FOXP3+T-REGULATORY LYMPHOCYTES AND AUTOANTIBODIES IN PATIENTS WITH ARTERIAL HYPERTENSION, ASSOCIATED WITH DIABETES MELLITUS TYPE 2 AND IMPAIRED GLUCOSE TOLERANCE

When studying patients with an association of arterial hypertension and type 2 diabetes mellitus, we have shown a lower number of FoxP3+T-regulatory cells, as well as elevated levels of anti-myocardial antibodies and autoantibodies to nuclear antigens. In a group with combination of impaired glucose...

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Autores principales:	I. V. Kologrivova, T. E. Suslova, O. A. Koshelskaya, I. V. Vinnizkaya, O. A. Trubacheva, N. M. Zheltonogova, A. M. Gusakova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	autoantibodies foxp3+t-regulatory lymphocytes diabetes mellitus type 2 impaired glucose tolerance Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/419c1910c30e4a81b8c61f3c48141fef
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spelling	oai:doaj.org-article:419c1910c30e4a81b8c61f3c48141fef2021-11-18T08:03:38ZFOXP3+T-REGULATORY LYMPHOCYTES AND AUTOANTIBODIES IN PATIENTS WITH ARTERIAL HYPERTENSION, ASSOCIATED WITH DIABETES MELLITUS TYPE 2 AND IMPAIRED GLUCOSE TOLERANCE1563-06252313-741X10.15789/1563-0625-2013-2-155-162https://doaj.org/article/419c1910c30e4a81b8c61f3c48141fef2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/106https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XWhen studying patients with an association of arterial hypertension and type 2 diabetes mellitus, we have shown a lower number of FoxP3+T-regulatory cells, as well as elevated levels of anti-myocardial antibodies and autoantibodies to nuclear antigens. In a group with combination of impaired glucose tolerance and arterial hypertension, a decrease in T-regulatory lymphocytes’ numbers, along with increased rheumatoid factor and antimitochondrial autoantibodies concentrations were observed. Arterial hypertension was combined with dyslipidemia, being accompanied by higher levels of rheumatoid factor and antibodies to nuclear antigens. In all these clinical groups, we revealed close correlations between concentrations of autoantibodies, FoxP3+T-regulatory lymphocyte scores, and parameters of carbohydrate and lipid metabolism. The results, obtained in present study, allow us to suggest that metabolic disturbances may be associated with altered immune tolerance mechanisms and activation of humoral immune response that are detectable since early stages of the disease and may contribute to development of complications occurring in diabetes mellitus type 2.I. V. KologrivovaT. E. SuslovaO. A. KoshelskayaI. V. VinnizkayaO. A. TrubachevaN. M. ZheltonogovaA. M. GusakovaSPb RAACIarticleautoantibodiesfoxp3+t-regulatory lymphocytesdiabetes mellitus type 2impaired glucose toleranceImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 2, Pp 155-162 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	autoantibodies foxp3+t-regulatory lymphocytes diabetes mellitus type 2 impaired glucose tolerance Immunologic diseases. Allergy RC581-607
spellingShingle	autoantibodies foxp3+t-regulatory lymphocytes diabetes mellitus type 2 impaired glucose tolerance Immunologic diseases. Allergy RC581-607 I. V. Kologrivova T. E. Suslova O. A. Koshelskaya I. V. Vinnizkaya O. A. Trubacheva N. M. Zheltonogova A. M. Gusakova FOXP3+T-REGULATORY LYMPHOCYTES AND AUTOANTIBODIES IN PATIENTS WITH ARTERIAL HYPERTENSION, ASSOCIATED WITH DIABETES MELLITUS TYPE 2 AND IMPAIRED GLUCOSE TOLERANCE
description	When studying patients with an association of arterial hypertension and type 2 diabetes mellitus, we have shown a lower number of FoxP3+T-regulatory cells, as well as elevated levels of anti-myocardial antibodies and autoantibodies to nuclear antigens. In a group with combination of impaired glucose tolerance and arterial hypertension, a decrease in T-regulatory lymphocytes’ numbers, along with increased rheumatoid factor and antimitochondrial autoantibodies concentrations were observed. Arterial hypertension was combined with dyslipidemia, being accompanied by higher levels of rheumatoid factor and antibodies to nuclear antigens. In all these clinical groups, we revealed close correlations between concentrations of autoantibodies, FoxP3+T-regulatory lymphocyte scores, and parameters of carbohydrate and lipid metabolism. The results, obtained in present study, allow us to suggest that metabolic disturbances may be associated with altered immune tolerance mechanisms and activation of humoral immune response that are detectable since early stages of the disease and may contribute to development of complications occurring in diabetes mellitus type 2.
format	article
author	I. V. Kologrivova T. E. Suslova O. A. Koshelskaya I. V. Vinnizkaya O. A. Trubacheva N. M. Zheltonogova A. M. Gusakova
author_facet	I. V. Kologrivova T. E. Suslova O. A. Koshelskaya I. V. Vinnizkaya O. A. Trubacheva N. M. Zheltonogova A. M. Gusakova
author_sort	I. V. Kologrivova
title	FOXP3+T-REGULATORY LYMPHOCYTES AND AUTOANTIBODIES IN PATIENTS WITH ARTERIAL HYPERTENSION, ASSOCIATED WITH DIABETES MELLITUS TYPE 2 AND IMPAIRED GLUCOSE TOLERANCE
title_short	FOXP3+T-REGULATORY LYMPHOCYTES AND AUTOANTIBODIES IN PATIENTS WITH ARTERIAL HYPERTENSION, ASSOCIATED WITH DIABETES MELLITUS TYPE 2 AND IMPAIRED GLUCOSE TOLERANCE
title_full	FOXP3+T-REGULATORY LYMPHOCYTES AND AUTOANTIBODIES IN PATIENTS WITH ARTERIAL HYPERTENSION, ASSOCIATED WITH DIABETES MELLITUS TYPE 2 AND IMPAIRED GLUCOSE TOLERANCE
title_fullStr	FOXP3+T-REGULATORY LYMPHOCYTES AND AUTOANTIBODIES IN PATIENTS WITH ARTERIAL HYPERTENSION, ASSOCIATED WITH DIABETES MELLITUS TYPE 2 AND IMPAIRED GLUCOSE TOLERANCE
title_full_unstemmed	FOXP3+T-REGULATORY LYMPHOCYTES AND AUTOANTIBODIES IN PATIENTS WITH ARTERIAL HYPERTENSION, ASSOCIATED WITH DIABETES MELLITUS TYPE 2 AND IMPAIRED GLUCOSE TOLERANCE
title_sort	foxp3+t-regulatory lymphocytes and autoantibodies in patients with arterial hypertension, associated with diabetes mellitus type 2 and impaired glucose tolerance
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/419c1910c30e4a81b8c61f3c48141fef
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FOXP3+T-REGULATORY LYMPHOCYTES AND AUTOANTIBODIES IN PATIENTS WITH ARTERIAL HYPERTENSION, ASSOCIATED WITH DIABETES MELLITUS TYPE 2 AND IMPAIRED GLUCOSE TOLERANCE

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