Evidence for altered neurodevelopment and neurodegeneration in Wolfram syndrome using longitudinal morphometry

Abstract Wolfram syndrome is a rare disease caused by mutations in the WFS1 gene leading to symptoms in early to mid-childhood. Brain structural abnormalities are present even in young children, but it is not known when these abnormalities arise. Such information is critical in determining optimal o...

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Autores principales: Heather M. Lugar, Jonathan M. Koller, Jerrel Rutlin, Sarah A. Eisenstein, Olga Neyman, Anagha Narayanan, Ling Chen, Joshua S. Shimony, Tamara Hershey
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/41b133a9020c497c8b1dc5bf0c1d1452
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