TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis

Cytoplasmic stress granules (SG) are intracellular aggregates that suppress translation and sequester apoptosis regulatory factors. Here the authors show that reactive oxygen species oxidise the SG-nucleating protein TIA1, preventing SG formation and promoting apoptosis in the presence of additional...

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Autores principales:	Kyoko Arimoto-Matsuzaki, Haruo Saito, Mutsuhiro Takekawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/41d9396fe1f949b5ad42eb6adb89791d
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spelling	oai:doaj.org-article:41d9396fe1f949b5ad42eb6adb89791d2021-12-02T17:31:50ZTIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis10.1038/ncomms102522041-1723https://doaj.org/article/41d9396fe1f949b5ad42eb6adb89791d2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10252https://doaj.org/toc/2041-1723Cytoplasmic stress granules (SG) are intracellular aggregates that suppress translation and sequester apoptosis regulatory factors. Here the authors show that reactive oxygen species oxidise the SG-nucleating protein TIA1, preventing SG formation and promoting apoptosis in the presence of additional stress.Kyoko Arimoto-MatsuzakiHaruo SaitoMutsuhiro TakekawaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kyoko Arimoto-Matsuzaki Haruo Saito Mutsuhiro Takekawa TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis
description	Cytoplasmic stress granules (SG) are intracellular aggregates that suppress translation and sequester apoptosis regulatory factors. Here the authors show that reactive oxygen species oxidise the SG-nucleating protein TIA1, preventing SG formation and promoting apoptosis in the presence of additional stress.
format	article
author	Kyoko Arimoto-Matsuzaki Haruo Saito Mutsuhiro Takekawa
author_facet	Kyoko Arimoto-Matsuzaki Haruo Saito Mutsuhiro Takekawa
author_sort	Kyoko Arimoto-Matsuzaki
title	TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis
title_short	TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis
title_full	TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis
title_fullStr	TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis
title_full_unstemmed	TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis
title_sort	tia1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/41d9396fe1f949b5ad42eb6adb89791d
work_keys_str_mv	AT kyokoarimotomatsuzaki tia1oxidationinhibitsstressgranuleassemblyandsensitizescellstostressinducedapoptosis AT haruosaito tia1oxidationinhibitsstressgranuleassemblyandsensitizescellstostressinducedapoptosis AT mutsuhirotakekawa tia1oxidationinhibitsstressgranuleassemblyandsensitizescellstostressinducedapoptosis
_version_	1718380485594316800

TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis

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