Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells

The phosphatase Shp-2 was implicated in NK cell education due to its reported association with inhibitory receptors, but its function in this context is unclear. Here the authors show that Shp-2 is not required for NK cell function, but is necessary for IL-15-induced metabolic burst and expansion.

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Autores principales:	Charlène Niogret, S. M. Shahjahan Miah, Giorgia Rota, Nicolas P. Fonta, Haiping Wang, Werner Held, Walter Birchmeier, Veronica Sexl, Wentian Yang, Eric Vivier, Ping-Chih Ho, Laurent Brossay, Greta Guarda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/41cf5051ab934c2b9282cb0fc85ec566
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spelling	oai:doaj.org-article:41cf5051ab934c2b9282cb0fc85ec5662021-12-02T15:35:47ZShp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells10.1038/s41467-019-09431-32041-1723https://doaj.org/article/41cf5051ab934c2b9282cb0fc85ec5662019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09431-3https://doaj.org/toc/2041-1723The phosphatase Shp-2 was implicated in NK cell education due to its reported association with inhibitory receptors, but its function in this context is unclear. Here the authors show that Shp-2 is not required for NK cell function, but is necessary for IL-15-induced metabolic burst and expansion.Charlène NiogretS. M. Shahjahan MiahGiorgia RotaNicolas P. FontaHaiping WangWerner HeldWalter BirchmeierVeronica SexlWentian YangEric VivierPing-Chih HoLaurent BrossayGreta GuardaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Charlène Niogret S. M. Shahjahan Miah Giorgia Rota Nicolas P. Fonta Haiping Wang Werner Held Walter Birchmeier Veronica Sexl Wentian Yang Eric Vivier Ping-Chih Ho Laurent Brossay Greta Guarda Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells
description	The phosphatase Shp-2 was implicated in NK cell education due to its reported association with inhibitory receptors, but its function in this context is unclear. Here the authors show that Shp-2 is not required for NK cell function, but is necessary for IL-15-induced metabolic burst and expansion.
format	article
author	Charlène Niogret S. M. Shahjahan Miah Giorgia Rota Nicolas P. Fonta Haiping Wang Werner Held Walter Birchmeier Veronica Sexl Wentian Yang Eric Vivier Ping-Chih Ho Laurent Brossay Greta Guarda
author_facet	Charlène Niogret S. M. Shahjahan Miah Giorgia Rota Nicolas P. Fonta Haiping Wang Werner Held Walter Birchmeier Veronica Sexl Wentian Yang Eric Vivier Ping-Chih Ho Laurent Brossay Greta Guarda
author_sort	Charlène Niogret
title	Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells
title_short	Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells
title_full	Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells
title_fullStr	Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells
title_full_unstemmed	Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells
title_sort	shp-2 is critical for erk and metabolic engagement downstream of il-15 receptor in nk cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/41cf5051ab934c2b9282cb0fc85ec566
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Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells

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