EFFECT OF NIGELLA SATIVA ON SERUM TESTOSTERONE LEVELS IN LETROZOLE INDUCED POLYCYSTIC OVARIAN SYNDROME IN MICE

Objective: Monitor the ameliorative impact of Nigella sativa on fasting blood glucose and serum testosterone levels in polycystic ovarian syndrome caused by letrozole in mice. Study Design: Laboratory based randomized control trial. Place and Duration of Study: Anatomy department, Army Medical Colle...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Noreen Anwar, Shabnam Hamid, Amer Nadeem, Ayesha Asad, Naureen Waseem, Nomana Mehmood
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	fasting blood glucose letrozole nigella sativa polycystic ovarian syndrome serum testosterone level Medicine R Medicine (General) R5-920
Acceso en línea:	https://doi.org/10.51253/pafmj.v71i1.3693 https://doaj.org/article/41a3a84006c346d7ba6818cda0869025
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:41a3a84006c346d7ba6818cda0869025
record_format	dspace
spelling	oai:doaj.org-article:41a3a84006c346d7ba6818cda08690252021-12-02T19:03:20ZEFFECT OF NIGELLA SATIVA ON SERUM TESTOSTERONE LEVELS IN LETROZOLE INDUCED POLYCYSTIC OVARIAN SYNDROME IN MICEhttps://doi.org/10.51253/pafmj.v71i1.36930030-96482411-8842https://doaj.org/article/41a3a84006c346d7ba6818cda08690252021-02-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/3693https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: Monitor the ameliorative impact of Nigella sativa on fasting blood glucose and serum testosterone levels in polycystic ovarian syndrome caused by letrozole in mice. Study Design: Laboratory based randomized control trial. Place and Duration of Study: Anatomy department, Army Medical College in teamwork with National Institute of Health. Time span is Dec 2014 Dec 2015. Methodology: Total 40 mature female BALB/c mice were chosen and distributed in four groups (ten mice in each one). Group 1 was given normal diet. Rests of three groups were treated with Letrozole at dose of 1 mg/kg body weight once daily for eight weeks. Group 3 was also given Nigella sativa seeds powder at dose of 10 g/kg body weight once daily starting at 22 day and continued up to eight weeks. Group 4 was treated with Nigella sativa oil at a dose of 4 ml/kg body weight once daily starting at 22 day and continued up to eight weeks. At termination of trial, fasting blood glucose level (FBG) was recorded by taking blood sample by glucometer from mouse lateral tail vein after 12 hours fasting. Mice with blood glucose level 250-464 mg/dl were marked hyperglycemic. Final blood sample was taken through cardiac puncture for serum testosterone evaluation. Results: Fasting blood glucose and Serum testosterone levels were raised in group 2 animals in comparison to group 1 while they were reduced remarkably in group 3 and 4 in comparison of group 2. Conclusion: Nigella sativa seeds in both solid and liquid state leave an identical curative impact on fasting blood glucose and serum testosterone levels in polycystic ovarian syndrome in mice.Noreen AnwarShabnam HamidAmer NadeemAyesha AsadNaureen WaseemNomana MehmoodArmy Medical College Rawalpindiarticlefasting blood glucoseletrozolenigella sativapolycystic ovarian syndromeserum testosterone levelMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 1, Pp 338-342 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fasting blood glucose letrozole nigella sativa polycystic ovarian syndrome serum testosterone level Medicine R Medicine (General) R5-920
spellingShingle	fasting blood glucose letrozole nigella sativa polycystic ovarian syndrome serum testosterone level Medicine R Medicine (General) R5-920 Noreen Anwar Shabnam Hamid Amer Nadeem Ayesha Asad Naureen Waseem Nomana Mehmood EFFECT OF NIGELLA SATIVA ON SERUM TESTOSTERONE LEVELS IN LETROZOLE INDUCED POLYCYSTIC OVARIAN SYNDROME IN MICE
