Metabolic engineering of Escherichia coli for de novo biosynthesis of vitamin B12

Vitamin B12 is an essential nutrient with limited natural sources. Here the authors transfer 28 pathway synthesis genes from several bacteria including R. capsulatus to E. coli and, using metabolic engineering and optimised fermentation conditions, achieve high yields.

Guardado en:

Detalles Bibliográficos
Autores principales:	Huan Fang, Dong Li, Jie Kang, Pingtao Jiang, Jibin Sun, Dawei Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/41974b62655e445fba8edc4e6f45103f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:41974b62655e445fba8edc4e6f45103f
record_format	dspace
spelling	oai:doaj.org-article:41974b62655e445fba8edc4e6f45103f2021-12-02T15:34:21ZMetabolic engineering of Escherichia coli for de novo biosynthesis of vitamin B1210.1038/s41467-018-07412-62041-1723https://doaj.org/article/41974b62655e445fba8edc4e6f45103f2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07412-6https://doaj.org/toc/2041-1723Vitamin B12 is an essential nutrient with limited natural sources. Here the authors transfer 28 pathway synthesis genes from several bacteria including R. capsulatus to E. coli and, using metabolic engineering and optimised fermentation conditions, achieve high yields.Huan FangDong LiJie KangPingtao JiangJibin SunDawei ZhangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huan Fang Dong Li Jie Kang Pingtao Jiang Jibin Sun Dawei Zhang Metabolic engineering of Escherichia coli for de novo biosynthesis of vitamin B12
description	Vitamin B12 is an essential nutrient with limited natural sources. Here the authors transfer 28 pathway synthesis genes from several bacteria including R. capsulatus to E. coli and, using metabolic engineering and optimised fermentation conditions, achieve high yields.
format	article
author	Huan Fang Dong Li Jie Kang Pingtao Jiang Jibin Sun Dawei Zhang
author_facet	Huan Fang Dong Li Jie Kang Pingtao Jiang Jibin Sun Dawei Zhang
author_sort	Huan Fang
title	Metabolic engineering of Escherichia coli for de novo biosynthesis of vitamin B12
title_short	Metabolic engineering of Escherichia coli for de novo biosynthesis of vitamin B12
title_full	Metabolic engineering of Escherichia coli for de novo biosynthesis of vitamin B12
title_fullStr	Metabolic engineering of Escherichia coli for de novo biosynthesis of vitamin B12
title_full_unstemmed	Metabolic engineering of Escherichia coli for de novo biosynthesis of vitamin B12
title_sort	metabolic engineering of escherichia coli for de novo biosynthesis of vitamin b12
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/41974b62655e445fba8edc4e6f45103f
work_keys_str_mv	AT huanfang metabolicengineeringofescherichiacolifordenovobiosynthesisofvitaminb12 AT dongli metabolicengineeringofescherichiacolifordenovobiosynthesisofvitaminb12 AT jiekang metabolicengineeringofescherichiacolifordenovobiosynthesisofvitaminb12 AT pingtaojiang metabolicengineeringofescherichiacolifordenovobiosynthesisofvitaminb12 AT jibinsun metabolicengineeringofescherichiacolifordenovobiosynthesisofvitaminb12 AT daweizhang metabolicengineeringofescherichiacolifordenovobiosynthesisofvitaminb12
_version_	1718386834167300096

Metabolic engineering of Escherichia coli for de novo biosynthesis of vitamin B12

Ejemplares similares