The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche

Colony stimulating factor 1 controls the growth and differentiation of macrophages. Here the authors demonstrate that its blockade depletes gut macrophages and indirectly affects gut epithelial cell differentiation as the macrophages help maintain the Paneth and stem cells in intestinal crypts.

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Autores principales:	Anuj Sehgal, David S. Donaldson, Clare Pridans, Kristin A. Sauter, David A. Hume, Neil A. Mabbott
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/41bc84cccb2a41ddac0bd4462faf311d
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spelling	oai:doaj.org-article:41bc84cccb2a41ddac0bd4462faf311d2021-12-02T14:39:22ZThe role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche10.1038/s41467-018-03638-62041-1723https://doaj.org/article/41bc84cccb2a41ddac0bd4462faf311d2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03638-6https://doaj.org/toc/2041-1723Colony stimulating factor 1 controls the growth and differentiation of macrophages. Here the authors demonstrate that its blockade depletes gut macrophages and indirectly affects gut epithelial cell differentiation as the macrophages help maintain the Paneth and stem cells in intestinal crypts.Anuj SehgalDavid S. DonaldsonClare PridansKristin A. SauterDavid A. HumeNeil A. MabbottNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anuj Sehgal David S. Donaldson Clare Pridans Kristin A. Sauter David A. Hume Neil A. Mabbott The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche
description	Colony stimulating factor 1 controls the growth and differentiation of macrophages. Here the authors demonstrate that its blockade depletes gut macrophages and indirectly affects gut epithelial cell differentiation as the macrophages help maintain the Paneth and stem cells in intestinal crypts.
format	article
author	Anuj Sehgal David S. Donaldson Clare Pridans Kristin A. Sauter David A. Hume Neil A. Mabbott
author_facet	Anuj Sehgal David S. Donaldson Clare Pridans Kristin A. Sauter David A. Hume Neil A. Mabbott
author_sort	Anuj Sehgal
title	The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche
title_short	The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche
title_full	The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche
title_fullStr	The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche
title_full_unstemmed	The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche
title_sort	role of csf1r-dependent macrophages in control of the intestinal stem-cell niche
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/41bc84cccb2a41ddac0bd4462faf311d
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The role of CSF1R-dependent macrophages in control of the intestinal stem-cell niche

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