Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy

Inhibition of PERK, an endoplasmic reticulum (ER) unfolded protein response (UPR) protein, is a potential pharmacological target for cancer treatment. Here, the authors show that inhibition of PERK under ER stress affects trafficking from the ER to the surface of several key receptor tyrosine kinase...

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Main Authors:	Mohamed Mahameed, Shatha Boukeileh, Akram Obiedat, Odai Darawshi, Priya Dipta, Amit Rimon, Gordon McLennan, Rosi Fassler, Dana Reichmann, Rotem Karni, Christian Preisinger, Thomas Wilhelm, Michael Huber, Boaz Tirosh
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/41b3dd4a0c9748dc8d4f1d07443c6ee2
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id	oai:doaj.org-article:41b3dd4a0c9748dc8d4f1d07443c6ee2
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spelling	oai:doaj.org-article:41b3dd4a0c9748dc8d4f1d07443c6ee22021-12-02T16:56:49ZPharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy10.1038/s41467-020-15067-52041-1723https://doaj.org/article/41b3dd4a0c9748dc8d4f1d07443c6ee22020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15067-5https://doaj.org/toc/2041-1723Inhibition of PERK, an endoplasmic reticulum (ER) unfolded protein response (UPR) protein, is a potential pharmacological target for cancer treatment. Here, the authors show that inhibition of PERK under ER stress affects trafficking from the ER to the surface of several key receptor tyrosine kinases, suggesting a selective ER retention.Mohamed MahameedShatha BoukeilehAkram ObiedatOdai DarawshiPriya DiptaAmit RimonGordon McLennanRosi FasslerDana ReichmannRotem KarniChristian PreisingerThomas WilhelmMichael HuberBoaz TiroshNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mohamed Mahameed Shatha Boukeileh Akram Obiedat Odai Darawshi Priya Dipta Amit Rimon Gordon McLennan Rosi Fassler Dana Reichmann Rotem Karni Christian Preisinger Thomas Wilhelm Michael Huber Boaz Tirosh Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy
description	Inhibition of PERK, an endoplasmic reticulum (ER) unfolded protein response (UPR) protein, is a potential pharmacological target for cancer treatment. Here, the authors show that inhibition of PERK under ER stress affects trafficking from the ER to the surface of several key receptor tyrosine kinases, suggesting a selective ER retention.
format	article
author	Mohamed Mahameed Shatha Boukeileh Akram Obiedat Odai Darawshi Priya Dipta Amit Rimon Gordon McLennan Rosi Fassler Dana Reichmann Rotem Karni Christian Preisinger Thomas Wilhelm Michael Huber Boaz Tirosh
author_facet	Mohamed Mahameed Shatha Boukeileh Akram Obiedat Odai Darawshi Priya Dipta Amit Rimon Gordon McLennan Rosi Fassler Dana Reichmann Rotem Karni Christian Preisinger Thomas Wilhelm Michael Huber Boaz Tirosh
author_sort	Mohamed Mahameed
title	Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy
title_short	Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy
title_full	Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy
title_fullStr	Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy
title_full_unstemmed	Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy
title_sort	pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/41b3dd4a0c9748dc8d4f1d07443c6ee2
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Pharmacological induction of selective endoplasmic reticulum retention as a strategy for cancer therapy

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