Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes
Bicyclo[1.1.1]pentanes (BCPs) are important motifs in contemporary drug design, however, approaches to BCPs featuring adjacent stereocenters are rather limited. Here, the authors report a photo- and organocatalyzed asymmetric addition of simple aldehydes to [1.1.1]propellane to generate enantioenric...
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Nature Portfolio
2021
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oai:doaj.org-article:4195be37fc9045309b310a37ee8db78c2021-12-02T11:36:15ZDirect catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes10.1038/s41467-021-21936-42041-1723https://doaj.org/article/4195be37fc9045309b310a37ee8db78c2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21936-4https://doaj.org/toc/2041-1723Bicyclo[1.1.1]pentanes (BCPs) are important motifs in contemporary drug design, however, approaches to BCPs featuring adjacent stereocenters are rather limited. Here, the authors report a photo- and organocatalyzed asymmetric addition of simple aldehydes to [1.1.1]propellane to generate enantioenriched α-chiral BCPs.Marie L. J. WongAlistair J. SterlingJames J. MousseauFernanda DuarteEdward A. AndersonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021) |
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Science Q Marie L. J. Wong Alistair J. Sterling James J. Mousseau Fernanda Duarte Edward A. Anderson Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes |
description |
Bicyclo[1.1.1]pentanes (BCPs) are important motifs in contemporary drug design, however, approaches to BCPs featuring adjacent stereocenters are rather limited. Here, the authors report a photo- and organocatalyzed asymmetric addition of simple aldehydes to [1.1.1]propellane to generate enantioenriched α-chiral BCPs. |
format |
article |
author |
Marie L. J. Wong Alistair J. Sterling James J. Mousseau Fernanda Duarte Edward A. Anderson |
author_facet |
Marie L. J. Wong Alistair J. Sterling James J. Mousseau Fernanda Duarte Edward A. Anderson |
author_sort |
Marie L. J. Wong |
title |
Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes |
title_short |
Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes |
title_full |
Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes |
title_fullStr |
Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes |
title_full_unstemmed |
Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes |
title_sort |
direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/4195be37fc9045309b310a37ee8db78c |
work_keys_str_mv |
AT marieljwong directcatalyticasymmetricsynthesisofachiralbicyclo111pentanes AT alistairjsterling directcatalyticasymmetricsynthesisofachiralbicyclo111pentanes AT jamesjmousseau directcatalyticasymmetricsynthesisofachiralbicyclo111pentanes AT fernandaduarte directcatalyticasymmetricsynthesisofachiralbicyclo111pentanes AT edwardaanderson directcatalyticasymmetricsynthesisofachiralbicyclo111pentanes |
_version_ |
1718395753866461184 |