Omega-3 fatty acids: potential role in the management of early Alzheimer’s disease

Gregory A Jicha, William R MarkesberyUniversity of Kentucky Alzheimer’s Disease Center and the Sanders-Brown Center on Aging University of Kentucky College of Medicine, Lexington, KY, USAbstract: Omega-3 fatty acids are essential for brain growth and development. They play an important rol...

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Autores principales: Gregory A Jicha, William R Markesbery
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2010
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Acceso en línea:https://doaj.org/article/41a54e102aaf425891b830bbc5f4e9a6
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spelling oai:doaj.org-article:41a54e102aaf425891b830bbc5f4e9a62021-12-02T07:05:30ZOmega-3 fatty acids: potential role in the management of early Alzheimer’s disease1178-1998https://doaj.org/article/41a54e102aaf425891b830bbc5f4e9a62010-03-01T00:00:00Zhttps://www.dovepress.com/omega-3-fatty-acids-potential-role-in-the-management-of-early-alzheime-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Gregory A Jicha, William R MarkesberyUniversity of Kentucky Alzheimer’s Disease Center and the Sanders-Brown Center on Aging University of Kentucky College of Medicine, Lexington, KY, USAbstract: Omega-3 fatty acids are essential for brain growth and development. They play an important role throughout life, as critical modulators of neuronal function and regulation of oxidative stress mechanisms, in brain health and disease. Docosahexanoic acid (DHA), the major omega-3 fatty acid found in neurons, has taken on a central role as a target for therapeutic intervention in Alzheimer’s disease (AD). A plethora of in vitro, animal model, and human data, gathered over the past decade, highlight the important role DHA may play in the development of a variety of neurological and psychiatric disorders, including AD. Cross sectional and prospective cohort data have demonstrated that reduced dietary intake or low brain levels of DHA are associated with accelerated cognitive decline or the development of incipient dementia, including AD. Several clinical trials investigating the effects of omega-3 fatty acid supplementation in AD have been completed and all failed to demonstrate its efficacy in the treatment of AD. However, these trials produced intriguing data suggesting that the beneficial effects of omega-3 fatty acid supplementation may depend on the stage of disease, other dietary mediators, and apolipoprotein E status.Keywords: Alzheimer’s disease, omega-3 fatty acids, oxidative stress, clinical studies, treatmentGregory A JichaWilliam R MarkesberyDove Medical PressarticleAlzheimer's diseaseOmega-3 fatty acidsoxidative stressclinical studiestreatmentGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 5, Pp 45-61 (2010)
institution DOAJ
collection DOAJ
language EN
topic Alzheimer's disease
Omega-3 fatty acids
oxidative stress
clinical studies
treatment
Geriatrics
RC952-954.6
spellingShingle Alzheimer's disease
Omega-3 fatty acids
oxidative stress
clinical studies
treatment
Geriatrics
RC952-954.6
Gregory A Jicha
William R Markesbery
Omega-3 fatty acids: potential role in the management of early Alzheimer’s disease
description Gregory A Jicha, William R MarkesberyUniversity of Kentucky Alzheimer’s Disease Center and the Sanders-Brown Center on Aging University of Kentucky College of Medicine, Lexington, KY, USAbstract: Omega-3 fatty acids are essential for brain growth and development. They play an important role throughout life, as critical modulators of neuronal function and regulation of oxidative stress mechanisms, in brain health and disease. Docosahexanoic acid (DHA), the major omega-3 fatty acid found in neurons, has taken on a central role as a target for therapeutic intervention in Alzheimer’s disease (AD). A plethora of in vitro, animal model, and human data, gathered over the past decade, highlight the important role DHA may play in the development of a variety of neurological and psychiatric disorders, including AD. Cross sectional and prospective cohort data have demonstrated that reduced dietary intake or low brain levels of DHA are associated with accelerated cognitive decline or the development of incipient dementia, including AD. Several clinical trials investigating the effects of omega-3 fatty acid supplementation in AD have been completed and all failed to demonstrate its efficacy in the treatment of AD. However, these trials produced intriguing data suggesting that the beneficial effects of omega-3 fatty acid supplementation may depend on the stage of disease, other dietary mediators, and apolipoprotein E status.Keywords: Alzheimer’s disease, omega-3 fatty acids, oxidative stress, clinical studies, treatment
format article
author Gregory A Jicha
William R Markesbery
author_facet Gregory A Jicha
William R Markesbery
author_sort Gregory A Jicha
title Omega-3 fatty acids: potential role in the management of early Alzheimer’s disease
title_short Omega-3 fatty acids: potential role in the management of early Alzheimer’s disease
title_full Omega-3 fatty acids: potential role in the management of early Alzheimer’s disease
title_fullStr Omega-3 fatty acids: potential role in the management of early Alzheimer’s disease
title_full_unstemmed Omega-3 fatty acids: potential role in the management of early Alzheimer’s disease
title_sort omega-3 fatty acids: potential role in the management of early alzheimer’s disease
publisher Dove Medical Press
publishDate 2010
url https://doaj.org/article/41a54e102aaf425891b830bbc5f4e9a6
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AT williamrmarkesbery omega3fattyacidspotentialroleinthemanagementofearlyalzheimerrsquosdisease
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