A computer-guided design tool to increase the efficiency of cellular conversions

Transcription factor over-expression-based cellular conversion methods often endure low conversion efficiency. Here the authors show how to increase conversion efficiency by combining a computational method for prioritizing more efficient TF combinations with a transposon-based genomic integration s...

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Autores principales: Sascha Jung, Evan Appleton, Muhammad Ali, George M. Church, Antonio del Sol
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/4198d7dbb42044ab9618224223c9a936
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