A High-Sodium Diet Modulates the Immune Response of Food Allergy in a Murine Model

Mounting evidence demonstrates that a high-salt diet (HSD) not only affects hemodynamic changes but also disrupts immune homeostasis. The T helper 17 (Th17) and regulatory T cells (Tregs) are susceptible to hypersalinity. However, research on the influence of sodium on Th2-mediated food allergies re...

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Autores principales:	Zheying Liu, Shih-Kuan Li, Chih-Kang Huang, Ching-Feng Huang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	food allergy ovalbumin IgE high salt diet Th2 response Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/41b26e17205c4b3192bcaf95cfabbda7
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spelling	oai:doaj.org-article:41b26e17205c4b3192bcaf95cfabbda72021-11-25T18:33:10ZA High-Sodium Diet Modulates the Immune Response of Food Allergy in a Murine Model10.3390/nu131136842072-6643https://doaj.org/article/41b26e17205c4b3192bcaf95cfabbda72021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3684https://doaj.org/toc/2072-6643Mounting evidence demonstrates that a high-salt diet (HSD) not only affects hemodynamic changes but also disrupts immune homeostasis. The T helper 17 (Th17) and regulatory T cells (Tregs) are susceptible to hypersalinity. However, research on the influence of sodium on Th2-mediated food allergies remains scarce. We aimed to investigate the effect of dietary sodium on the immune response to food allergies. Mice maintained on an HSD (4% NaCl), low-salt diet (LSD; 0.4% NaCl), or control diet (CTRL; 1.0% NaCl) were orally sensitized with ovalbumin (OVA) and a cholera toxin (CT) adjuvant, and then subjected to an intragastric OVA challenge. OVA-specific immunoglobulin G (IgG), IgG1, IgG2a, and IgE antibodies were significantly higher in the HSD group than in the CTRL group (<i>p <</i> 0.001, <i>p</i> < 0.05, <i>p</i> < 0.01, and <i>p</i> < 0.05, respectively). Mice on HSD had significantly higher interleukin (IL)-4 levels than the CTRL group (<i>p</i> < 0.01). The IL-10 levels were significantly lower in the HSD group than in the CTRL group (<i>p</i> < 0.05). The serum levels of interferon-γ (IFN-γ), sodium, and chloride did not differ among the three groups. This study indicates that excessive salt intake promotes Th2 responses in a mouse model of food allergy.Zheying LiuShih-Kuan LiChih-Kang HuangChing-Feng HuangMDPI AGarticlefood allergyovalbuminIgEhigh salt dietTh2 responseNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3684, p 3684 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	food allergy ovalbumin IgE high salt diet Th2 response Nutrition. Foods and food supply TX341-641
spellingShingle	food allergy ovalbumin IgE high salt diet Th2 response Nutrition. Foods and food supply TX341-641 Zheying Liu Shih-Kuan Li Chih-Kang Huang Ching-Feng Huang A High-Sodium Diet Modulates the Immune Response of Food Allergy in a Murine Model
description	Mounting evidence demonstrates that a high-salt diet (HSD) not only affects hemodynamic changes but also disrupts immune homeostasis. The T helper 17 (Th17) and regulatory T cells (Tregs) are susceptible to hypersalinity. However, research on the influence of sodium on Th2-mediated food allergies remains scarce. We aimed to investigate the effect of dietary sodium on the immune response to food allergies. Mice maintained on an HSD (4% NaCl), low-salt diet (LSD; 0.4% NaCl), or control diet (CTRL; 1.0% NaCl) were orally sensitized with ovalbumin (OVA) and a cholera toxin (CT) adjuvant, and then subjected to an intragastric OVA challenge. OVA-specific immunoglobulin G (IgG), IgG1, IgG2a, and IgE antibodies were significantly higher in the HSD group than in the CTRL group (<i>p <</i> 0.001, <i>p</i> < 0.05, <i>p</i> < 0.01, and <i>p</i> < 0.05, respectively). Mice on HSD had significantly higher interleukin (IL)-4 levels than the CTRL group (<i>p</i> < 0.01). The IL-10 levels were significantly lower in the HSD group than in the CTRL group (<i>p</i> < 0.05). The serum levels of interferon-γ (IFN-γ), sodium, and chloride did not differ among the three groups. This study indicates that excessive salt intake promotes Th2 responses in a mouse model of food allergy.
format	article
author	Zheying Liu Shih-Kuan Li Chih-Kang Huang Ching-Feng Huang
author_facet	Zheying Liu Shih-Kuan Li Chih-Kang Huang Ching-Feng Huang
author_sort	Zheying Liu
title	A High-Sodium Diet Modulates the Immune Response of Food Allergy in a Murine Model
title_short	A High-Sodium Diet Modulates the Immune Response of Food Allergy in a Murine Model
title_full	A High-Sodium Diet Modulates the Immune Response of Food Allergy in a Murine Model
title_fullStr	A High-Sodium Diet Modulates the Immune Response of Food Allergy in a Murine Model
title_full_unstemmed	A High-Sodium Diet Modulates the Immune Response of Food Allergy in a Murine Model
title_sort	high-sodium diet modulates the immune response of food allergy in a murine model
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/41b26e17205c4b3192bcaf95cfabbda7
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A High-Sodium Diet Modulates the Immune Response of Food Allergy in a Murine Model

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