Kindlin-2 links mechano-environment to proline synthesis and tumor growth

The mechano-properties of the Extracellular Matrix (ECM) are important for tumorigenesis. Here, the authors show that the stiffening of the ECM promotes translocation of the focal adhesion protein—Kindlin-2—to the mitochondria, where it interacts with the proline synthesis enzyme PYCR1, stimulating...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ling Guo, Chunhong Cui, Kuo Zhang, Jiaxin Wang, Yilin Wang, Yixuan Lu, Ka Chen, Jifan Yuan, Guozhi Xiao, Bin Tang, Ying Sun, Chuanyue Wu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/41baf5a45eef4a66bff8a2e90d14d799
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:41baf5a45eef4a66bff8a2e90d14d799
record_format	dspace
spelling	oai:doaj.org-article:41baf5a45eef4a66bff8a2e90d14d7992021-12-02T16:57:10ZKindlin-2 links mechano-environment to proline synthesis and tumor growth10.1038/s41467-019-08772-32041-1723https://doaj.org/article/41baf5a45eef4a66bff8a2e90d14d7992019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08772-3https://doaj.org/toc/2041-1723The mechano-properties of the Extracellular Matrix (ECM) are important for tumorigenesis. Here, the authors show that the stiffening of the ECM promotes translocation of the focal adhesion protein—Kindlin-2—to the mitochondria, where it interacts with the proline synthesis enzyme PYCR1, stimulating proline synthesis and cell proliferation.Ling GuoChunhong CuiKuo ZhangJiaxin WangYilin WangYixuan LuKa ChenJifan YuanGuozhi XiaoBin TangYing SunChuanyue WuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ling Guo Chunhong Cui Kuo Zhang Jiaxin Wang Yilin Wang Yixuan Lu Ka Chen Jifan Yuan Guozhi Xiao Bin Tang Ying Sun Chuanyue Wu Kindlin-2 links mechano-environment to proline synthesis and tumor growth
description	The mechano-properties of the Extracellular Matrix (ECM) are important for tumorigenesis. Here, the authors show that the stiffening of the ECM promotes translocation of the focal adhesion protein—Kindlin-2—to the mitochondria, where it interacts with the proline synthesis enzyme PYCR1, stimulating proline synthesis and cell proliferation.
format	article
author	Ling Guo Chunhong Cui Kuo Zhang Jiaxin Wang Yilin Wang Yixuan Lu Ka Chen Jifan Yuan Guozhi Xiao Bin Tang Ying Sun Chuanyue Wu
author_facet	Ling Guo Chunhong Cui Kuo Zhang Jiaxin Wang Yilin Wang Yixuan Lu Ka Chen Jifan Yuan Guozhi Xiao Bin Tang Ying Sun Chuanyue Wu
author_sort	Ling Guo
title	Kindlin-2 links mechano-environment to proline synthesis and tumor growth
title_short	Kindlin-2 links mechano-environment to proline synthesis and tumor growth
title_full	Kindlin-2 links mechano-environment to proline synthesis and tumor growth
title_fullStr	Kindlin-2 links mechano-environment to proline synthesis and tumor growth
title_full_unstemmed	Kindlin-2 links mechano-environment to proline synthesis and tumor growth
title_sort	kindlin-2 links mechano-environment to proline synthesis and tumor growth
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/41baf5a45eef4a66bff8a2e90d14d799
work_keys_str_mv	AT lingguo kindlin2linksmechanoenvironmenttoprolinesynthesisandtumorgrowth AT chunhongcui kindlin2linksmechanoenvironmenttoprolinesynthesisandtumorgrowth AT kuozhang kindlin2linksmechanoenvironmenttoprolinesynthesisandtumorgrowth AT jiaxinwang kindlin2linksmechanoenvironmenttoprolinesynthesisandtumorgrowth AT yilinwang kindlin2linksmechanoenvironmenttoprolinesynthesisandtumorgrowth AT yixuanlu kindlin2linksmechanoenvironmenttoprolinesynthesisandtumorgrowth AT kachen kindlin2linksmechanoenvironmenttoprolinesynthesisandtumorgrowth AT jifanyuan kindlin2linksmechanoenvironmenttoprolinesynthesisandtumorgrowth AT guozhixiao kindlin2linksmechanoenvironmenttoprolinesynthesisandtumorgrowth AT bintang kindlin2linksmechanoenvironmenttoprolinesynthesisandtumorgrowth AT yingsun kindlin2linksmechanoenvironmenttoprolinesynthesisandtumorgrowth AT chuanyuewu kindlin2linksmechanoenvironmenttoprolinesynthesisandtumorgrowth
_version_	1718382620111273984

Kindlin-2 links mechano-environment to proline synthesis and tumor growth

Ejemplares similares