Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma

Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma

Osteosarcomas are difficult to treat and have a limited response to immunotherapy. Here, the authors analyse osteosarcomas at the single-cell level, and identify both the transdifferentiation of malignant cells and an array of immune cells that could have implications for metastasis and immunotherap...

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Autores principales: Yan Zhou, Dong Yang, Qingcheng Yang, Xiaobin Lv, Wentao Huang, Zhenhua Zhou, Yaling Wang, Zhichang Zhang, Ting Yuan, Xiaomin Ding, Lina Tang, Jianjun Zhang, Junyi Yin, Yujing Huang, Wenxi Yu, Yonggang Wang, Chenliang Zhou, Yang Su, Aina He, Yuanjue Sun, Zan Shen, Binzhi Qian, Wei Meng, Jia Fei, Yang Yao, Xinghua Pan, Peizhan Chen, Haiyan Hu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/41de5804a75d4d98bfa174ff84c5c9b5
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spelling oai:doaj.org-article:41de5804a75d4d98bfa174ff84c5c9b52021-12-02T10:47:51ZSingle-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma10.1038/s41467-020-20059-62041-1723https://doaj.org/article/41de5804a75d4d98bfa174ff84c5c9b52020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20059-6https://doaj.org/toc/2041-1723Osteosarcomas are difficult to treat and have a limited response to immunotherapy. Here, the authors analyse osteosarcomas at the single-cell level, and identify both the transdifferentiation of malignant cells and an array of immune cells that could have implications for metastasis and immunotherapy.Yan ZhouDong YangQingcheng YangXiaobin LvWentao HuangZhenhua ZhouYaling WangZhichang ZhangTing YuanXiaomin DingLina TangJianjun ZhangJunyi YinYujing HuangWenxi YuYonggang WangChenliang ZhouYang SuAina HeYuanjue SunZan ShenBinzhi QianWei MengJia FeiYang YaoXinghua PanPeizhan ChenHaiyan HuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yan Zhou
Dong Yang
Qingcheng Yang
Xiaobin Lv
Wentao Huang
Zhenhua Zhou
Yaling Wang
Zhichang Zhang
Ting Yuan
Xiaomin Ding
Lina Tang
Jianjun Zhang
Junyi Yin
Yujing Huang
Wenxi Yu
Yonggang Wang
Chenliang Zhou
Yang Su
Aina He
Yuanjue Sun
Zan Shen
Binzhi Qian
Wei Meng
Jia Fei
Yang Yao
Xinghua Pan
Peizhan Chen
Haiyan Hu
Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma
description Osteosarcomas are difficult to treat and have a limited response to immunotherapy. Here, the authors analyse osteosarcomas at the single-cell level, and identify both the transdifferentiation of malignant cells and an array of immune cells that could have implications for metastasis and immunotherapy.
format article
author Yan Zhou
Dong Yang
Qingcheng Yang
Xiaobin Lv
Wentao Huang
Zhenhua Zhou
Yaling Wang
Zhichang Zhang
Ting Yuan
Xiaomin Ding
Lina Tang
Jianjun Zhang
Junyi Yin
Yujing Huang
Wenxi Yu
Yonggang Wang
Chenliang Zhou
Yang Su
Aina He
Yuanjue Sun
Zan Shen
Binzhi Qian
Wei Meng
Jia Fei
Yang Yao
Xinghua Pan
Peizhan Chen
Haiyan Hu
author_facet Yan Zhou
Dong Yang
Qingcheng Yang
Xiaobin Lv
Wentao Huang
Zhenhua Zhou
Yaling Wang
Zhichang Zhang
Ting Yuan
Xiaomin Ding
Lina Tang
Jianjun Zhang
Junyi Yin
Yujing Huang
Wenxi Yu
Yonggang Wang
Chenliang Zhou
Yang Su
Aina He
Yuanjue Sun
Zan Shen
Binzhi Qian
Wei Meng
Jia Fei
Yang Yao
Xinghua Pan
Peizhan Chen
Haiyan Hu
author_sort Yan Zhou
title Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma
title_short Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma
title_full Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma
title_fullStr Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma
title_full_unstemmed Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma
title_sort single-cell rna landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/41de5804a75d4d98bfa174ff84c5c9b5
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