A computer-guided design tool to increase the efficiency of cellular conversions

A computer-guided design tool to increase the efficiency of cellular conversions

Transcription factor over-expression-based cellular conversion methods often endure low conversion efficiency. Here the authors show how to increase conversion efficiency by combining a computational method for prioritizing more efficient TF combinations with a transposon-based genomic integration s...

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Autores principales: Sascha Jung, Evan Appleton, Muhammad Ali, George M. Church, Antonio del Sol
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
Q
Acceso en línea:https://doaj.org/article/4198d7dbb42044ab9618224223c9a936
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spelling oai:doaj.org-article:4198d7dbb42044ab9618224223c9a9362021-12-02T13:30:36ZA computer-guided design tool to increase the efficiency of cellular conversions10.1038/s41467-021-21801-42041-1723https://doaj.org/article/4198d7dbb42044ab9618224223c9a9362021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21801-4https://doaj.org/toc/2041-1723Transcription factor over-expression-based cellular conversion methods often endure low conversion efficiency. Here the authors show how to increase conversion efficiency by combining a computational method for prioritizing more efficient TF combinations with a transposon-based genomic integration system for delivery.Sascha JungEvan AppletonMuhammad AliGeorge M. ChurchAntonio del SolNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sascha Jung
Evan Appleton
Muhammad Ali
George M. Church
Antonio del Sol
A computer-guided design tool to increase the efficiency of cellular conversions
description Transcription factor over-expression-based cellular conversion methods often endure low conversion efficiency. Here the authors show how to increase conversion efficiency by combining a computational method for prioritizing more efficient TF combinations with a transposon-based genomic integration system for delivery.
format article
author Sascha Jung
Evan Appleton
Muhammad Ali
George M. Church
Antonio del Sol
author_facet Sascha Jung
Evan Appleton
Muhammad Ali
George M. Church
Antonio del Sol
author_sort Sascha Jung
title A computer-guided design tool to increase the efficiency of cellular conversions
title_short A computer-guided design tool to increase the efficiency of cellular conversions
title_full A computer-guided design tool to increase the efficiency of cellular conversions
title_fullStr A computer-guided design tool to increase the efficiency of cellular conversions
title_full_unstemmed A computer-guided design tool to increase the efficiency of cellular conversions
title_sort computer-guided design tool to increase the efficiency of cellular conversions
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/4198d7dbb42044ab9618224223c9a936
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