Regarding optical coherence tomography grading of ischemia in central retinal venous occlusion

Koushik TripathyDepartment of Vitreoretina and Uvea, ICARE Eye Hospital & Postgraduate Institute, Noida, Uttar Pradesh, IndiaThe author read with interest the article by Browning et al.1 The author humbly wants to discuss a few facts.1. The article1 discusses grading of retinal ischemia base...

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Autor principal:	Tripathy K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	OCT central retinal artery occlusion neovascularization of iris neovascularization of the anterior chamber angle Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/41a915580da94720bdcaeacad40760a0
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id	oai:doaj.org-article:41a915580da94720bdcaeacad40760a0
record_format	dspace
institution	DOAJ
collection	DOAJ
language	EN
topic	OCT central retinal artery occlusion neovascularization of iris neovascularization of the anterior chamber angle Ophthalmology RE1-994
spellingShingle	OCT central retinal artery occlusion neovascularization of iris neovascularization of the anterior chamber angle Ophthalmology RE1-994 Tripathy K Regarding optical coherence tomography grading of ischemia in central retinal venous occlusion
description	Koushik TripathyDepartment of Vitreoretina and Uvea, ICARE Eye Hospital & Postgraduate Institute, Noida, Uttar Pradesh, IndiaThe author read with interest the article by Browning et al.1 The author humbly wants to discuss a few facts.1. The article1 discusses grading of retinal ischemia based on optical coherence tomography features in central retinal venous occlusion. As coexisting central retinal arterial occlusion or cilioretinal arterial occlusion may also cause inner retinal hyper-reflectivity, exclusion of such cases is an important consideration before implicating central retinal venous occlusion for the ischemia. Extensive intraretinal hemorrhages are other important hindrances to the evaluation of the perfusion status of the retina using both fluorescein angiogram and optical coherence tomography.2. It would be interesting to know the gonioscopic findings, especially neovascularization of the anterior chamber angle if it was performed at presentation and during the follow-ups.3. The manuscript documented that the incidence of anterior segment neovascularization at 1 year was 8.9% in severe ischemia group.1 The incidence of anterior segment neovascularization in perfused groups was higher (15.4% and 17.6% for mild and moderate ischemia, respectively). Although the sample size was low, such findings are contrary to the literature2 and require further discussion. Authors' replyDavid J Browning, Omar S Punjabi, Chong LeeDepartment of Ophthalmology, Charlotte Eye, Ear, Nose and Throat Associates, P.A., Charlotte, NC, USA We thank Dr Tripathy for his interest in our article and would respond to his above-mentioned points.1. We agree that excluding eyes with cilioretinal artery and central retinal artery occlusions is necessary to be able to attribute inner retinal reflectivity changes to central retinal vein occlusion. Cilioretinal artery occlusion is associated with a band of ischemic retinal whitening and central retinal artery occlusion more generalized posterior-pole ischemic whitening. Neither was present in any of our patients. The changes in inner retinal reflectivity were present without visible whitening.The confounding effects of intraretinal hemorrhage were recognized and accounted for as found in the following sentence in “Methods” section: “When there was concomitant intraretinal hemorrhage, the grading was done based on a zone without intraretinal hemorrhage if one was present, but if intraretinal hemorrhage was confluent, the inner retina was hyperreflective and delineation of layers was obscured by the hemorrhage, such cases were graded as severe ischemia”.2. This was a retrospective study drawn from two retina specialists (DJB and OSP). There was no standardization about when gonioscopy was performed. Therefore, the development of anterior segment neovascularization (ASNV) may have been underestimated relative to a figure derived from a systematic prospective study in which gonioscopy would be uniformly performed before pupillary dilation.3. The incidence of ASNV recorded in Table 2 of the manuscript was confounded by the frequent injection of antivascular endothelial growth factor drugs for macular edema in all three groups. As we wrote in the “Discussion” section: “The frequent injection of anti-VEGF drugs not only treated the macular edema but also probably masked any underlying associations of ASNV and NVG with baseline ischemia”.View the original paper by Browning et al.
format	article
author	Tripathy K
author_facet	Tripathy K
author_sort	Tripathy K
title	Regarding optical coherence tomography grading of ischemia in central retinal venous occlusion
