OPSONIZING PROPERTIES OF A COMMERCIAL ANTISTAPHYLOCOCCAL IMMUNOGLOBULIN

Abstract. Antistaphylococcal immunoglobulins (ASIg) are widely used for treatment of staphylococcal infections. However, Russian literature sources still lack any evidence-based data justifying clinical efficiency of this preparation. Taking into account a key role of phagocytosis for a macro-organi...

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Autores principales:	S. V. Slobodchikova, K. V. Schmagel
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	antistaphylococcal immunoglobulin normal immunoglobulin s. aureus opsonization phagocytosis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/41d824edc69c4c1a81a45abca52f3e93
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spelling	oai:doaj.org-article:41d824edc69c4c1a81a45abca52f3e932021-11-18T08:03:40ZOPSONIZING PROPERTIES OF A COMMERCIAL ANTISTAPHYLOCOCCAL IMMUNOGLOBULIN1563-06252313-741X10.15789/1563-0625-2012-1-2-95-102https://doaj.org/article/41d824edc69c4c1a81a45abca52f3e932014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/302https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Antistaphylococcal immunoglobulins (ASIg) are widely used for treatment of staphylococcal infections. However, Russian literature sources still lack any evidence-based data justifying clinical efficiency of this preparation. Taking into account a key role of phagocytosis for a macro-organism resistance to staphylococci, and importance of microbial opsonization in this response, a trial of antistaphylococcal immunoglobulinmediated opsonizing activity was performed with S. aureus Wood 46 and S. aureus Cowan I strains. A normal human Ig preparation was used as a reference substance. Both preparations influenced oxygen-dependent bactericidal effects of phagocytes to a similar degree. Normal immunoglobulin proved to be more active than ASIg, with respect to neutrophil ingestion properties and bacterial aggregation. Hence, present results, along with relevant data from Russian and foreign literature put in question the ASIg expediency for medication of staphylococcal infections.S. V. SlobodchikovaK. V. SchmagelSPb RAACIarticleantistaphylococcal immunoglobulinnormal immunoglobulins. aureusopsonizationphagocytosisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 1-2, Pp 95-102 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	antistaphylococcal immunoglobulin normal immunoglobulin s. aureus opsonization phagocytosis Immunologic diseases. Allergy RC581-607
spellingShingle	antistaphylococcal immunoglobulin normal immunoglobulin s. aureus opsonization phagocytosis Immunologic diseases. Allergy RC581-607 S. V. Slobodchikova K. V. Schmagel OPSONIZING PROPERTIES OF A COMMERCIAL ANTISTAPHYLOCOCCAL IMMUNOGLOBULIN
description	Abstract. Antistaphylococcal immunoglobulins (ASIg) are widely used for treatment of staphylococcal infections. However, Russian literature sources still lack any evidence-based data justifying clinical efficiency of this preparation. Taking into account a key role of phagocytosis for a macro-organism resistance to staphylococci, and importance of microbial opsonization in this response, a trial of antistaphylococcal immunoglobulinmediated opsonizing activity was performed with S. aureus Wood 46 and S. aureus Cowan I strains. A normal human Ig preparation was used as a reference substance. Both preparations influenced oxygen-dependent bactericidal effects of phagocytes to a similar degree. Normal immunoglobulin proved to be more active than ASIg, with respect to neutrophil ingestion properties and bacterial aggregation. Hence, present results, along with relevant data from Russian and foreign literature put in question the ASIg expediency for medication of staphylococcal infections.
format	article
author	S. V. Slobodchikova K. V. Schmagel
author_facet	S. V. Slobodchikova K. V. Schmagel
author_sort	S. V. Slobodchikova
title	OPSONIZING PROPERTIES OF A COMMERCIAL ANTISTAPHYLOCOCCAL IMMUNOGLOBULIN
title_short	OPSONIZING PROPERTIES OF A COMMERCIAL ANTISTAPHYLOCOCCAL IMMUNOGLOBULIN
title_full	OPSONIZING PROPERTIES OF A COMMERCIAL ANTISTAPHYLOCOCCAL IMMUNOGLOBULIN
title_fullStr	OPSONIZING PROPERTIES OF A COMMERCIAL ANTISTAPHYLOCOCCAL IMMUNOGLOBULIN
title_full_unstemmed	OPSONIZING PROPERTIES OF A COMMERCIAL ANTISTAPHYLOCOCCAL IMMUNOGLOBULIN
title_sort	opsonizing properties of a commercial antistaphylococcal immunoglobulin
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/41d824edc69c4c1a81a45abca52f3e93
work_keys_str_mv	AT svslobodchikova opsonizingpropertiesofacommercialantistaphylococcalimmunoglobulin AT kvschmagel opsonizingpropertiesofacommercialantistaphylococcalimmunoglobulin
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OPSONIZING PROPERTIES OF A COMMERCIAL ANTISTAPHYLOCOCCAL IMMUNOGLOBULIN

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