Thermosensitive liposomal drug delivery systems: state of the art review

Barbara Kneidl,1,2 Michael Peller,3 Gerhard Winter,2 Lars H Lindner,1 Martin Hossann11Department of Internal Medicine III, University Hospital Munich, 2Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, 3Institute for Clinical Radiology, University Hospital Munich, Ludwig-Maxim...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Kneidl B, Peller M, Winter G, Lindner LH, Hossann M
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://doaj.org/article/41b99938a1d74bf28d0ae0a000a01a2a
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:41b99938a1d74bf28d0ae0a000a01a2a
record_format dspace
spelling oai:doaj.org-article:41b99938a1d74bf28d0ae0a000a01a2a2021-12-02T02:32:06ZThermosensitive liposomal drug delivery systems: state of the art review1178-2013https://doaj.org/article/41b99938a1d74bf28d0ae0a000a01a2a2014-09-01T00:00:00Zhttp://www.dovepress.com/thermosensitive-liposomal-drug-delivery-systems-state-of-the-art-revie-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Barbara Kneidl,1,2 Michael Peller,3 Gerhard Winter,2 Lars H Lindner,1 Martin Hossann11Department of Internal Medicine III, University Hospital Munich, 2Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, 3Institute for Clinical Radiology, University Hospital Munich, Ludwig-Maximilians University, Munich, GermanyAbstract: Thermosensitive liposomes are a promising tool for external targeting of drugs to solid tumors when used in combination with local hyperthermia or high intensity focused ultrasound. In vivo results have demonstrated strong evidence that external targeting is superior over passive targeting achieved by highly stable long-circulating drug formulations like PEGylated liposomal doxorubicin. Up to March 2014, the Web of Science listed 371 original papers in this field, with 45 in 2013 alone. Several formulations have been developed since 1978, with lysolipid-containing, low temperature-sensitive liposomes currently under clinical investigation. This review summarizes the historical development and effects of particular phospholipids and surfactants on the biophysical properties and in vivo efficacy of thermosensitive liposome formulations. Further, treatment strategies for solid tumors are discussed. Here we focus on temperature-triggered intravascular and interstitial drug release. Drug delivery guided by magnetic resonance imaging further adds the possibility of performing online monitoring of a heating focus to calculate locally released drug concentrations and to externally control drug release by steering the heating volume and power. The combination of external targeting with thermosensitive liposomes and magnetic resonance-guided drug delivery will be the unique characteristic of this nanotechnology approach in medicine.Keywords: thermosensitive liposomes, phosphatidyloligoglycerol, hyperthermia, high intensity focused ultrasound, drug delivery, drug targetingKneidl BPeller MWinter GLindner LHHossann MDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 4387-4398 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Kneidl B
Peller M
Winter G
Lindner LH
Hossann M
Thermosensitive liposomal drug delivery systems: state of the art review
description Barbara Kneidl,1,2 Michael Peller,3 Gerhard Winter,2 Lars H Lindner,1 Martin Hossann11Department of Internal Medicine III, University Hospital Munich, 2Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, 3Institute for Clinical Radiology, University Hospital Munich, Ludwig-Maximilians University, Munich, GermanyAbstract: Thermosensitive liposomes are a promising tool for external targeting of drugs to solid tumors when used in combination with local hyperthermia or high intensity focused ultrasound. In vivo results have demonstrated strong evidence that external targeting is superior over passive targeting achieved by highly stable long-circulating drug formulations like PEGylated liposomal doxorubicin. Up to March 2014, the Web of Science listed 371 original papers in this field, with 45 in 2013 alone. Several formulations have been developed since 1978, with lysolipid-containing, low temperature-sensitive liposomes currently under clinical investigation. This review summarizes the historical development and effects of particular phospholipids and surfactants on the biophysical properties and in vivo efficacy of thermosensitive liposome formulations. Further, treatment strategies for solid tumors are discussed. Here we focus on temperature-triggered intravascular and interstitial drug release. Drug delivery guided by magnetic resonance imaging further adds the possibility of performing online monitoring of a heating focus to calculate locally released drug concentrations and to externally control drug release by steering the heating volume and power. The combination of external targeting with thermosensitive liposomes and magnetic resonance-guided drug delivery will be the unique characteristic of this nanotechnology approach in medicine.Keywords: thermosensitive liposomes, phosphatidyloligoglycerol, hyperthermia, high intensity focused ultrasound, drug delivery, drug targeting
format article
author Kneidl B
Peller M
Winter G
Lindner LH
Hossann M
author_facet Kneidl B
Peller M
Winter G
Lindner LH
Hossann M
author_sort Kneidl B
title Thermosensitive liposomal drug delivery systems: state of the art review
title_short Thermosensitive liposomal drug delivery systems: state of the art review
title_full Thermosensitive liposomal drug delivery systems: state of the art review
title_fullStr Thermosensitive liposomal drug delivery systems: state of the art review
title_full_unstemmed Thermosensitive liposomal drug delivery systems: state of the art review
title_sort thermosensitive liposomal drug delivery systems: state of the art review
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/41b99938a1d74bf28d0ae0a000a01a2a
work_keys_str_mv AT kneidlb thermosensitiveliposomaldrugdeliverysystemsstateoftheartreview
AT pellerm thermosensitiveliposomaldrugdeliverysystemsstateoftheartreview
AT winterg thermosensitiveliposomaldrugdeliverysystemsstateoftheartreview
AT lindnerlh thermosensitiveliposomaldrugdeliverysystemsstateoftheartreview
AT hossannm thermosensitiveliposomaldrugdeliverysystemsstateoftheartreview
_version_ 1718402403387047936