Muscle transcriptome provides the first insight into the dynamics of gene expression with progression of age in sheep

Abstract The dynamic synergy of genes and pathways in muscles in relation to age affects the muscle characteristics. Investigating the temporal changes in gene expression will help illustrate the molecular mechanisms underlying muscle development. Here we report the gene expression changes in skelet...

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Autores principales:	Reena Arora, Naveen Kumar Siddaraju, S. S. Manjunatha, S. Sudarshan, Mohamed Nadeem Fairoze, Ashish Kumar, Pooja Chhabra, Mandeep Kaur, R. M. Sreesujatha, Sonika Ahlawat, Ramesh Kumar Vijh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/41bb39f10afb4bdda21bdfaa31cacf32
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spelling	oai:doaj.org-article:41bb39f10afb4bdda21bdfaa31cacf322021-11-21T12:24:19ZMuscle transcriptome provides the first insight into the dynamics of gene expression with progression of age in sheep10.1038/s41598-021-01848-52045-2322https://doaj.org/article/41bb39f10afb4bdda21bdfaa31cacf322021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01848-5https://doaj.org/toc/2045-2322Abstract The dynamic synergy of genes and pathways in muscles in relation to age affects the muscle characteristics. Investigating the temporal changes in gene expression will help illustrate the molecular mechanisms underlying muscle development. Here we report the gene expression changes in skeletal muscles through successive age groups in Bandur, a meat type sheep of India. RNA sequencing data was generated from the longissimus thoracis muscles from four age groups, ranging from lamb to adult. Analysis of 20 highest expressed genes common across the groups revealed muscle protein, phosphorylation, acetylation, metal binding and transport as significant functions. Maximum differentiation was observed after 2.5–3 years on transition from lambs to adult. Transcriptional regulation by the TFAP2 transcription factors, IL-6 signaling and PI3K/AKT signaling pathways were enriched in younger animals. The gene-protein network demarcated key interactive genes involved in muscle development and proliferation that can be used as candidates for future research on improvement of muscle characteristics.Reena AroraNaveen Kumar SiddarajuS. S. ManjunathaS. SudarshanMohamed Nadeem FairozeAshish KumarPooja ChhabraMandeep KaurR. M. SreesujathaSonika AhlawatRamesh Kumar VijhNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Reena Arora Naveen Kumar Siddaraju S. S. Manjunatha S. Sudarshan Mohamed Nadeem Fairoze Ashish Kumar Pooja Chhabra Mandeep Kaur R. M. Sreesujatha Sonika Ahlawat Ramesh Kumar Vijh Muscle transcriptome provides the first insight into the dynamics of gene expression with progression of age in sheep
description	Abstract The dynamic synergy of genes and pathways in muscles in relation to age affects the muscle characteristics. Investigating the temporal changes in gene expression will help illustrate the molecular mechanisms underlying muscle development. Here we report the gene expression changes in skeletal muscles through successive age groups in Bandur, a meat type sheep of India. RNA sequencing data was generated from the longissimus thoracis muscles from four age groups, ranging from lamb to adult. Analysis of 20 highest expressed genes common across the groups revealed muscle protein, phosphorylation, acetylation, metal binding and transport as significant functions. Maximum differentiation was observed after 2.5–3 years on transition from lambs to adult. Transcriptional regulation by the TFAP2 transcription factors, IL-6 signaling and PI3K/AKT signaling pathways were enriched in younger animals. The gene-protein network demarcated key interactive genes involved in muscle development and proliferation that can be used as candidates for future research on improvement of muscle characteristics.
format	article
author	Reena Arora Naveen Kumar Siddaraju S. S. Manjunatha S. Sudarshan Mohamed Nadeem Fairoze Ashish Kumar Pooja Chhabra Mandeep Kaur R. M. Sreesujatha Sonika Ahlawat Ramesh Kumar Vijh
author_facet	Reena Arora Naveen Kumar Siddaraju S. S. Manjunatha S. Sudarshan Mohamed Nadeem Fairoze Ashish Kumar Pooja Chhabra Mandeep Kaur R. M. Sreesujatha Sonika Ahlawat Ramesh Kumar Vijh
author_sort	Reena Arora
title	Muscle transcriptome provides the first insight into the dynamics of gene expression with progression of age in sheep
title_short	Muscle transcriptome provides the first insight into the dynamics of gene expression with progression of age in sheep
title_full	Muscle transcriptome provides the first insight into the dynamics of gene expression with progression of age in sheep
title_fullStr	Muscle transcriptome provides the first insight into the dynamics of gene expression with progression of age in sheep
title_full_unstemmed	Muscle transcriptome provides the first insight into the dynamics of gene expression with progression of age in sheep
title_sort	muscle transcriptome provides the first insight into the dynamics of gene expression with progression of age in sheep
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/41bb39f10afb4bdda21bdfaa31cacf32
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Muscle transcriptome provides the first insight into the dynamics of gene expression with progression of age in sheep

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