Full left ventricular coverage is essential for the accurate quantification of the area-at-risk by T1 and T2 mapping

Abstract T2-weighted cardiovascular magnetic resonance (CMR) using a 3-slice approach has been shown to accurately quantify the edema-based area-at-risk (AAR) in ST-segment elevation myocardial infarction (STEMI). We aimed to compare the performance of a 3-slice approach to full left ventricular (LV...

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Autores principales:	Heerajnarain Bulluck, Jennifer A. Bryant, Mei Xing Lim, Xiao Wei Tan, Manish Ramlall, Rohin Francis, Tushar Kotecha, Hector A. Cabrera-Fuentes, Daniel S. Knight, Marianna Fontana, James C. Moon, Derek J. Hausenloy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/41d6282a1299488eaae13fce87036d8e
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spelling	oai:doaj.org-article:41d6282a1299488eaae13fce87036d8e2021-12-02T16:06:04ZFull left ventricular coverage is essential for the accurate quantification of the area-at-risk by T1 and T2 mapping10.1038/s41598-017-05127-02045-2322https://doaj.org/article/41d6282a1299488eaae13fce87036d8e2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05127-0https://doaj.org/toc/2045-2322Abstract T2-weighted cardiovascular magnetic resonance (CMR) using a 3-slice approach has been shown to accurately quantify the edema-based area-at-risk (AAR) in ST-segment elevation myocardial infarction (STEMI). We aimed to compare the performance of a 3-slice approach to full left ventricular (LV) coverage for the AAR by T1 and T2 mapping and MI size. Forty-eight STEMI patients were prospectively recruited and underwent a CMR at 4 ± 2 days. There was no difference between the AARfull LV and AAR3-slices by T1 (P = 0.054) and T2-mapping (P = 0.092), with good correlations but small biases and wide limits of agreements (T1-mapping: N = 30, R2 = 0.85, bias = 1.7 ± 9.4% LV; T2-mapping: N = 48, R2 = 0.75, bias = 1.7 ± 12.9% LV). There was also no significant difference between MI size3-slices and MI sizefull LV (P = 0.93) with an excellent correlation between the two (R2 0.92) but a small bias of 0.5% and a wide limit of agreement of ±7.7%. Although MSI was similar between the 2 approaches, MSI3-slices performed poorly when MSI was <0.50. Furthermore, using AAR3-slices and MI sizefull LV resulted in ‘negative’ MSI in 7/48 patients. Full LV coverage T1 and T2 mapping are more accurate than a 3-slice approach for delineating the AAR, especially in those with MSI < 0.50 and we would advocate full LV coverage in future studies.Heerajnarain BulluckJennifer A. BryantMei Xing LimXiao Wei TanManish RamlallRohin FrancisTushar KotechaHector A. Cabrera-FuentesDaniel S. KnightMarianna FontanaJames C. MoonDerek J. HausenloyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Heerajnarain Bulluck Jennifer A. Bryant Mei Xing Lim Xiao Wei Tan Manish Ramlall Rohin Francis Tushar Kotecha Hector A. Cabrera-Fuentes Daniel S. Knight Marianna Fontana James C. Moon Derek J. Hausenloy Full left ventricular coverage is essential for the accurate quantification of the area-at-risk by T1 and T2 mapping
description	Abstract T2-weighted cardiovascular magnetic resonance (CMR) using a 3-slice approach has been shown to accurately quantify the edema-based area-at-risk (AAR) in ST-segment elevation myocardial infarction (STEMI). We aimed to compare the performance of a 3-slice approach to full left ventricular (LV) coverage for the AAR by T1 and T2 mapping and MI size. Forty-eight STEMI patients were prospectively recruited and underwent a CMR at 4 ± 2 days. There was no difference between the AARfull LV and AAR3-slices by T1 (P = 0.054) and T2-mapping (P = 0.092), with good correlations but small biases and wide limits of agreements (T1-mapping: N = 30, R2 = 0.85, bias = 1.7 ± 9.4% LV; T2-mapping: N = 48, R2 = 0.75, bias = 1.7 ± 12.9% LV). There was also no significant difference between MI size3-slices and MI sizefull LV (P = 0.93) with an excellent correlation between the two (R2 0.92) but a small bias of 0.5% and a wide limit of agreement of ±7.7%. Although MSI was similar between the 2 approaches, MSI3-slices performed poorly when MSI was <0.50. Furthermore, using AAR3-slices and MI sizefull LV resulted in ‘negative’ MSI in 7/48 patients. Full LV coverage T1 and T2 mapping are more accurate than a 3-slice approach for delineating the AAR, especially in those with MSI < 0.50 and we would advocate full LV coverage in future studies.
format	article
author	Heerajnarain Bulluck Jennifer A. Bryant Mei Xing Lim Xiao Wei Tan Manish Ramlall Rohin Francis Tushar Kotecha Hector A. Cabrera-Fuentes Daniel S. Knight Marianna Fontana James C. Moon Derek J. Hausenloy
author_facet	Heerajnarain Bulluck Jennifer A. Bryant Mei Xing Lim Xiao Wei Tan Manish Ramlall Rohin Francis Tushar Kotecha Hector A. Cabrera-Fuentes Daniel S. Knight Marianna Fontana James C. Moon Derek J. Hausenloy
author_sort	Heerajnarain Bulluck
title	Full left ventricular coverage is essential for the accurate quantification of the area-at-risk by T1 and T2 mapping
title_short	Full left ventricular coverage is essential for the accurate quantification of the area-at-risk by T1 and T2 mapping
title_full	Full left ventricular coverage is essential for the accurate quantification of the area-at-risk by T1 and T2 mapping
title_fullStr	Full left ventricular coverage is essential for the accurate quantification of the area-at-risk by T1 and T2 mapping
title_full_unstemmed	Full left ventricular coverage is essential for the accurate quantification of the area-at-risk by T1 and T2 mapping
title_sort	full left ventricular coverage is essential for the accurate quantification of the area-at-risk by t1 and t2 mapping
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/41d6282a1299488eaae13fce87036d8e
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Full left ventricular coverage is essential for the accurate quantification of the area-at-risk by T1 and T2 mapping

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