THE CHANGES OF OF CELLULAR IMMUNITY PARAMETERS IN PATIENTS WITH PREINVASIVE AND MICROINVASIVE CERVICAL CANCER BEFORE AND AFTER TREATMENT

Abstract. The comparative study of immunocompetent cells’ phenotype was performed in patients with the preinvasive and microinvasive cervical cancer before and after the treatment. Besides, the study of importance of selected cellular immunity indices as a predicitive factors of effective surgical t...

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Autores principales:	P. I. Kovchur, E. V. Bahidze, A. V. Yastrebova
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	cervical cancer regulatory cells human papillomavirus Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/41a5d5737f19403184e82238a85be113
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spelling	oai:doaj.org-article:41a5d5737f19403184e82238a85be1132021-11-22T07:09:46ZTHE CHANGES OF OF CELLULAR IMMUNITY PARAMETERS IN PATIENTS WITH PREINVASIVE AND MICROINVASIVE CERVICAL CANCER BEFORE AND AFTER TREATMENT2220-76192313-739810.15789/2220-7619-2014-2-173-180https://doaj.org/article/41a5d5737f19403184e82238a85be1132014-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/169https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. The comparative study of immunocompetent cells’ phenotype was performed in patients with the preinvasive and microinvasive cervical cancer before and after the treatment. Besides, the study of importance of selected cellular immunity indices as a predicitive factors of effective surgical treatment in a combination with immunotherapy (the study group) in comparison with a surgical treatment only (the control group) have been conducted. The true numerical normalization of subpopulation composition of peripheral blood lymphocyte has been determined including the expression level of suppressor lymphocytes molecular markers (FOXP3 и TGF-β1) and the expression level of CD95-marker in a study group in comparison with a control group. Moreover, true decrease of HPV (human papillomavirus) — positive patients (1.7%) and the absence of E7 oncoprotein in the study group have been discovered.P. I. KovchurE. V. BahidzeA. V. YastrebovaSankt-Peterburg : NIIÈM imeni Pasteraarticlecervical cancerregulatory cellshuman papillomavirusInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 4, Iss 2, Pp 173-180 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	cervical cancer regulatory cells human papillomavirus Infectious and parasitic diseases RC109-216
spellingShingle	cervical cancer regulatory cells human papillomavirus Infectious and parasitic diseases RC109-216 P. I. Kovchur E. V. Bahidze A. V. Yastrebova THE CHANGES OF OF CELLULAR IMMUNITY PARAMETERS IN PATIENTS WITH PREINVASIVE AND MICROINVASIVE CERVICAL CANCER BEFORE AND AFTER TREATMENT
description	Abstract. The comparative study of immunocompetent cells’ phenotype was performed in patients with the preinvasive and microinvasive cervical cancer before and after the treatment. Besides, the study of importance of selected cellular immunity indices as a predicitive factors of effective surgical treatment in a combination with immunotherapy (the study group) in comparison with a surgical treatment only (the control group) have been conducted. The true numerical normalization of subpopulation composition of peripheral blood lymphocyte has been determined including the expression level of suppressor lymphocytes molecular markers (FOXP3 и TGF-β1) and the expression level of CD95-marker in a study group in comparison with a control group. Moreover, true decrease of HPV (human papillomavirus) — positive patients (1.7%) and the absence of E7 oncoprotein in the study group have been discovered.
format	article
author	P. I. Kovchur E. V. Bahidze A. V. Yastrebova
author_facet	P. I. Kovchur E. V. Bahidze A. V. Yastrebova
author_sort	P. I. Kovchur
title	THE CHANGES OF OF CELLULAR IMMUNITY PARAMETERS IN PATIENTS WITH PREINVASIVE AND MICROINVASIVE CERVICAL CANCER BEFORE AND AFTER TREATMENT
title_short	THE CHANGES OF OF CELLULAR IMMUNITY PARAMETERS IN PATIENTS WITH PREINVASIVE AND MICROINVASIVE CERVICAL CANCER BEFORE AND AFTER TREATMENT
title_full	THE CHANGES OF OF CELLULAR IMMUNITY PARAMETERS IN PATIENTS WITH PREINVASIVE AND MICROINVASIVE CERVICAL CANCER BEFORE AND AFTER TREATMENT
title_fullStr	THE CHANGES OF OF CELLULAR IMMUNITY PARAMETERS IN PATIENTS WITH PREINVASIVE AND MICROINVASIVE CERVICAL CANCER BEFORE AND AFTER TREATMENT
title_full_unstemmed	THE CHANGES OF OF CELLULAR IMMUNITY PARAMETERS IN PATIENTS WITH PREINVASIVE AND MICROINVASIVE CERVICAL CANCER BEFORE AND AFTER TREATMENT
title_sort	changes of of cellular immunity parameters in patients with preinvasive and microinvasive cervical cancer before and after treatment
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/41a5d5737f19403184e82238a85be113
work_keys_str_mv	AT pikovchur thechangesofofcellularimmunityparametersinpatientswithpreinvasiveandmicroinvasivecervicalcancerbeforeandaftertreatment AT evbahidze thechangesofofcellularimmunityparametersinpatientswithpreinvasiveandmicroinvasivecervicalcancerbeforeandaftertreatment AT avyastrebova thechangesofofcellularimmunityparametersinpatientswithpreinvasiveandmicroinvasivecervicalcancerbeforeandaftertreatment AT pikovchur changesofofcellularimmunityparametersinpatientswithpreinvasiveandmicroinvasivecervicalcancerbeforeandaftertreatment AT evbahidze changesofofcellularimmunityparametersinpatientswithpreinvasiveandmicroinvasivecervicalcancerbeforeandaftertreatment AT avyastrebova changesofofcellularimmunityparametersinpatientswithpreinvasiveandmicroinvasivecervicalcancerbeforeandaftertreatment
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THE CHANGES OF OF CELLULAR IMMUNITY PARAMETERS IN PATIENTS WITH PREINVASIVE AND MICROINVASIVE CERVICAL CANCER BEFORE AND AFTER TREATMENT

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