymmetric addition of simple aldehydes to [1.1.1]propellane to generate enantioenric...

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Autores principales: Marie L. J. Wong, Alistair J. Sterling, James J. Mousseau, Fernanda Duarte, Edward A. Anderson
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/4195be37fc9045309b310a37ee8db78c
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spelling oai:doaj.org-article:4195be37fc9045309b310a37ee8db78c2021-12-02T11:36:15ZDirect catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes10.1038/s41467-021-21936-42041-1723https://doaj.org/article/4195be37fc9045309b310a37ee8db78c2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21936-4https://doaj.org/toc/2041-1723Bicyclo[1.1.1]pentanes (BCPs) are important motifs in contemporary drug design, however, approaches to BCPs featuring adjacent stereocenters are rather limited. Here, the authors report a photo- and organocatalyzed asymmetric addition of simple aldehydes to [1.1.1]propellane to generate enantioenriched α-chiral BCPs.Marie L. J. WongAlistair J. SterlingJames J. MousseauFernanda DuarteEdward A. AndersonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Marie L. J. Wong
Alistair J. Sterling
James J. Mousseau
Fernanda Duarte
Edward A. Anderson
Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes
description Bicyclo[1.1.1]pentanes (BCPs) are important motifs in contemporary drug design, however, approaches to BCPs featuring adjacent stereocenters are rather limited. Here, the authors report a photo- and organocatalyzed asymmetric addition of simple aldehydes to [1.1.1]propellane to generate enantioenriched α-chiral BCPs.
format article
author Marie L. J. Wong
Alistair J. Sterling
James J. Mousseau
Fernanda Duarte
Edward A. Anderson
author_facet Marie L. J. Wong
Alistair J. Sterling
James J. Mousseau
Fernanda Duarte
Edward A. Anderson
author_sort Marie L. J. Wong
title Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes
title_short Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes
title_full Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes
title_fullStr Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes
title_full_unstemmed Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes
title_sort direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/4195be37fc9045309b310a37ee8db78c
work_keys_str_mv AT marieljwong directcatalyticasymmetricsynthesisofachiralbicyclo111pentanes
AT alistairjsterling directcatalyticasymmetricsynthesisofachiralbicyclo111pentanes
AT jamesjmousseau directcatalyticasymmetricsynthesisofachiralbicyclo111pentanes
AT fernandaduarte directcatalyticasymmetricsynthesisofachiralbicyclo111pentanes
AT edwardaanderson directcatalyticasymmetricsynthesisofachiralbicyclo111pentanes
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