Corticoreticular Pathway in Post-Stroke Spasticity: A Diffusion Tensor Imaging Study

One of the pathophysiologies of post-stroke spasticity (PSS) is the imbalance of the reticulospinal tract (RST) caused by injury to the corticoreticular pathway (CRP) after stroke. We investigated the relationship between injuries of the CRP and PSS using MR diffusion tensor imaging (DTI). The subje...

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Autores principales:	Sung-Hwa Ko, Taehyung Kim, Ji Hong Min, Musu Kim, Hyun-Yoon Ko, Yong-Il Shin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	corticoreticular pathway diffusion tensor imaging reticulospinal tract spasticity stroke Medicine R
Acceso en línea:	https://doaj.org/article/41bacb0f3bc147dda6e406cad4456b9b
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spelling	oai:doaj.org-article:41bacb0f3bc147dda6e406cad4456b9b2021-11-25T18:07:35ZCorticoreticular Pathway in Post-Stroke Spasticity: A Diffusion Tensor Imaging Study10.3390/jpm111111512075-4426https://doaj.org/article/41bacb0f3bc147dda6e406cad4456b9b2021-11-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1151https://doaj.org/toc/2075-4426One of the pathophysiologies of post-stroke spasticity (PSS) is the imbalance of the reticulospinal tract (RST) caused by injury to the corticoreticular pathway (CRP) after stroke. We investigated the relationship between injuries of the CRP and PSS using MR diffusion tensor imaging (DTI). The subjects were divided into spasticity and control groups. We measured the ipsilesional fractional anisotropy (iFA) and contralesional fractional anisotropy (cFA) values on the reticular formation (RF) of the CRP were on the DTI images. We carried out a retrospective analysis of 70 patients with ischemic stroke. The cFA values of CRP in the spasticity group were lower than those in the control group (<i>p</i> = 0.04). In the sub-ROI analysis of CRP, the iFA values of pontine RF were lower than the cFA values in both groups (<i>p</i> < 0.05). The cFA values of medullary RF in the spasticity group were lower than the iFA values within groups, and also lower than the cFA values in the control group (<i>p</i> < 0.05). This results showed the CRP injury and that imbalance of RST caused by CRP injury was associated with PSS. DTI analysis of CRP could provide imaging evidence for the pathophysiology of PSS.Sung-Hwa KoTaehyung KimJi Hong MinMusu KimHyun-Yoon KoYong-Il ShinMDPI AGarticlecorticoreticular pathwaydiffusion tensor imagingreticulospinal tractspasticitystrokeMedicineRENJournal of Personalized Medicine, Vol 11, Iss 1151, p 1151 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	corticoreticular pathway diffusion tensor imaging reticulospinal tract spasticity stroke Medicine R
spellingShingle	corticoreticular pathway diffusion tensor imaging reticulospinal tract spasticity stroke Medicine R Sung-Hwa Ko Taehyung Kim Ji Hong Min Musu Kim Hyun-Yoon Ko Yong-Il Shin Corticoreticular Pathway in Post-Stroke Spasticity: A Diffusion Tensor Imaging Study
description	One of the pathophysiologies of post-stroke spasticity (PSS) is the imbalance of the reticulospinal tract (RST) caused by injury to the corticoreticular pathway (CRP) after stroke. We investigated the relationship between injuries of the CRP and PSS using MR diffusion tensor imaging (DTI). The subjects were divided into spasticity and control groups. We measured the ipsilesional fractional anisotropy (iFA) and contralesional fractional anisotropy (cFA) values on the reticular formation (RF) of the CRP were on the DTI images. We carried out a retrospective analysis of 70 patients with ischemic stroke. The cFA values of CRP in the spasticity group were lower than those in the control group (<i>p</i> = 0.04). In the sub-ROI analysis of CRP, the iFA values of pontine RF were lower than the cFA values in both groups (<i>p</i> < 0.05). The cFA values of medullary RF in the spasticity group were lower than the iFA values within groups, and also lower than the cFA values in the control group (<i>p</i> < 0.05). This results showed the CRP injury and that imbalance of RST caused by CRP injury was associated with PSS. DTI analysis of CRP could provide imaging evidence for the pathophysiology of PSS.
format	article
author	Sung-Hwa Ko Taehyung Kim Ji Hong Min Musu Kim Hyun-Yoon Ko Yong-Il Shin
author_facet	Sung-Hwa Ko Taehyung Kim Ji Hong Min Musu Kim Hyun-Yoon Ko Yong-Il Shin
author_sort	Sung-Hwa Ko
title	Corticoreticular Pathway in Post-Stroke Spasticity: A Diffusion Tensor Imaging Study
title_short	Corticoreticular Pathway in Post-Stroke Spasticity: A Diffusion Tensor Imaging Study
title_full	Corticoreticular Pathway in Post-Stroke Spasticity: A Diffusion Tensor Imaging Study
title_fullStr	Corticoreticular Pathway in Post-Stroke Spasticity: A Diffusion Tensor Imaging Study
title_full_unstemmed	Corticoreticular Pathway in Post-Stroke Spasticity: A Diffusion Tensor Imaging Study
title_sort	corticoreticular pathway in post-stroke spasticity: a diffusion tensor imaging study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/41bacb0f3bc147dda6e406cad4456b9b
work_keys_str_mv	AT sunghwako corticoreticularpathwayinpoststrokespasticityadiffusiontensorimagingstudy AT taehyungkim corticoreticularpathwayinpoststrokespasticityadiffusiontensorimagingstudy AT jihongmin corticoreticularpathwayinpoststrokespasticityadiffusiontensorimagingstudy AT musukim corticoreticularpathwayinpoststrokespasticityadiffusiontensorimagingstudy AT hyunyoonko corticoreticularpathwayinpoststrokespasticityadiffusiontensorimagingstudy AT yongilshin corticoreticularpathwayinpoststrokespasticityadiffusiontensorimagingstudy
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Corticoreticular Pathway in Post-Stroke Spasticity: A Diffusion Tensor Imaging Study

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