Extracellular matrix protein-1 secretory isoform promotes ovarian cancer through increasing alternative mRNA splicing and stemness

Extracellular matrix protein 1 (ECM1) has been associated with cancer but the underlying molecular mechanisms are not clear. Here, the authors show that while ECM1b isoform is a tumour suppressor, the secreted isoform ECM1a promotes tumourigenesis and chemoresistance through increasing stemness and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Huijing Yin, Jingshu Wang, Hui Li, Yinjue Yu, Xiaoling Wang, Lili Lu, Cuiting Lv, Bin Chang, Wei Jin, Wenwen Guo, Chunxia Ren, Gong Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/41a27b0805ba488cbcc1378ad73cf84a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:41a27b0805ba488cbcc1378ad73cf84a
record_format	dspace
spelling	oai:doaj.org-article:41a27b0805ba488cbcc1378ad73cf84a2021-12-02T16:14:49ZExtracellular matrix protein-1 secretory isoform promotes ovarian cancer through increasing alternative mRNA splicing and stemness10.1038/s41467-021-24315-12041-1723https://doaj.org/article/41a27b0805ba488cbcc1378ad73cf84a2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24315-1https://doaj.org/toc/2041-1723Extracellular matrix protein 1 (ECM1) has been associated with cancer but the underlying molecular mechanisms are not clear. Here, the authors show that while ECM1b isoform is a tumour suppressor, the secreted isoform ECM1a promotes tumourigenesis and chemoresistance through increasing stemness and alternative mRNA splicing in ovarian cancer.Huijing YinJingshu WangHui LiYinjue YuXiaoling WangLili LuCuiting LvBin ChangWei JinWenwen GuoChunxia RenGong YangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huijing Yin Jingshu Wang Hui Li Yinjue Yu Xiaoling Wang Lili Lu Cuiting Lv Bin Chang Wei Jin Wenwen Guo Chunxia Ren Gong Yang Extracellular matrix protein-1 secretory isoform promotes ovarian cancer through increasing alternative mRNA splicing and stemness
description	Extracellular matrix protein 1 (ECM1) has been associated with cancer but the underlying molecular mechanisms are not clear. Here, the authors show that while ECM1b isoform is a tumour suppressor, the secreted isoform ECM1a promotes tumourigenesis and chemoresistance through increasing stemness and alternative mRNA splicing in ovarian cancer.
format	article
author	Huijing Yin Jingshu Wang Hui Li Yinjue Yu Xiaoling Wang Lili Lu Cuiting Lv Bin Chang Wei Jin Wenwen Guo Chunxia Ren Gong Yang
author_facet	Huijing Yin Jingshu Wang Hui Li Yinjue Yu Xiaoling Wang Lili Lu Cuiting Lv Bin Chang Wei Jin Wenwen Guo Chunxia Ren Gong Yang
author_sort	Huijing Yin
title	Extracellular matrix protein-1 secretory isoform promotes ovarian cancer through increasing alternative mRNA splicing and stemness
title_short	Extracellular matrix protein-1 secretory isoform promotes ovarian cancer through increasing alternative mRNA splicing and stemness
title_full	Extracellular matrix protein-1 secretory isoform promotes ovarian cancer through increasing alternative mRNA splicing and stemness
title_fullStr	Extracellular matrix protein-1 secretory isoform promotes ovarian cancer through increasing alternative mRNA splicing and stemness
title_full_unstemmed	Extracellular matrix protein-1 secretory isoform promotes ovarian cancer through increasing alternative mRNA splicing and stemness
title_sort	extracellular matrix protein-1 secretory isoform promotes ovarian cancer through increasing alternative mrna splicing and stemness
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/41a27b0805ba488cbcc1378ad73cf84a
work_keys_str_mv	AT huijingyin extracellularmatrixprotein1secretoryisoformpromotesovariancancerthroughincreasingalternativemrnasplicingandstemness AT jingshuwang extracellularmatrixprotein1secretoryisoformpromotesovariancancerthroughincreasingalternativemrnasplicingandstemness AT huili extracellularmatrixprotein1secretoryisoformpromotesovariancancerthroughincreasingalternativemrnasplicingandstemness AT yinjueyu extracellularmatrixprotein1secretoryisoformpromotesovariancancerthroughincreasingalternativemrnasplicingandstemness AT xiaolingwang extracellularmatrixprotein1secretoryisoformpromotesovariancancerthroughincreasingalternativemrnasplicingandstemness AT lililu extracellularmatrixprotein1secretoryisoformpromotesovariancancerthroughincreasingalternativemrnasplicingandstemness AT cuitinglv extracellularmatrixprotein1secretoryisoformpromotesovariancancerthroughincreasingalternativemrnasplicingandstemness AT binchang extracellularmatrixprotein1secretoryisoformpromotesovariancancerthroughincreasingalternativemrnasplicingandstemness AT weijin extracellularmatrixprotein1secretoryisoformpromotesovariancancerthroughincreasingalternativemrnasplicingandstemness AT wenwenguo extracellularmatrixprotein1secretoryisoformpromotesovariancancerthroughincreasingalternativemrnasplicingandstemness AT chunxiaren extracellularmatrixprotein1secretoryisoformpromotesovariancancerthroughincreasingalternativemrnasplicingandstemness AT gongyang extracellularmatrixprotein1secretoryisoformpromotesovariancancerthroughincreasingalternativemrnasplicingandstemness
_version_	1718384286836457472

Extracellular matrix protein-1 secretory isoform promotes ovarian cancer through increasing alternative mRNA splicing and stemness

Ejemplares similares