description	Objective: Monitor the ameliorative impact of Nigella sativa on fasting blood glucose and serum testosterone levels in polycystic ovarian syndrome caused by letrozole in mice. Study Design: Laboratory based randomized control trial. Place and Duration of Study: Anatomy department, Army Medical College in teamwork with National Institute of Health. Time span is Dec 2014 Dec 2015. Methodology: Total 40 mature female BALB/c mice were chosen and distributed in four groups (ten mice in each one). Group 1 was given normal diet. Rests of three groups were treated with Letrozole at dose of 1 mg/kg body weight once daily for eight weeks. Group 3 was also given Nigella sativa seeds powder at dose of 10 g/kg body weight once daily starting at 22 day and continued up to eight weeks. Group 4 was treated with Nigella sativa oil at a dose of 4 ml/kg body weight once daily starting at 22 day and continued up to eight weeks. At termination of trial, fasting blood glucose level (FBG) was recorded by taking blood sample by glucometer from mouse lateral tail vein after 12 hours fasting. Mice with blood glucose level 250-464 mg/dl were marked hyperglycemic. Final blood sample was taken through cardiac puncture for serum testosterone evaluation. Results: Fasting blood glucose and Serum testosterone levels were raised in group 2 animals in comparison to group 1 while they were reduced remarkably in group 3 and 4 in comparison of group 2. Conclusion: Nigella sativa seeds in both solid and liquid state leave an identical curative impact on fasting blood glucose and serum testosterone levels in polycystic ovarian syndrome in mice.
format	article
author	Noreen Anwar Shabnam Hamid Amer Nadeem Ayesha Asad Naureen Waseem Nomana Mehmood
author_facet	Noreen Anwar Shabnam Hamid Amer Nadeem Ayesha Asad Naureen Waseem Nomana Mehmood
author_sort	Noreen Anwar
title	EFFECT OF NIGELLA SATIVA ON SERUM TESTOSTERONE LEVELS IN LETROZOLE INDUCED POLYCYSTIC OVARIAN SYNDROME IN MICE
title_short	EFFECT OF NIGELLA SATIVA ON SERUM TESTOSTERONE LEVELS IN LETROZOLE INDUCED POLYCYSTIC OVARIAN SYNDROME IN MICE
title_full	EFFECT OF NIGELLA SATIVA ON SERUM TESTOSTERONE LEVELS IN LETROZOLE INDUCED POLYCYSTIC OVARIAN SYNDROME IN MICE
title_fullStr	EFFECT OF NIGELLA SATIVA ON SERUM TESTOSTERONE LEVELS IN LETROZOLE INDUCED POLYCYSTIC OVARIAN SYNDROME IN MICE
title_full_unstemmed	EFFECT OF NIGELLA SATIVA ON SERUM TESTOSTERONE LEVELS IN LETROZOLE INDUCED POLYCYSTIC OVARIAN SYNDROME IN MICE
title_sort	effect of nigella sativa on serum testosterone levels in letrozole induced polycystic ovarian syndrome in mice
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doi.org/10.51253/pafmj.v71i1.3693 https://doaj.org/article/41a3a84006c346d7ba6818cda0869025
work_keys_str_mv	AT noreenanwar effectofnigellasativaonserumtestosteronelevelsinletrozoleinducedpolycysticovariansyndromeinmice AT shabnamhamid effectofnigellasativaonserumtestosteronelevelsinletrozoleinducedpolycysticovariansyndromeinmice AT amernadeem effectofnigellasativaonserumtestosteronelevelsinletrozoleinducedpolycysticovariansyndromeinmice AT ayeshaasad effectofnigellasativaonserumtestosteronelevelsinletrozoleinducedpolycysticovariansyndromeinmice AT naureenwaseem effectofnigellasativaonserumtestosteronelevelsinletrozoleinducedpolycysticovariansyndromeinmice AT nomanamehmood effectofnigellasativaonserumtestosteronelevelsinletrozoleinducedpolycysticovariansyndromeinmice
_version_	1718377205026783232

EFFECT OF NIGELLA SATIVA ON SERUM TESTOSTERONE LEVELS IN LETROZOLE INDUCED POLYCYSTIC OVARIAN SYNDROME IN MICE

Ejemplares similares