Association Between IL-6 and Seizure Recurrence in Patients with the First Post-Ischemic Stroke Seizure

Qi Jia,1 Fan Jiang,2 Daliang Ma,1 Jun Li,1 Fan Wang,1 Zhiqiang Wang1 1Encephalopathy Center, The Third People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830000, People’s Republic of China; 2Neonatal Intensive Care Unit, The First People’s Hospital of Urumqi,...

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Autores principales:	Jia Q, Jiang F, Ma D, Li J, Wang F, Wang Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	post-ischemic stroke seizure seizure recurrence il-6 predictive value Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/41dc5e09e4d14363abc374893285ce9e
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spelling	oai:doaj.org-article:41dc5e09e4d14363abc374893285ce9e2021-12-02T10:19:45ZAssociation Between IL-6 and Seizure Recurrence in Patients with the First Post-Ischemic Stroke Seizure1178-2021https://doaj.org/article/41dc5e09e4d14363abc374893285ce9e2020-08-01T00:00:00Zhttps://www.dovepress.com/association-between-il-6-and-seizure-recurrence-in-patients-with-the-f-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Qi Jia,1 Fan Jiang,2 Daliang Ma,1 Jun Li,1 Fan Wang,1 Zhiqiang Wang1 1Encephalopathy Center, The Third People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830000, People’s Republic of China; 2Neonatal Intensive Care Unit, The First People’s Hospital of Urumqi, Urumqi 830000, People’s Republic of ChinaCorrespondence: Zhiqiang WangEncephalopathy Center, The Third People’s Hospital of Xinjiang Uygur Autonomous Region, No. 168, Nanchang Road, Urumqi 830000, People’s Republic of ChinaTel/ Fax +86-9917530284Email xjwjwzq@163.comPurpose: To study the association between IL-6 level and seizure recurrence in patients with the first post-ischemic stroke seizure and assess its predictive value for seizure recurrence.Patients and Methods: A total of 2976 consecutive ischemic stroke patients were retrospectively enrolled. Among them, 209 (7.02%) patients with the first post-ischemic stroke seizure were included in this analysis. The IL-6 mRNA expression level was evaluated through quantitative real-time PCR (qRT-PCR) and the 2−ΔΔCt method. Demographic data and clinical characteristics were collected. Univariate analysis was performed with independent-samples t-test, Mann–Whitney U-test, or chi-square test. Multivariate analysis was conducted using a backward stepwise logistic regression model for variables with P< 0.10 in univariate analysis. The predictive value was assessed using a receiver operating characteristic (ROC) curve.Results: Among the patients included, 105 (50.24%) had recurrence of seizures, and 104 (49.76%) had no recurrence. Multivariate analysis demonstrated that the IL-6 mRNA expression level was independently correlated with seizure recurrence in patients with the first post-ischemic stroke seizure after adjusting for age, NIHSS scores, time of seizure, seizure type, lesion size, location of the offending lesion to different hemispheric lobes, cortical involvement, gender, electroencephalography (EEG) findings, and hemorrhagic transformation. When the IL-6 mRNA expression level was used to predict seizure recurrence, the area under the ROC curve (AUC) was 0.763 (SE=0.033, 95% CI=0.698– 0.829). The diagnostic power was moderate.Conclusion: IL-6 was independently correlated with seizure recurrence in patients with the first post-ischemic stroke seizure and might be a potential biomarker for prediction of seizure recurrence.Keywords: post-ischemic stroke seizure, seizure recurrence, IL-6, predictive valueJia QJiang FMa DLi JWang FWang ZDove Medical Pressarticlepost-ischemic stroke seizureseizure recurrenceil-6predictive valueNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 1955-1963 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	post-ischemic stroke seizure seizure recurrence il-6 predictive value Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	post-ischemic stroke seizure seizure recurrence il-6 predictive value Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Jia Q Jiang F Ma D Li J Wang F Wang Z Association Between IL-6 and Seizure Recurrence in Patients with the First Post-Ischemic Stroke Seizure
description	Qi Jia,1 Fan Jiang,2 Daliang Ma,1 Jun Li,1 Fan Wang,1 Zhiqiang Wang1 1Encephalopathy Center, The Third People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830000, People’s Republic of China; 2Neonatal Intensive Care Unit, The First People’s Hospital of Urumqi, Urumqi 830000, People’s Republic of ChinaCorrespondence: Zhiqiang WangEncephalopathy Center, The Third People’s Hospital of Xinjiang Uygur Autonomous Region, No. 168, Nanchang Road, Urumqi 830000, People’s Republic of ChinaTel/ Fax +86-9917530284Email xjwjwzq@163.comPurpose: To study the association between IL-6 level and seizure recurrence in patients with the first post-ischemic stroke seizure and assess its predictive value for seizure recurrence.Patients and Methods: A total of 2976 consecutive ischemic stroke patients were retrospectively enrolled. Among them, 209 (7.02%) patients with the first post-ischemic stroke seizure were included in this analysis. The IL-6 mRNA expression level was evaluated through quantitative real-time PCR (qRT-PCR) and the 2−ΔΔCt method. Demographic data and clinical characteristics were collected. Univariate analysis was performed with independent-samples t-test, Mann–Whitney U-test, or chi-square test. Multivariate analysis was conducted using a backward stepwise logistic regression model for variables with P< 0.10 in univariate analysis. The predictive value was assessed using a receiver operating characteristic (ROC) curve.Results: Among the patients included, 105 (50.24%) had recurrence of seizures, and 104 (49.76%) had no recurrence. Multivariate analysis demonstrated that the IL-6 mRNA expression level was independently correlated with seizure recurrence in patients with the first post-ischemic stroke seizure after adjusting for age, NIHSS scores, time of seizure, seizure type, lesion size, location of the offending lesion to different hemispheric lobes, cortical involvement, gender, electroencephalography (EEG) findings, and hemorrhagic transformation. When the IL-6 mRNA expression level was used to predict seizure recurrence, the area under the ROC curve (AUC) was 0.763 (SE=0.033, 95% CI=0.698– 0.829). The diagnostic power was moderate.Conclusion: IL-6 was independently correlated with seizure recurrence in patients with the first post-ischemic stroke seizure and might be a potential biomarker for prediction of seizure recurrence.Keywords: post-ischemic stroke seizure, seizure recurrence, IL-6, predictive value
format	article
author	Jia Q Jiang F Ma D Li J Wang F Wang Z
author_facet	Jia Q Jiang F Ma D Li J Wang F Wang Z
author_sort	Jia Q
title	Association Between IL-6 and Seizure Recurrence in Patients with the First Post-Ischemic Stroke Seizure
title_short	Association Between IL-6 and Seizure Recurrence in Patients with the First Post-Ischemic Stroke Seizure
title_full	Association Between IL-6 and Seizure Recurrence in Patients with the First Post-Ischemic Stroke Seizure
title_fullStr	Association Between IL-6 and Seizure Recurrence in Patients with the First Post-Ischemic Stroke Seizure
title_full_unstemmed	Association Between IL-6 and Seizure Recurrence in Patients with the First Post-Ischemic Stroke Seizure
title_sort	association between il-6 and seizure recurrence in patients with the first post-ischemic stroke seizure
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/41dc5e09e4d14363abc374893285ce9e
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Association Between IL-6 and Seizure Recurrence in Patients with the First Post-Ischemic Stroke Seizure

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