title_short	Regarding optical coherence tomography grading of ischemia in central retinal venous occlusion
title_full	Regarding optical coherence tomography grading of ischemia in central retinal venous occlusion
title_fullStr	Regarding optical coherence tomography grading of ischemia in central retinal venous occlusion
title_full_unstemmed	Regarding optical coherence tomography grading of ischemia in central retinal venous occlusion
title_sort	regarding optical coherence tomography grading of ischemia in central retinal venous occlusion
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/41a915580da94720bdcaeacad40760a0
work_keys_str_mv	AT tripathyk regardingopticalcoherencetomographygradingofischemiaincentralretinalvenousocclusion
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spelling	oai:doaj.org-article:41a915580da94720bdcaeacad40760a02021-12-02T00:21:57ZRegarding optical coherence tomography grading of ischemia in central retinal venous occlusion1177-5483https://doaj.org/article/41a915580da94720bdcaeacad40760a02017-02-01T00:00:00Zhttps://www.dovepress.com/regarding-optical-coherence-tomography-grading-of-ischemia-in-central--peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Koushik TripathyDepartment of Vitreoretina and Uvea, ICARE Eye Hospital & Postgraduate Institute, Noida, Uttar Pradesh, IndiaThe author read with interest the article by Browning et al.1 The author humbly wants to discuss a few facts.1. The article1 discusses grading of retinal ischemia based on optical coherence tomography features in central retinal venous occlusion. As coexisting central retinal arterial occlusion or cilioretinal arterial occlusion may also cause inner retinal hyper-reflectivity, exclusion of such cases is an important consideration before implicating central retinal venous occlusion for the ischemia. Extensive intraretinal hemorrhages are other important hindrances to the evaluation of the perfusion status of the retina using both fluorescein angiogram and optical coherence tomography.2. It would be interesting to know the gonioscopic findings, especially neovascularization of the anterior chamber angle if it was performed at presentation and during the follow-ups.3. The manuscript documented that the incidence of anterior segment neovascularization at 1 year was 8.9% in severe ischemia group.1 The incidence of anterior segment neovascularization in perfused groups was higher (15.4% and 17.6% for mild and moderate ischemia, respectively). Although the sample size was low, such findings are contrary to the literature2 and require further discussion. Authors' replyDavid J Browning, Omar S Punjabi, Chong LeeDepartment of Ophthalmology, Charlotte Eye, Ear, Nose and Throat Associates, P.A., Charlotte, NC, USA We thank Dr Tripathy for his interest in our article and would respond to his above-mentioned points.1. We agree that excluding eyes with cilioretinal artery and central retinal artery occlusions is necessary to be able to attribute inner retinal reflectivity changes to central retinal vein occlusion. Cilioretinal artery occlusion is associated with a band of ischemic retinal whitening and central retinal artery occlusion more generalized posterior-pole ischemic whitening. Neither was present in any of our patients. The changes in inner retinal reflectivity were present without visible whitening.The confounding effects of intraretinal hemorrhage were recognized and accounted for as found in the following sentence in “Methods” section: “When there was concomitant intraretinal hemorrhage, the grading was done based on a zone without intraretinal hemorrhage if one was present, but if intraretinal hemorrhage was confluent, the inner retina was hyperreflective and delineation of layers was obscured by the hemorrhage, such cases were graded as severe ischemia”.2. This was a retrospective study drawn from two retina specialists (DJB and OSP). There was no standardization about when gonioscopy was performed. Therefore, the development of anterior segment neovascularization (ASNV) may have been underestimated relative to a figure derived from a systematic prospective study in which gonioscopy would be uniformly performed before pupillary dilation.3. The incidence of ASNV recorded in Table 2 of the manuscript was confounded by the frequent injection of antivascular endothelial growth factor drugs for macular edema in all three groups. As we wrote in the “Discussion” section: “The frequent injection of anti-VEGF drugs not only treated the macular edema but also probably masked any underlying associations of ASNV and NVG with baseline ischemia”.View the original paper by Browning et al.Tripathy KDove Medical PressarticleOCTcentral retinal artery occlusionneovascularization of irisneovascularization of the anterior chamber angleOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 409-410 (2017)

Regarding optical coherence tomography grading of ischemia in central retinal venous occlusion

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