A comprehensive breath test that confirms recent use of inhaled cannabis within the impairment window

Abstract Legalization of cannabis for medicinal and/or recreational use is expanding globally. Although cannabis is being regulated country by country, an accurate recent use test with indisputable results correlated with impairment has yet to be discovered. In the present study, a new approach for...

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Autores principales:	Michael W. DeGregorio, Gregory T. Wurz, Edward Montoya, Chiao-Jung Kao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/41a7a47b9cf6453e8dcfd923db16f869
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spelling	oai:doaj.org-article:41a7a47b9cf6453e8dcfd923db16f8692021-11-28T12:15:40ZA comprehensive breath test that confirms recent use of inhaled cannabis within the impairment window10.1038/s41598-021-02137-x2045-2322https://doaj.org/article/41a7a47b9cf6453e8dcfd923db16f8692021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02137-xhttps://doaj.org/toc/2045-2322Abstract Legalization of cannabis for medicinal and/or recreational use is expanding globally. Although cannabis is being regulated country by country, an accurate recent use test with indisputable results correlated with impairment has yet to be discovered. In the present study, a new approach for determining recent cannabis use within the impairment window after smoking was developed by studying 74 subjects with a mean age of 25 years and average use history of 9 years. Horizontal gaze nystagmus was evaluated along with subject self-assessments of impairment, and blood and breath samples were collected before and after smoking cannabis. Breath and blood pharmacokinetic parameters and cannabinoid profiles determined recent use within the impairment window. No subjects were positive for recent use pre-smoking, although all subjects had detectable cannabinoids in breath samples. We describe an inhaled cannabis recent use test that correlates with impairment and helps protect against wrongful prosecution and workplace discrimination.Michael W. DeGregorioGregory T. WurzEdward MontoyaChiao-Jung KaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michael W. DeGregorio Gregory T. Wurz Edward Montoya Chiao-Jung Kao A comprehensive breath test that confirms recent use of inhaled cannabis within the impairment window
description	Abstract Legalization of cannabis for medicinal and/or recreational use is expanding globally. Although cannabis is being regulated country by country, an accurate recent use test with indisputable results correlated with impairment has yet to be discovered. In the present study, a new approach for determining recent cannabis use within the impairment window after smoking was developed by studying 74 subjects with a mean age of 25 years and average use history of 9 years. Horizontal gaze nystagmus was evaluated along with subject self-assessments of impairment, and blood and breath samples were collected before and after smoking cannabis. Breath and blood pharmacokinetic parameters and cannabinoid profiles determined recent use within the impairment window. No subjects were positive for recent use pre-smoking, although all subjects had detectable cannabinoids in breath samples. We describe an inhaled cannabis recent use test that correlates with impairment and helps protect against wrongful prosecution and workplace discrimination.
format	article
author	Michael W. DeGregorio Gregory T. Wurz Edward Montoya Chiao-Jung Kao
author_facet	Michael W. DeGregorio Gregory T. Wurz Edward Montoya Chiao-Jung Kao
author_sort	Michael W. DeGregorio
title	A comprehensive breath test that confirms recent use of inhaled cannabis within the impairment window
title_short	A comprehensive breath test that confirms recent use of inhaled cannabis within the impairment window
title_full	A comprehensive breath test that confirms recent use of inhaled cannabis within the impairment window
title_fullStr	A comprehensive breath test that confirms recent use of inhaled cannabis within the impairment window
title_full_unstemmed	A comprehensive breath test that confirms recent use of inhaled cannabis within the impairment window
title_sort	comprehensive breath test that confirms recent use of inhaled cannabis within the impairment window
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/41a7a47b9cf6453e8dcfd923db16f869
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A comprehensive breath test that confirms recent use of inhaled cannabis within the impairment window

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