Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma

Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma

Osteosarcomas are difficult to treat and have a limited response to immunotherapy. Here, the authors analyse osteosarcomas at the single-cell level, and identify both the transdifferentiation of malignant cells and an array of immune cells that could have implications for metastasis and immunotherap...

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Autores principales: Yan Zhou, Dong Yang, Qingcheng Yang, Xiaobin Lv, Wentao Huang, Zhenhua Zhou, Yaling Wang, Zhichang Zhang, Ting Yuan, Xiaomin Ding, Lina Tang, Jianjun Zhang, Junyi Yin, Yujing Huang, Wenxi Yu, Yonggang Wang, Chenliang Zhou, Yang Su, Aina He, Yuanjue Sun, Zan Shen, Binzhi Qian, Wei Meng, Jia Fei, Yang Yao, Xinghua Pan, Peizhan Chen, Haiyan Hu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/41de5804a75d4d98bfa174ff84c5c9b5
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