Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response
IRE1α plays a key role in the unfolded protein response (UPR) by promoting the unconventional splicing of the XBP1 and the selective cleavage of RNAs. Here the authors report that IRE1α is activated upon the DNA damage response and selectively controls the stability of mRNAs to maintain genome integ...
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2020
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oai:doaj.org-article:41bd77e35d0d4d3fba7541fc5ffc64122021-12-02T15:54:44ZGenotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response10.1038/s41467-020-15694-y2041-1723https://doaj.org/article/41bd77e35d0d4d3fba7541fc5ffc64122020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15694-yhttps://doaj.org/toc/2041-1723IRE1α plays a key role in the unfolded protein response (UPR) by promoting the unconventional splicing of the XBP1 and the selective cleavage of RNAs. Here the authors report that IRE1α is activated upon the DNA damage response and selectively controls the stability of mRNAs to maintain genome integrity.Estefanie DufeyJosé Manuel Bravo-San PedroCristian EggersMatías González-QuirozHery UrraAlfredo I. SagredoDenisse SepulvedaPhilippe PihánAmado Carreras-SuredaYounis HazariEduardo A. SagredoDaniela GutierrezCristian VallsAlexandra PapaioannouDiego Acosta-AlvearGisela CamposPedro M. DomingosRémy PedeuxEric ChevetAlejandra AlvarezPatricio GodoyPeter WalterAlvaro GlavicGuido KroemerClaudio HetzNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020) |
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Science Q Estefanie Dufey José Manuel Bravo-San Pedro Cristian Eggers Matías González-Quiroz Hery Urra Alfredo I. Sagredo Denisse Sepulveda Philippe Pihán Amado Carreras-Sureda Younis Hazari Eduardo A. Sagredo Daniela Gutierrez Cristian Valls Alexandra Papaioannou Diego Acosta-Alvear Gisela Campos Pedro M. Domingos Rémy Pedeux Eric Chevet Alejandra Alvarez Patricio Godoy Peter Walter Alvaro Glavic Guido Kroemer Claudio Hetz Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response |
| description |
IRE1α plays a key role in the unfolded protein response (UPR) by promoting the unconventional splicing of the XBP1 and the selective cleavage of RNAs. Here the authors report that IRE1α is activated upon the DNA damage response and selectively controls the stability of mRNAs to maintain genome integrity. |
| format |
article |
| author |
Estefanie Dufey José Manuel Bravo-San Pedro Cristian Eggers Matías González-Quiroz Hery Urra Alfredo I. Sagredo Denisse Sepulveda Philippe Pihán Amado Carreras-Sureda Younis Hazari Eduardo A. Sagredo Daniela Gutierrez Cristian Valls Alexandra Papaioannou Diego Acosta-Alvear Gisela Campos Pedro M. Domingos Rémy Pedeux Eric Chevet Alejandra Alvarez Patricio Godoy Peter Walter Alvaro Glavic Guido Kroemer Claudio Hetz |
| author_facet |
Estefanie Dufey José Manuel Bravo-San Pedro Cristian Eggers Matías González-Quiroz Hery Urra Alfredo I. Sagredo Denisse Sepulveda Philippe Pihán Amado Carreras-Sureda Younis Hazari Eduardo A. Sagredo Daniela Gutierrez Cristian Valls Alexandra Papaioannou Diego Acosta-Alvear Gisela Campos Pedro M. Domingos Rémy Pedeux Eric Chevet Alejandra Alvarez Patricio Godoy Peter Walter Alvaro Glavic Guido Kroemer Claudio Hetz |
| author_sort |
Estefanie Dufey |
| title |
Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response |
| title_short |
Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response |
| title_full |
Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response |
| title_fullStr |
Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response |
| title_full_unstemmed |
Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response |
| title_sort |
genotoxic stress triggers the activation of ire1α-dependent rna decay to modulate the dna damage response |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/41bd77e35d0d4d3fba7541fc5ffc6412 |
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