Diabetes mellitus and risk of thyroid cancer: a meta-analysis.

<h4>Introduction</h4>Diabetes mellitus (DM) is an important risk factor for endocrine cancers; however, the association with thyroid cancer is not clear. We performed a systematic review and meta-analysis to clarify the association between thyroid cancer and DM.<h4>Methods</h4&g...

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Autores principales:	Yohwan Yeo, Seung-Hyun Ma, Yunji Hwang, Pamela L Horn-Ross, Ann Hsing, Kyu-Eun Lee, Young Joo Park, Do-Joon Park, Keun-Young Yoo, Sue K Park
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/419856bff1fa40e69b204548aba25de8
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spelling	oai:doaj.org-article:419856bff1fa40e69b204548aba25de82021-11-18T08:15:43ZDiabetes mellitus and risk of thyroid cancer: a meta-analysis.1932-620310.1371/journal.pone.0098135https://doaj.org/article/419856bff1fa40e69b204548aba25de82014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24927125/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>Diabetes mellitus (DM) is an important risk factor for endocrine cancers; however, the association with thyroid cancer is not clear. We performed a systematic review and meta-analysis to clarify the association between thyroid cancer and DM.<h4>Methods</h4>We searched MEDLINE, PUBMED and EMBASE databases through July 2012, using search terms related to diabetes mellitus, cancer, and thyroid cancer. We conducted a meta-analysis of the risk of incidence of thyroid cancer from pre-existing diabetes. Of 2,123 titles initially identified, sixteen articles met our inclusion criteria. An additional article was identified from a bibliography. Totally, 14 cohort and 3 case-control studies were selected for the meta-analysis. The risks were estimated using random-effects model and sensitivity test for the studies which reported risk estimates and used different definition of DM.<h4>Results</h4>Compared with individuals without DM, the patients with DM were at 1.34-fold higher risk for thyroid cancer (95% CI 1.11-1.63). However, there was heterogeneity in the results (p<0.0001). Sensitivity tests and studies judged to be high quality did not show heterogeneity and DM was associated with higher risk for thyroid cancer in these sub-analyses (both of RRs = 1.18, 95% CIs 1.08-1.28). DM was associated with a 1.38-fold increased risk of thyroid cancer in women (95% CI 1.13-1.67) after sensitivity test. Risk of thyroid cancer in men did not remain significant (RR 1.11, 95% CI 0.80-1.53).<h4>Conclusions</h4>Compared with their non-diabetic counterparts, women with pre-existing DM have an increased risk of thyroid cancer.Yohwan YeoSeung-Hyun MaYunji HwangPamela L Horn-RossAnn HsingKyu-Eun LeeYoung Joo ParkDo-Joon ParkKeun-Young YooSue K ParkPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e98135 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yohwan Yeo Seung-Hyun Ma Yunji Hwang Pamela L Horn-Ross Ann Hsing Kyu-Eun Lee Young Joo Park Do-Joon Park Keun-Young Yoo Sue K Park Diabetes mellitus and risk of thyroid cancer: a meta-analysis.
description	<h4>Introduction</h4>Diabetes mellitus (DM) is an important risk factor for endocrine cancers; however, the association with thyroid cancer is not clear. We performed a systematic review and meta-analysis to clarify the association between thyroid cancer and DM.<h4>Methods</h4>We searched MEDLINE, PUBMED and EMBASE databases through July 2012, using search terms related to diabetes mellitus, cancer, and thyroid cancer. We conducted a meta-analysis of the risk of incidence of thyroid cancer from pre-existing diabetes. Of 2,123 titles initially identified, sixteen articles met our inclusion criteria. An additional article was identified from a bibliography. Totally, 14 cohort and 3 case-control studies were selected for the meta-analysis. The risks were estimated using random-effects model and sensitivity test for the studies which reported risk estimates and used different definition of DM.<h4>Results</h4>Compared with individuals without DM, the patients with DM were at 1.34-fold higher risk for thyroid cancer (95% CI 1.11-1.63). However, there was heterogeneity in the results (p<0.0001). Sensitivity tests and studies judged to be high quality did not show heterogeneity and DM was associated with higher risk for thyroid cancer in these sub-analyses (both of RRs = 1.18, 95% CIs 1.08-1.28). DM was associated with a 1.38-fold increased risk of thyroid cancer in women (95% CI 1.13-1.67) after sensitivity test. Risk of thyroid cancer in men did not remain significant (RR 1.11, 95% CI 0.80-1.53).<h4>Conclusions</h4>Compared with their non-diabetic counterparts, women with pre-existing DM have an increased risk of thyroid cancer.
format	article
author	Yohwan Yeo Seung-Hyun Ma Yunji Hwang Pamela L Horn-Ross Ann Hsing Kyu-Eun Lee Young Joo Park Do-Joon Park Keun-Young Yoo Sue K Park
author_facet	Yohwan Yeo Seung-Hyun Ma Yunji Hwang Pamela L Horn-Ross Ann Hsing Kyu-Eun Lee Young Joo Park Do-Joon Park Keun-Young Yoo Sue K Park
author_sort	Yohwan Yeo
title	Diabetes mellitus and risk of thyroid cancer: a meta-analysis.
title_short	Diabetes mellitus and risk of thyroid cancer: a meta-analysis.
title_full	Diabetes mellitus and risk of thyroid cancer: a meta-analysis.
title_fullStr	Diabetes mellitus and risk of thyroid cancer: a meta-analysis.
title_full_unstemmed	Diabetes mellitus and risk of thyroid cancer: a meta-analysis.
title_sort	diabetes mellitus and risk of thyroid cancer: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/419856bff1fa40e69b204548aba25de8
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Diabetes mellitus and risk of thyroid cancer: a meta-analysis.

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