Radiological Characteristics of Patients With Anti-MDA5–Antibody-Positive Dermatomyositis in 18F-FDG PET/CT: A Pilot Study

Objective: To elucidate the 18F-fluorodeoxyglucose (FDG) PET/CT characteristics and its prognostic value in the patients with anti-melanoma differentiation associated protein 5 antibody positive (anti-MDA5+) dermatomyositis (DM).Methods: This retrospective cross-sectional study included 26 patients...

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Autores principales:	Heng Cao, Junyu Liang, Danyi Xu, Yinuo Liu, Yinan Yao, Yiduo Sun, Ye He, Jin Lin
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	dermatomyositis melanoma differentiation associated protein 5 (MDA5) 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) interstitial lung disease (ILD) standardized uptake value (SUV) Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/41991900af164fc2b0bb6d1570c756a2
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spelling	oai:doaj.org-article:41991900af164fc2b0bb6d1570c756a22021-11-22T04:33:00ZRadiological Characteristics of Patients With Anti-MDA5–Antibody-Positive Dermatomyositis in 18F-FDG PET/CT: A Pilot Study2296-858X10.3389/fmed.2021.779272https://doaj.org/article/41991900af164fc2b0bb6d1570c756a22021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.779272/fullhttps://doaj.org/toc/2296-858XObjective: To elucidate the 18F-fluorodeoxyglucose (FDG) PET/CT characteristics and its prognostic value in the patients with anti-melanoma differentiation associated protein 5 antibody positive (anti-MDA5+) dermatomyositis (DM).Methods: This retrospective cross-sectional study included 26 patients with anti-MDA5+ DM and 43 patients with anti-MDA5 negative (anti-MDA5–) idiopathic inflammatory myopathy (IIM) who were examined by 18F-FDG PET/CT from January 1, 2017 to December 31, 2020. The maximum standardized uptake value (SUVmax) of multiple organs and other clinical characteristics of the patients were measured and analyzed.Results: Compared with the anti-MDA5– group, the patients in the anti-MDA5+ group showed higher bilateral lung SUVmax (p = 0.029), higher SUVmax of spleen (p = 0.011), and bone marrow (p = 0.048). Significant correlations between the spleen SUVmax and serum ferritin levels (r = 0.398, p < 0.001), erythrocyte sedimentation rate (ESR) (r = 0.274, p = 0.023), platelet count (r = −0.265, p= 0.028), myositis disease activity assessment score (r = 0.332, p = 0.005), bone marrow SUVmax (r = 0.564, p < 0.001), and bilateral lung SUVmax (r = 0.393, p < 0.001) were observed.Conclusion:18F-FDG PET/CT was found valuable in quantifying the pulmonary focal inflammation and potentially unveil the distinctive characteristics and pathophysiological mechanisms in the patients with anti-MDA5+ DM.Heng CaoJunyu LiangDanyi XuYinuo LiuYinan YaoYiduo SunYe HeJin LinFrontiers Media S.A.articledermatomyositismelanoma differentiation associated protein 5 (MDA5)18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)interstitial lung disease (ILD)standardized uptake value (SUV)Medicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dermatomyositis melanoma differentiation associated protein 5 (MDA5) 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) interstitial lung disease (ILD) standardized uptake value (SUV) Medicine (General) R5-920
spellingShingle	dermatomyositis melanoma differentiation associated protein 5 (MDA5) 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) interstitial lung disease (ILD) standardized uptake value (SUV) Medicine (General) R5-920 Heng Cao Junyu Liang Danyi Xu Yinuo Liu Yinan Yao Yiduo Sun Ye He Jin Lin Radiological Characteristics of Patients With Anti-MDA5–Antibody-Positive Dermatomyositis in 18F-FDG PET/CT: A Pilot Study
description	Objective: To elucidate the 18F-fluorodeoxyglucose (FDG) PET/CT characteristics and its prognostic value in the patients with anti-melanoma differentiation associated protein 5 antibody positive (anti-MDA5+) dermatomyositis (DM).Methods: This retrospective cross-sectional study included 26 patients with anti-MDA5+ DM and 43 patients with anti-MDA5 negative (anti-MDA5–) idiopathic inflammatory myopathy (IIM) who were examined by 18F-FDG PET/CT from January 1, 2017 to December 31, 2020. The maximum standardized uptake value (SUVmax) of multiple organs and other clinical characteristics of the patients were measured and analyzed.Results: Compared with the anti-MDA5– group, the patients in the anti-MDA5+ group showed higher bilateral lung SUVmax (p = 0.029), higher SUVmax of spleen (p = 0.011), and bone marrow (p = 0.048). Significant correlations between the spleen SUVmax and serum ferritin levels (r = 0.398, p < 0.001), erythrocyte sedimentation rate (ESR) (r = 0.274, p = 0.023), platelet count (r = −0.265, p= 0.028), myositis disease activity assessment score (r = 0.332, p = 0.005), bone marrow SUVmax (r = 0.564, p < 0.001), and bilateral lung SUVmax (r = 0.393, p < 0.001) were observed.Conclusion:18F-FDG PET/CT was found valuable in quantifying the pulmonary focal inflammation and potentially unveil the distinctive characteristics and pathophysiological mechanisms in the patients with anti-MDA5+ DM.
format	article
author	Heng Cao Junyu Liang Danyi Xu Yinuo Liu Yinan Yao Yiduo Sun Ye He Jin Lin
author_facet	Heng Cao Junyu Liang Danyi Xu Yinuo Liu Yinan Yao Yiduo Sun Ye He Jin Lin
author_sort	Heng Cao
title	Radiological Characteristics of Patients With Anti-MDA5–Antibody-Positive Dermatomyositis in 18F-FDG PET/CT: A Pilot Study
title_short	Radiological Characteristics of Patients With Anti-MDA5–Antibody-Positive Dermatomyositis in 18F-FDG PET/CT: A Pilot Study
title_full	Radiological Characteristics of Patients With Anti-MDA5–Antibody-Positive Dermatomyositis in 18F-FDG PET/CT: A Pilot Study
title_fullStr	Radiological Characteristics of Patients With Anti-MDA5–Antibody-Positive Dermatomyositis in 18F-FDG PET/CT: A Pilot Study
title_full_unstemmed	Radiological Characteristics of Patients With Anti-MDA5–Antibody-Positive Dermatomyositis in 18F-FDG PET/CT: A Pilot Study
title_sort	radiological characteristics of patients with anti-mda5–antibody-positive dermatomyositis in 18f-fdg pet/ct: a pilot study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/41991900af164fc2b0bb6d1570c756a2
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Radiological Characteristics of Patients With Anti-MDA5–Antibody-Positive Dermatomyositis in 18F-FDG PET/CT: A Pilot Study

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