Craniofacial shape in patients with beta thalassaemia: a geometric morphometric analysis

Abstract The shape of the craniofacial complex of patients with beta thalassaemia was evaluated using geometric morphometrics on lateral cephalometric radiographs and was compared with matched controls. The beta thalassaemia group consisted of 40 patients (16 females, 24 males, mean age 33.4). Each...

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Autores principales:	Petros Roussos, Anastasia Mitsea, Demetrios Halazonetis, Iosif Sifakakis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/41c276c688c640a094553fa36a5cbfab
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spelling	oai:doaj.org-article:41c276c688c640a094553fa36a5cbfab2021-12-02T11:50:30ZCraniofacial shape in patients with beta thalassaemia: a geometric morphometric analysis10.1038/s41598-020-80234-z2045-2322https://doaj.org/article/41c276c688c640a094553fa36a5cbfab2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80234-zhttps://doaj.org/toc/2045-2322Abstract The shape of the craniofacial complex of patients with beta thalassaemia was evaluated using geometric morphometrics on lateral cephalometric radiographs and was compared with matched controls. The beta thalassaemia group consisted of 40 patients (16 females, 24 males, mean age 33.4). Each patient was matched by age and gender to two controls (32 females, 48 males, mean age 33.1). The 120 lateral cephalometric radiographs were digitized and traced with 15 curves, 10 landmarks and 117 sliding semi-landmarks. These landmarks were subjected to Procrustes superimposition and principal component analysis in order to describe shape variability of the cranial base, maxilla and mandible, as well as of the entire craniofacial complex for each sex. The first 4 principal components accounted for 50% of the total sample’s variability. The beta thalassaemia group was significantly different in overall shape to the control group for both sexes. Similar findings were noted for the maxilla, the mandible and the cranial base. The main differences were related to smaller mandibular body for the thalassaemia group, midface protrusion and decrease in posterior face height. The shape of the craniofacial complex in these patients is prone to be more convex and hyperdivergent.Petros RoussosAnastasia MitseaDemetrios HalazonetisIosif SifakakisNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Petros Roussos Anastasia Mitsea Demetrios Halazonetis Iosif Sifakakis Craniofacial shape in patients with beta thalassaemia: a geometric morphometric analysis
description	Abstract The shape of the craniofacial complex of patients with beta thalassaemia was evaluated using geometric morphometrics on lateral cephalometric radiographs and was compared with matched controls. The beta thalassaemia group consisted of 40 patients (16 females, 24 males, mean age 33.4). Each patient was matched by age and gender to two controls (32 females, 48 males, mean age 33.1). The 120 lateral cephalometric radiographs were digitized and traced with 15 curves, 10 landmarks and 117 sliding semi-landmarks. These landmarks were subjected to Procrustes superimposition and principal component analysis in order to describe shape variability of the cranial base, maxilla and mandible, as well as of the entire craniofacial complex for each sex. The first 4 principal components accounted for 50% of the total sample’s variability. The beta thalassaemia group was significantly different in overall shape to the control group for both sexes. Similar findings were noted for the maxilla, the mandible and the cranial base. The main differences were related to smaller mandibular body for the thalassaemia group, midface protrusion and decrease in posterior face height. The shape of the craniofacial complex in these patients is prone to be more convex and hyperdivergent.
format	article
author	Petros Roussos Anastasia Mitsea Demetrios Halazonetis Iosif Sifakakis
author_facet	Petros Roussos Anastasia Mitsea Demetrios Halazonetis Iosif Sifakakis
author_sort	Petros Roussos
title	Craniofacial shape in patients with beta thalassaemia: a geometric morphometric analysis
title_short	Craniofacial shape in patients with beta thalassaemia: a geometric morphometric analysis
title_full	Craniofacial shape in patients with beta thalassaemia: a geometric morphometric analysis
title_fullStr	Craniofacial shape in patients with beta thalassaemia: a geometric morphometric analysis
title_full_unstemmed	Craniofacial shape in patients with beta thalassaemia: a geometric morphometric analysis
title_sort	craniofacial shape in patients with beta thalassaemia: a geometric morphometric analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/41c276c688c640a094553fa36a5cbfab
work_keys_str_mv	AT petrosroussos craniofacialshapeinpatientswithbetathalassaemiaageometricmorphometricanalysis AT anastasiamitsea craniofacialshapeinpatientswithbetathalassaemiaageometricmorphometricanalysis AT demetrioshalazonetis craniofacialshapeinpatientswithbetathalassaemiaageometricmorphometricanalysis AT iosifsifakakis craniofacialshapeinpatientswithbetathalassaemiaageometricmorphometricanalysis
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Craniofacial shape in patients with beta thalassaemia: a geometric morphometric analysis

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