Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes

Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes

Bicyclo[1.1.1]pentanes (BCPs) are important motifs in contemporary drug design, however, approaches to BCPs featuring adjacent stereocenters are rather limited. Here, the authors report a photo- and organocatalyzed asymmetric addition of simple aldehydes to [1.1.1]propellane to generate enantioenric...

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Autores principales: Marie L. J. Wong, Alistair J. Sterling, James J. Mousseau, Fernanda Duarte, Edward A. Anderson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/4195be37fc9045309b310a37ee8db78c
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