Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations

Mutations in the granulin gene are associated with frontotemporal lobe dementia (FTLD) and a lysosomal storage disease. The authors show that reduced progranulin levels leads to impaired neuronal uptake and lysosomal delivery of prosaposin, and that decreased prosaposin expression in mice leads to F...

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Autores principales:	Xiaolai Zhou, Lirong Sun, Oliver Bracko, Ji Whae Choi, Yan Jia, Alissa L. Nana, Owen Adam Brady, Jean C. Cruz Hernandez, Nozomi Nishimura, William W. Seeley, Fenghua Hu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/41d78f62c0c2475397bd2fa199e6bc5b
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spelling	oai:doaj.org-article:41d78f62c0c2475397bd2fa199e6bc5b2021-12-02T17:06:28ZImpaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations10.1038/ncomms152772041-1723https://doaj.org/article/41d78f62c0c2475397bd2fa199e6bc5b2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15277https://doaj.org/toc/2041-1723Mutations in the granulin gene are associated with frontotemporal lobe dementia (FTLD) and a lysosomal storage disease. The authors show that reduced progranulin levels leads to impaired neuronal uptake and lysosomal delivery of prosaposin, and that decreased prosaposin expression in mice leads to FTLD-like behaviour.Xiaolai ZhouLirong SunOliver BrackoJi Whae ChoiYan JiaAlissa L. NanaOwen Adam BradyJean C. Cruz HernandezNozomi NishimuraWilliam W. SeeleyFenghua HuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaolai Zhou Lirong Sun Oliver Bracko Ji Whae Choi Yan Jia Alissa L. Nana Owen Adam Brady Jean C. Cruz Hernandez Nozomi Nishimura William W. Seeley Fenghua Hu Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations
description	Mutations in the granulin gene are associated with frontotemporal lobe dementia (FTLD) and a lysosomal storage disease. The authors show that reduced progranulin levels leads to impaired neuronal uptake and lysosomal delivery of prosaposin, and that decreased prosaposin expression in mice leads to FTLD-like behaviour.
format	article
author	Xiaolai Zhou Lirong Sun Oliver Bracko Ji Whae Choi Yan Jia Alissa L. Nana Owen Adam Brady Jean C. Cruz Hernandez Nozomi Nishimura William W. Seeley Fenghua Hu
author_facet	Xiaolai Zhou Lirong Sun Oliver Bracko Ji Whae Choi Yan Jia Alissa L. Nana Owen Adam Brady Jean C. Cruz Hernandez Nozomi Nishimura William W. Seeley Fenghua Hu
author_sort	Xiaolai Zhou
title	Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations
title_short	Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations
title_full	Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations
title_fullStr	Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations
title_full_unstemmed	Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations
title_sort	impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/41d78f62c0c2475397bd2fa199e6bc5b
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Impaired prosaposin lysosomal trafficking in frontotemporal lobar degeneration due to progranulin mutations

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