Are frontal cognitive and atrophy patterns different in PSP and bvFTD? A comparative neuropsychological and VBM study.

Progressive supranuclear palsy (PSP) and frontotemporal lobar degeneration (FTD) are two clinicohistological entities that share a severe prefrontal syndrome. To what extent do the cognitive syndrome and the location of the underlying brain atrophy unify or segregate these entities? Here, we examine...

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Autores principales:	Julien Lagarde, Romain Valabrègue, Jean-Christophe Corvol, Fanny Pineau, Isabelle Le Ber, Marie Vidailhet, Bruno Dubois, Richard Levy
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/41974ac391f04ff29f5805581911a162
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spelling	oai:doaj.org-article:41974ac391f04ff29f5805581911a1622021-11-18T08:45:28ZAre frontal cognitive and atrophy patterns different in PSP and bvFTD? A comparative neuropsychological and VBM study.1932-620310.1371/journal.pone.0080353https://doaj.org/article/41974ac391f04ff29f5805581911a1622013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24278277/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Progressive supranuclear palsy (PSP) and frontotemporal lobar degeneration (FTD) are two clinicohistological entities that share a severe prefrontal syndrome. To what extent do the cognitive syndrome and the location of the underlying brain atrophy unify or segregate these entities? Here, we examined the clinical and radiological patterns of frontal involvement and the neural bases of the cognitive dysfunctions observed in the Richardson form of PSP and the behavioral variant of FTD (bvFTD). The cognitive profile and grey and white matter volume of PSP (n = 19) and bvFTD (n = 16) patients and control participants (n = 18) were compared using a standard battery of neuropsychological tests and voxel-based morphometry (VBM), respectively. Analyses of correlations between neuropsychological and morphometric data were additionally performed. The severity and qualitative pattern of cognitive dysfunction was globally similar between the two patient groups. Grey matter volume was decreased in widespread frontal areas and in the temporal uncus in bvFTD, while it was decreased in the frontal and temporal lobes as well as in the thalamus in PSP. We also found an unexpected involvement of the frontal rectal gyrus in PSP patients compared to controls. Correlation analyses yielded different results in the two groups, with no area showing significant correlations in PSP patients, while several frontal and some temporal areas did so in bvFTD patients. In spite of minor neuropsychological and morphological differences, this study shows that the patterns of cognitive dysfunction and atrophy are very similar in PSP and bvFTD. However, executive dysfunction in these diseases may stem from partially divergent cortical and subcortical neural circuits.Julien LagardeRomain ValabrègueJean-Christophe CorvolFanny PineauIsabelle Le BerMarie VidailhetBruno DuboisRichard LevyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e80353 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Julien Lagarde Romain Valabrègue Jean-Christophe Corvol Fanny Pineau Isabelle Le Ber Marie Vidailhet Bruno Dubois Richard Levy Are frontal cognitive and atrophy patterns different in PSP and bvFTD? A comparative neuropsychological and VBM study.
description	Progressive supranuclear palsy (PSP) and frontotemporal lobar degeneration (FTD) are two clinicohistological entities that share a severe prefrontal syndrome. To what extent do the cognitive syndrome and the location of the underlying brain atrophy unify or segregate these entities? Here, we examined the clinical and radiological patterns of frontal involvement and the neural bases of the cognitive dysfunctions observed in the Richardson form of PSP and the behavioral variant of FTD (bvFTD). The cognitive profile and grey and white matter volume of PSP (n = 19) and bvFTD (n = 16) patients and control participants (n = 18) were compared using a standard battery of neuropsychological tests and voxel-based morphometry (VBM), respectively. Analyses of correlations between neuropsychological and morphometric data were additionally performed. The severity and qualitative pattern of cognitive dysfunction was globally similar between the two patient groups. Grey matter volume was decreased in widespread frontal areas and in the temporal uncus in bvFTD, while it was decreased in the frontal and temporal lobes as well as in the thalamus in PSP. We also found an unexpected involvement of the frontal rectal gyrus in PSP patients compared to controls. Correlation analyses yielded different results in the two groups, with no area showing significant correlations in PSP patients, while several frontal and some temporal areas did so in bvFTD patients. In spite of minor neuropsychological and morphological differences, this study shows that the patterns of cognitive dysfunction and atrophy are very similar in PSP and bvFTD. However, executive dysfunction in these diseases may stem from partially divergent cortical and subcortical neural circuits.
format	article
author	Julien Lagarde Romain Valabrègue Jean-Christophe Corvol Fanny Pineau Isabelle Le Ber Marie Vidailhet Bruno Dubois Richard Levy
author_facet	Julien Lagarde Romain Valabrègue Jean-Christophe Corvol Fanny Pineau Isabelle Le Ber Marie Vidailhet Bruno Dubois Richard Levy
author_sort	Julien Lagarde
title	Are frontal cognitive and atrophy patterns different in PSP and bvFTD? A comparative neuropsychological and VBM study.
title_short	Are frontal cognitive and atrophy patterns different in PSP and bvFTD? A comparative neuropsychological and VBM study.
title_full	Are frontal cognitive and atrophy patterns different in PSP and bvFTD? A comparative neuropsychological and VBM study.
title_fullStr	Are frontal cognitive and atrophy patterns different in PSP and bvFTD? A comparative neuropsychological and VBM study.
title_full_unstemmed	Are frontal cognitive and atrophy patterns different in PSP and bvFTD? A comparative neuropsychological and VBM study.
title_sort	are frontal cognitive and atrophy patterns different in psp and bvftd? a comparative neuropsychological and vbm study.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/41974ac391f04ff29f5805581911a162
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Are frontal cognitive and atrophy patterns different in PSP and bvFTD? A comparative neuropsychological and VBM study.

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