Regio- and enantioselective umpolung gem-difluoroallylation of hydrazones via palladium catalysis enabled by N-heterocyclic carbene ligand

Installation of difluoroalkyl groups while also imparting stereochemical information is mostly only possible with organocatalytic methods that activate carbonyls. Here the authors show a method to perform an difluoroallylation of hydrazones, forming a masked amine stereocenter, via palladium- and N-...

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Autores principales:	Shuai Huang, Fei-Fei Tong, Da-Chang Bai, Gao-Peng Zhang, Yang-Jie Jiang, Bo Zhang, Xuebing Leng, Ying-Long Guo, Xiao-Long Wan, Xingang Zhang, Chang-Hua Ding, Xue-Long Hou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/41a5e97b879a423fa0da4d0267aedd85
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spelling	oai:doaj.org-article:41a5e97b879a423fa0da4d0267aedd852021-11-14T12:36:26ZRegio- and enantioselective umpolung gem-difluoroallylation of hydrazones via palladium catalysis enabled by N-heterocyclic carbene ligand10.1038/s41467-021-26667-02041-1723https://doaj.org/article/41a5e97b879a423fa0da4d0267aedd852021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26667-0https://doaj.org/toc/2041-1723Installation of difluoroalkyl groups while also imparting stereochemical information is mostly only possible with organocatalytic methods that activate carbonyls. Here the authors show a method to perform an difluoroallylation of hydrazones, forming a masked amine stereocenter, via palladium- and N-heterocyclic-carbene catalysis.Shuai HuangFei-Fei TongDa-Chang BaiGao-Peng ZhangYang-Jie JiangBo ZhangXuebing LengYing-Long GuoXiao-Long WanXingang ZhangChang-Hua DingXue-Long HouNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shuai Huang Fei-Fei Tong Da-Chang Bai Gao-Peng Zhang Yang-Jie Jiang Bo Zhang Xuebing Leng Ying-Long Guo Xiao-Long Wan Xingang Zhang Chang-Hua Ding Xue-Long Hou Regio- and enantioselective umpolung gem-difluoroallylation of hydrazones via palladium catalysis enabled by N-heterocyclic carbene ligand
description	Installation of difluoroalkyl groups while also imparting stereochemical information is mostly only possible with organocatalytic methods that activate carbonyls. Here the authors show a method to perform an difluoroallylation of hydrazones, forming a masked amine stereocenter, via palladium- and N-heterocyclic-carbene catalysis.
format	article
author	Shuai Huang Fei-Fei Tong Da-Chang Bai Gao-Peng Zhang Yang-Jie Jiang Bo Zhang Xuebing Leng Ying-Long Guo Xiao-Long Wan Xingang Zhang Chang-Hua Ding Xue-Long Hou
author_facet	Shuai Huang Fei-Fei Tong Da-Chang Bai Gao-Peng Zhang Yang-Jie Jiang Bo Zhang Xuebing Leng Ying-Long Guo Xiao-Long Wan Xingang Zhang Chang-Hua Ding Xue-Long Hou
author_sort	Shuai Huang
title	Regio- and enantioselective umpolung gem-difluoroallylation of hydrazones via palladium catalysis enabled by N-heterocyclic carbene ligand
title_short	Regio- and enantioselective umpolung gem-difluoroallylation of hydrazones via palladium catalysis enabled by N-heterocyclic carbene ligand
title_full	Regio- and enantioselective umpolung gem-difluoroallylation of hydrazones via palladium catalysis enabled by N-heterocyclic carbene ligand
title_fullStr	Regio- and enantioselective umpolung gem-difluoroallylation of hydrazones via palladium catalysis enabled by N-heterocyclic carbene ligand
title_full_unstemmed	Regio- and enantioselective umpolung gem-difluoroallylation of hydrazones via palladium catalysis enabled by N-heterocyclic carbene ligand
title_sort	regio- and enantioselective umpolung gem-difluoroallylation of hydrazones via palladium catalysis enabled by n-heterocyclic carbene ligand
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/41a5e97b879a423fa0da4d0267aedd85
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Regio- and enantioselective umpolung gem-difluoroallylation of hydrazones via palladium catalysis enabled by N-heterocyclic carbene ligand

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