COMPARISON OF EFFICACY OF TOPICAL CALCIPOTRIENE PLUS BETAMETHASONE WITH CALCIPOTRIENE ALONE IN LOCALIZED VITILIGO

Objective: To evaluate the efficacy of topical calcipotriene in comparison with topical calcipotriene plus betamethasone dipropionate in the treatment of localized vitiligo. Study Design: Randomized controlled trial. Place and Duration of Study: Study was carried out at department of Dermatolo...

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Autores principales: Usman Riaz, Zafar Iqbal Shaikh, Anwar Ul Islam
Formato: article
Lenguaje:EN
Publicado: Army Medical College Rawalpindi 2019
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Acceso en línea:https://doaj.org/article/41d036c01f504db884ffa7d3fefc9607
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spelling oai:doaj.org-article:41d036c01f504db884ffa7d3fefc96072021-11-12T07:12:10ZCOMPARISON OF EFFICACY OF TOPICAL CALCIPOTRIENE PLUS BETAMETHASONE WITH CALCIPOTRIENE ALONE IN LOCALIZED VITILIGO0030-96482411-8842https://doaj.org/article/41d036c01f504db884ffa7d3fefc96072019-04-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2760/2165https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To evaluate the efficacy of topical calcipotriene in comparison with topical calcipotriene plus betamethasone dipropionate in the treatment of localized vitiligo. Study Design: Randomized controlled trial. Place and Duration of Study: Study was carried out at department of Dermatology, Pak Emirates Military Hospital (PEMH) Rawalpindi and Combined Military Hospital (CMH) Lahore from June 2015 to December 2015. Material and Methods: Informed consent of the patients and approval of the hospital ethical committee were duly obtained. A total of 60 patients aged 15-40 years of either gender with localized vitiligo were included in the study. The disease was diagnosed on the basis of clinical features and wood’s lamp examination. Patients were randomly allocated into two groups (30 patients in each group) by lottery method. Group A patients, were given topical 0.005% calcipotriene ointment twice daily. Group B patients were given combination of topical 0.05% betamethasone dipropionate and 0.005% calcipotriene ointment twice daily. For evaluation of comparative efficacy, patients of both groups were examined every 4 weeks and at the end of 12th week of treatment. Repigmentation greater than 75% of the affected area in any case was documented as effective response. Results: Total 60 patients were inducted in the study, out of them treatment was effective in 35 (58.3%) patients whereas in 25 (41.7%) patients the treatment was ineffective. In-group A (calcipotriene), 13 (43.33%) patients had more than 75% repigmentation where as in group B (calcipotriene plus betamethasone), 22 (73.33%) patients had more than 75% repigmentation. Group B was numerically and statistically superior to group A in terms of effectiveness of drugs. Conclusion: Based on our study combination of topical betamethasone dipropionate with calcipotriene was found to be more effective than topical calcipotriene used alone in the treatment of localized vitiligo.Usman RiazZafar Iqbal ShaikhAnwar Ul IslamArmy Medical College Rawalpindiarticlebetamethasone dipropionatecalcipotrieneMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 2, Pp 383-390 (2019)
institution DOAJ
collection DOAJ
language EN
topic betamethasone dipropionate
calcipotriene
Medicine
R
Medicine (General)
R5-920
spellingShingle betamethasone dipropionate
calcipotriene
Medicine
R
Medicine (General)
R5-920
Usman Riaz
Zafar Iqbal Shaikh
Anwar Ul Islam
COMPARISON OF EFFICACY OF TOPICAL CALCIPOTRIENE PLUS BETAMETHASONE WITH CALCIPOTRIENE ALONE IN LOCALIZED VITILIGO
description Objective: To evaluate the efficacy of topical calcipotriene in comparison with topical calcipotriene plus betamethasone dipropionate in the treatment of localized vitiligo. Study Design: Randomized controlled trial. Place and Duration of Study: Study was carried out at department of Dermatology, Pak Emirates Military Hospital (PEMH) Rawalpindi and Combined Military Hospital (CMH) Lahore from June 2015 to December 2015. Material and Methods: Informed consent of the patients and approval of the hospital ethical committee were duly obtained. A total of 60 patients aged 15-40 years of either gender with localized vitiligo were included in the study. The disease was diagnosed on the basis of clinical features and wood’s lamp examination. Patients were randomly allocated into two groups (30 patients in each group) by lottery method. Group A patients, were given topical 0.005% calcipotriene ointment twice daily. Group B patients were given combination of topical 0.05% betamethasone dipropionate and 0.005% calcipotriene ointment twice daily. For evaluation of comparative efficacy, patients of both groups were examined every 4 weeks and at the end of 12th week of treatment. Repigmentation greater than 75% of the affected area in any case was documented as effective response. Results: Total 60 patients were inducted in the study, out of them treatment was effective in 35 (58.3%) patients whereas in 25 (41.7%) patients the treatment was ineffective. In-group A (calcipotriene), 13 (43.33%) patients had more than 75% repigmentation where as in group B (calcipotriene plus betamethasone), 22 (73.33%) patients had more than 75% repigmentation. Group B was numerically and statistically superior to group A in terms of effectiveness of drugs. Conclusion: Based on our study combination of topical betamethasone dipropionate with calcipotriene was found to be more effective than topical calcipotriene used alone in the treatment of localized vitiligo.
format article
author Usman Riaz
Zafar Iqbal Shaikh
Anwar Ul Islam
author_facet Usman Riaz
Zafar Iqbal Shaikh
Anwar Ul Islam
author_sort Usman Riaz
title COMPARISON OF EFFICACY OF TOPICAL CALCIPOTRIENE PLUS BETAMETHASONE WITH CALCIPOTRIENE ALONE IN LOCALIZED VITILIGO
title_short COMPARISON OF EFFICACY OF TOPICAL CALCIPOTRIENE PLUS BETAMETHASONE WITH CALCIPOTRIENE ALONE IN LOCALIZED VITILIGO
title_full COMPARISON OF EFFICACY OF TOPICAL CALCIPOTRIENE PLUS BETAMETHASONE WITH CALCIPOTRIENE ALONE IN LOCALIZED VITILIGO
title_fullStr COMPARISON OF EFFICACY OF TOPICAL CALCIPOTRIENE PLUS BETAMETHASONE WITH CALCIPOTRIENE ALONE IN LOCALIZED VITILIGO
title_full_unstemmed COMPARISON OF EFFICACY OF TOPICAL CALCIPOTRIENE PLUS BETAMETHASONE WITH CALCIPOTRIENE ALONE IN LOCALIZED VITILIGO
title_sort comparison of efficacy of topical calcipotriene plus betamethasone with calcipotriene alone in localized vitiligo
publisher Army Medical College Rawalpindi
publishDate 2019
url https://doaj.org/article/41d036c01f504db884ffa7d3fefc9607
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AT zafariqbalshaikh comparisonofefficacyoftopicalcalcipotrieneplusbetamethasonewithcalcipotrienealoneinlocalizedvitiligo
AT anwarulislam comparisonofefficacyoftopicalcalcipotrieneplusbetamethasonewithcalcipotrienealoneinlocalizedvitiligo
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