AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination
Invasion of malignant cells involves changes in cytoskeleton dynamics. Here the authors identify absent in melanoma 1 as an actin binding protein and show that it regulates cytoskeletal remodeling and cell migration in prostate epithelial cells, acting as a metastatic suppressor in cancer cells.
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Nature Portfolio
2017
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oai:doaj.org-article:41b0a231505343d098eefebb391e055f2021-12-02T13:57:33ZAIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination10.1038/s41467-017-00084-82041-1723https://doaj.org/article/41b0a231505343d098eefebb391e055f2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00084-8https://doaj.org/toc/2041-1723Invasion of malignant cells involves changes in cytoskeleton dynamics. Here the authors identify absent in melanoma 1 as an actin binding protein and show that it regulates cytoskeletal remodeling and cell migration in prostate epithelial cells, acting as a metastatic suppressor in cancer cells.Michael C. HaffnerDavid M. EsopiAlcides ChauxMeltem GürelSusmita GhoshAjay M. VaghasiaHarrison TsaiKunhwa KimNicole CastagnaHong LamJessica HicksNicolas WyhsDebika Biswal ShinoharaPaula J. HurleyBrian W. SimonsEdward M. SchaefferTamara L. LotanWilliam B. IsaacsGeorge J. NettoAngelo M. De MarzoWilliam G. NelsonSteven S. AnSrinivasan YegnasubramanianNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Michael C. Haffner David M. Esopi Alcides Chaux Meltem Gürel Susmita Ghosh Ajay M. Vaghasia Harrison Tsai Kunhwa Kim Nicole Castagna Hong Lam Jessica Hicks Nicolas Wyhs Debika Biswal Shinohara Paula J. Hurley Brian W. Simons Edward M. Schaeffer Tamara L. Lotan William B. Isaacs George J. Netto Angelo M. De Marzo William G. Nelson Steven S. An Srinivasan Yegnasubramanian AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination |
| description |
Invasion of malignant cells involves changes in cytoskeleton dynamics. Here the authors identify absent in melanoma 1 as an actin binding protein and show that it regulates cytoskeletal remodeling and cell migration in prostate epithelial cells, acting as a metastatic suppressor in cancer cells. |
| format |
article |
| author |
Michael C. Haffner David M. Esopi Alcides Chaux Meltem Gürel Susmita Ghosh Ajay M. Vaghasia Harrison Tsai Kunhwa Kim Nicole Castagna Hong Lam Jessica Hicks Nicolas Wyhs Debika Biswal Shinohara Paula J. Hurley Brian W. Simons Edward M. Schaeffer Tamara L. Lotan William B. Isaacs George J. Netto Angelo M. De Marzo William G. Nelson Steven S. An Srinivasan Yegnasubramanian |
| author_facet |
Michael C. Haffner David M. Esopi Alcides Chaux Meltem Gürel Susmita Ghosh Ajay M. Vaghasia Harrison Tsai Kunhwa Kim Nicole Castagna Hong Lam Jessica Hicks Nicolas Wyhs Debika Biswal Shinohara Paula J. Hurley Brian W. Simons Edward M. Schaeffer Tamara L. Lotan William B. Isaacs George J. Netto Angelo M. De Marzo William G. Nelson Steven S. An Srinivasan Yegnasubramanian |
| author_sort |
Michael C. Haffner |
| title |
AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination |
| title_short |
AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination |
| title_full |
AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination |
| title_fullStr |
AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination |
| title_full_unstemmed |
AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination |
| title_sort |
aim1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/41b0a231505343d098eefebb391e055f |
| work_keys_str_mv |
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